Role of centers with different patient volumes in the management of rhabdomyosarcoma. An analysis by the Italian Pediatric Soft Tissue Sarcoma Committee

Procedure The survival of children with rhabdomyosarcoma (RMS) has gradually improved as a result of the adoption of multidisciplinary treatments. Dedicated skills and facilities are indispensable and more readily available at reference centers. In this study, we examined the role of centers’ experi...

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Veröffentlicht in:Pediatric blood & cancer 2021-12, Vol.68 (12), p.e29234-n/a, Article 29234
Hauptverfasser: Bisogno, Gianni, Congiu, Giovanna, Affinita, Maria Carmen, Milano, Giuseppe Maria, Zanetti, Ilaria, Coppadoro, Beatrice, Manzitti, Carla, Basso, Eleonora, Tamburini, Angela, Melchionda, Fraia, Cellini, Monica, Pericoli, Roberta, D'Angelo, Paolo, Cataldo, Andrea Di, De Leonardis, Francesco, Rabusin, Marco, De Corti, Federica, Zin, Angelica, Alaggio, Rita, Scarzello, Giovanni, Ferrari, Andrea
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container_issue 12
container_start_page e29234
container_title Pediatric blood & cancer
container_volume 68
creator Bisogno, Gianni
Congiu, Giovanna
Affinita, Maria Carmen
Milano, Giuseppe Maria
Zanetti, Ilaria
Coppadoro, Beatrice
Manzitti, Carla
Basso, Eleonora
Tamburini, Angela
Melchionda, Fraia
Cellini, Monica
Pericoli, Roberta
D'Angelo, Paolo
Cataldo, Andrea Di
De Leonardis, Francesco
Rabusin, Marco
De Corti, Federica
Zin, Angelica
Alaggio, Rita
Scarzello, Giovanni
Ferrari, Andrea
description Procedure The survival of children with rhabdomyosarcoma (RMS) has gradually improved as a result of the adoption of multidisciplinary treatments. Dedicated skills and facilities are indispensable and more readily available at reference centers. In this study, we examined the role of centers’ experience (based on the number of patients treated) in their management of patients with RMS. Methods We analyzed 342 patients with localized RMS enrolled in the European RMS 2005 protocol from October 2005 to December 2016 at 31 Italian centers that are part of the Soft Tissue Sarcoma Committee (STSC). We grouped the centers by the number of patients each one enrolled (Group 1: >40; Group 2: 10; and Group 3:
doi_str_mv 10.1002/pbc.29234
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An analysis by the Italian Pediatric Soft Tissue Sarcoma Committee</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2021&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><creator>Bisogno, Gianni ; Congiu, Giovanna ; Affinita, Maria Carmen ; Milano, Giuseppe Maria ; Zanetti, Ilaria ; Coppadoro, Beatrice ; Manzitti, Carla ; Basso, Eleonora ; Tamburini, Angela ; Melchionda, Fraia ; Cellini, Monica ; Pericoli, Roberta ; D'Angelo, Paolo ; Cataldo, Andrea Di ; De Leonardis, Francesco ; Rabusin, Marco ; De Corti, Federica ; Zin, Angelica ; Alaggio, Rita ; Scarzello, Giovanni ; Ferrari, Andrea</creator><creatorcontrib>Bisogno, Gianni ; Congiu, Giovanna ; Affinita, Maria Carmen ; Milano, Giuseppe Maria ; Zanetti, Ilaria ; Coppadoro, Beatrice ; Manzitti, Carla ; Basso, Eleonora ; Tamburini, Angela ; Melchionda, Fraia ; Cellini, Monica ; Pericoli, Roberta ; D'Angelo, Paolo ; Cataldo, Andrea Di ; De Leonardis, Francesco ; Rabusin, Marco ; De Corti, Federica ; Zin, Angelica ; Alaggio, Rita ; Scarzello, Giovanni ; Ferrari, Andrea</creatorcontrib><description>Procedure The survival of children with rhabdomyosarcoma (RMS) has gradually improved as a result of the adoption of multidisciplinary treatments. Dedicated skills and facilities are indispensable and more readily available at reference centers. In this study, we examined the role of centers’ experience (based on the number of patients treated) in their management of patients with RMS. Methods We analyzed 342 patients with localized RMS enrolled in the European RMS 2005 protocol from October 2005 to December 2016 at 31 Italian centers that are part of the Soft Tissue Sarcoma Committee (STSC). We grouped the centers by the number of patients each one enrolled (Group 1: &gt;40; Group 2: &lt;40 and &gt;10; and Group 3: &lt;10), and compared a number of indicators to assess the appropriateness of patients’ diagnostic workup and treatment and their survival. Results Overall, 74.6% of patients were treated at 10 centers, and only three of them classifiable as high‐volume centers. Only minor differences emerged between the three patient groups in terms of diagnostic investigations and treatment modalities. Survival was similar in the three groups. Approximately, one in four children treated at the centers in Groups 2 and 3 traveled to another center for surgery or radiotherapy. Conclusion Patients treated at STSC centers with different amounts of experience had similar results in terms of survival. This is attributable to all centers in the network adhering to protocol recommendations and receiving the STSC's support on diagnostics and multidisciplinary treatments for RMS.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.29234</identifier><identifier>PMID: 34260145</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>centers’ experience ; Child ; Children ; Hematology ; Humans ; Italy ; Life Sciences &amp; Biomedicine ; multidisciplinary treatment ; network ; Oncology ; Patients ; Pediatrics ; Radiation therapy ; Rhabdomyosarcoma ; Rhabdomyosarcoma - surgery ; Rhabdomyosarcoma, Embryonal ; Sarcoma ; Science &amp; Technology ; Soft Tissue Neoplasms - therapy ; Soft tissue sarcoma ; Survival</subject><ispartof>Pediatric blood &amp; cancer, 2021-12, Vol.68 (12), p.e29234-n/a, Article 29234</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>0</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000673281900001</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c3134-484e2e26b02c6c0781231d46eac9f24f013ed80d3618feb869641276e8af0c53</cites><orcidid>0000-0002-0250-6043 ; 0000-0001-5801-7225 ; 0000-0002-4509-3066 ; 0000-0003-4462-5523 ; 0000-0002-6339-8576 ; 0000-0002-4724-0517 ; 0000-0003-1680-0240</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.29234$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.29234$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,39265,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34260145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bisogno, Gianni</creatorcontrib><creatorcontrib>Congiu, Giovanna</creatorcontrib><creatorcontrib>Affinita, Maria Carmen</creatorcontrib><creatorcontrib>Milano, Giuseppe Maria</creatorcontrib><creatorcontrib>Zanetti, Ilaria</creatorcontrib><creatorcontrib>Coppadoro, Beatrice</creatorcontrib><creatorcontrib>Manzitti, Carla</creatorcontrib><creatorcontrib>Basso, Eleonora</creatorcontrib><creatorcontrib>Tamburini, Angela</creatorcontrib><creatorcontrib>Melchionda, Fraia</creatorcontrib><creatorcontrib>Cellini, Monica</creatorcontrib><creatorcontrib>Pericoli, Roberta</creatorcontrib><creatorcontrib>D'Angelo, Paolo</creatorcontrib><creatorcontrib>Cataldo, Andrea Di</creatorcontrib><creatorcontrib>De Leonardis, Francesco</creatorcontrib><creatorcontrib>Rabusin, Marco</creatorcontrib><creatorcontrib>De Corti, Federica</creatorcontrib><creatorcontrib>Zin, Angelica</creatorcontrib><creatorcontrib>Alaggio, Rita</creatorcontrib><creatorcontrib>Scarzello, Giovanni</creatorcontrib><creatorcontrib>Ferrari, Andrea</creatorcontrib><title>Role of centers with different patient volumes in the management of rhabdomyosarcoma. An analysis by the Italian Pediatric Soft Tissue Sarcoma Committee</title><title>Pediatric blood &amp; cancer</title><addtitle>PEDIATR BLOOD CANCER</addtitle><addtitle>Pediatr Blood Cancer</addtitle><description>Procedure The survival of children with rhabdomyosarcoma (RMS) has gradually improved as a result of the adoption of multidisciplinary treatments. Dedicated skills and facilities are indispensable and more readily available at reference centers. In this study, we examined the role of centers’ experience (based on the number of patients treated) in their management of patients with RMS. Methods We analyzed 342 patients with localized RMS enrolled in the European RMS 2005 protocol from October 2005 to December 2016 at 31 Italian centers that are part of the Soft Tissue Sarcoma Committee (STSC). We grouped the centers by the number of patients each one enrolled (Group 1: &gt;40; Group 2: &lt;40 and &gt;10; and Group 3: &lt;10), and compared a number of indicators to assess the appropriateness of patients’ diagnostic workup and treatment and their survival. Results Overall, 74.6% of patients were treated at 10 centers, and only three of them classifiable as high‐volume centers. Only minor differences emerged between the three patient groups in terms of diagnostic investigations and treatment modalities. Survival was similar in the three groups. Approximately, one in four children treated at the centers in Groups 2 and 3 traveled to another center for surgery or radiotherapy. Conclusion Patients treated at STSC centers with different amounts of experience had similar results in terms of survival. This is attributable to all centers in the network adhering to protocol recommendations and receiving the STSC's support on diagnostics and multidisciplinary treatments for RMS.</description><subject>centers’ experience</subject><subject>Child</subject><subject>Children</subject><subject>Hematology</subject><subject>Humans</subject><subject>Italy</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>multidisciplinary treatment</subject><subject>network</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Radiation therapy</subject><subject>Rhabdomyosarcoma</subject><subject>Rhabdomyosarcoma - surgery</subject><subject>Rhabdomyosarcoma, Embryonal</subject><subject>Sarcoma</subject><subject>Science &amp; Technology</subject><subject>Soft Tissue Neoplasms - therapy</subject><subject>Soft tissue sarcoma</subject><subject>Survival</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqN0UFrFDEYBuAgiq3Vg39AAl4sstskk8lkjnWoWihY7N6HTOaLmzKZrEmmZf6JP9dsZ92DIHjKR_K8IeFF6C0la0oIu9h1es1qVvBn6JSWvFyVhFbPjzOpT9CrGO8zFaSUL9FJwfNEeXmKfn33A2BvsIYxQYj40aYt7q0xEPIO3qlk9-uDHyYHEdsRpy1gp0b1A9z-JGfDVnW9d7OPKmjv1BpfjjiLYY424m5-ilwnNVg14lvorUrBanznTcIbG-ME-G5J4sY7Z1MCeI1eGDVEeHNYz9Dm89Wm-bq6-fblurm8WemCFnzFJQcGTHSEaaFJJSkraM8FKF0bxg2hBfSS9IWg0kAnRS04ZZUAqQzRZXGGPizX7oL_OUFMrbNRwzCoEfwUW1aWtKxqQWSm7_-i934K-Zd7JTmvJKurrM4XpYOPMYBpd8E6FeaWknbfVpvbap_ayvbd4capc9Af5Z96MpALeITOm6hzFRqOjBAiqoJJWueJ0MamXJYfGz-NKUc__n8064uDtgPM_35ye_upWd7-Gyarv-A</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Bisogno, Gianni</creator><creator>Congiu, Giovanna</creator><creator>Affinita, Maria Carmen</creator><creator>Milano, Giuseppe Maria</creator><creator>Zanetti, Ilaria</creator><creator>Coppadoro, Beatrice</creator><creator>Manzitti, Carla</creator><creator>Basso, Eleonora</creator><creator>Tamburini, Angela</creator><creator>Melchionda, Fraia</creator><creator>Cellini, Monica</creator><creator>Pericoli, Roberta</creator><creator>D'Angelo, Paolo</creator><creator>Cataldo, Andrea Di</creator><creator>De Leonardis, Francesco</creator><creator>Rabusin, Marco</creator><creator>De Corti, Federica</creator><creator>Zin, Angelica</creator><creator>Alaggio, Rita</creator><creator>Scarzello, Giovanni</creator><creator>Ferrari, Andrea</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0250-6043</orcidid><orcidid>https://orcid.org/0000-0001-5801-7225</orcidid><orcidid>https://orcid.org/0000-0002-4509-3066</orcidid><orcidid>https://orcid.org/0000-0003-4462-5523</orcidid><orcidid>https://orcid.org/0000-0002-6339-8576</orcidid><orcidid>https://orcid.org/0000-0002-4724-0517</orcidid><orcidid>https://orcid.org/0000-0003-1680-0240</orcidid></search><sort><creationdate>202112</creationdate><title>Role of centers with different patient volumes in the management of rhabdomyosarcoma. An analysis by the Italian Pediatric Soft Tissue Sarcoma Committee</title><author>Bisogno, Gianni ; Congiu, Giovanna ; Affinita, Maria Carmen ; Milano, Giuseppe Maria ; Zanetti, Ilaria ; Coppadoro, Beatrice ; Manzitti, Carla ; Basso, Eleonora ; Tamburini, Angela ; Melchionda, Fraia ; Cellini, Monica ; Pericoli, Roberta ; D'Angelo, Paolo ; Cataldo, Andrea Di ; De Leonardis, Francesco ; Rabusin, Marco ; De Corti, Federica ; Zin, Angelica ; Alaggio, Rita ; Scarzello, Giovanni ; Ferrari, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3134-484e2e26b02c6c0781231d46eac9f24f013ed80d3618feb869641276e8af0c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>centers’ experience</topic><topic>Child</topic><topic>Children</topic><topic>Hematology</topic><topic>Humans</topic><topic>Italy</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>multidisciplinary treatment</topic><topic>network</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Radiation therapy</topic><topic>Rhabdomyosarcoma</topic><topic>Rhabdomyosarcoma - surgery</topic><topic>Rhabdomyosarcoma, Embryonal</topic><topic>Sarcoma</topic><topic>Science &amp; Technology</topic><topic>Soft Tissue Neoplasms - therapy</topic><topic>Soft tissue sarcoma</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bisogno, Gianni</creatorcontrib><creatorcontrib>Congiu, Giovanna</creatorcontrib><creatorcontrib>Affinita, Maria Carmen</creatorcontrib><creatorcontrib>Milano, Giuseppe Maria</creatorcontrib><creatorcontrib>Zanetti, Ilaria</creatorcontrib><creatorcontrib>Coppadoro, Beatrice</creatorcontrib><creatorcontrib>Manzitti, Carla</creatorcontrib><creatorcontrib>Basso, Eleonora</creatorcontrib><creatorcontrib>Tamburini, Angela</creatorcontrib><creatorcontrib>Melchionda, Fraia</creatorcontrib><creatorcontrib>Cellini, Monica</creatorcontrib><creatorcontrib>Pericoli, Roberta</creatorcontrib><creatorcontrib>D'Angelo, Paolo</creatorcontrib><creatorcontrib>Cataldo, Andrea Di</creatorcontrib><creatorcontrib>De Leonardis, Francesco</creatorcontrib><creatorcontrib>Rabusin, Marco</creatorcontrib><creatorcontrib>De Corti, Federica</creatorcontrib><creatorcontrib>Zin, Angelica</creatorcontrib><creatorcontrib>Alaggio, Rita</creatorcontrib><creatorcontrib>Scarzello, Giovanni</creatorcontrib><creatorcontrib>Ferrari, Andrea</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood &amp; cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bisogno, Gianni</au><au>Congiu, Giovanna</au><au>Affinita, Maria Carmen</au><au>Milano, Giuseppe Maria</au><au>Zanetti, Ilaria</au><au>Coppadoro, Beatrice</au><au>Manzitti, Carla</au><au>Basso, Eleonora</au><au>Tamburini, Angela</au><au>Melchionda, Fraia</au><au>Cellini, Monica</au><au>Pericoli, Roberta</au><au>D'Angelo, Paolo</au><au>Cataldo, Andrea Di</au><au>De Leonardis, Francesco</au><au>Rabusin, Marco</au><au>De Corti, Federica</au><au>Zin, Angelica</au><au>Alaggio, Rita</au><au>Scarzello, Giovanni</au><au>Ferrari, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of centers with different patient volumes in the management of rhabdomyosarcoma. An analysis by the Italian Pediatric Soft Tissue Sarcoma Committee</atitle><jtitle>Pediatric blood &amp; cancer</jtitle><stitle>PEDIATR BLOOD CANCER</stitle><addtitle>Pediatr Blood Cancer</addtitle><date>2021-12</date><risdate>2021</risdate><volume>68</volume><issue>12</issue><spage>e29234</spage><epage>n/a</epage><pages>e29234-n/a</pages><artnum>29234</artnum><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Procedure The survival of children with rhabdomyosarcoma (RMS) has gradually improved as a result of the adoption of multidisciplinary treatments. Dedicated skills and facilities are indispensable and more readily available at reference centers. In this study, we examined the role of centers’ experience (based on the number of patients treated) in their management of patients with RMS. Methods We analyzed 342 patients with localized RMS enrolled in the European RMS 2005 protocol from October 2005 to December 2016 at 31 Italian centers that are part of the Soft Tissue Sarcoma Committee (STSC). We grouped the centers by the number of patients each one enrolled (Group 1: &gt;40; Group 2: &lt;40 and &gt;10; and Group 3: &lt;10), and compared a number of indicators to assess the appropriateness of patients’ diagnostic workup and treatment and their survival. Results Overall, 74.6% of patients were treated at 10 centers, and only three of them classifiable as high‐volume centers. Only minor differences emerged between the three patient groups in terms of diagnostic investigations and treatment modalities. Survival was similar in the three groups. Approximately, one in four children treated at the centers in Groups 2 and 3 traveled to another center for surgery or radiotherapy. Conclusion Patients treated at STSC centers with different amounts of experience had similar results in terms of survival. This is attributable to all centers in the network adhering to protocol recommendations and receiving the STSC's support on diagnostics and multidisciplinary treatments for RMS.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>34260145</pmid><doi>10.1002/pbc.29234</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0250-6043</orcidid><orcidid>https://orcid.org/0000-0001-5801-7225</orcidid><orcidid>https://orcid.org/0000-0002-4509-3066</orcidid><orcidid>https://orcid.org/0000-0003-4462-5523</orcidid><orcidid>https://orcid.org/0000-0002-6339-8576</orcidid><orcidid>https://orcid.org/0000-0002-4724-0517</orcidid><orcidid>https://orcid.org/0000-0003-1680-0240</orcidid></addata></record>
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subjects centers’ experience
Child
Children
Hematology
Humans
Italy
Life Sciences & Biomedicine
multidisciplinary treatment
network
Oncology
Patients
Pediatrics
Radiation therapy
Rhabdomyosarcoma
Rhabdomyosarcoma - surgery
Rhabdomyosarcoma, Embryonal
Sarcoma
Science & Technology
Soft Tissue Neoplasms - therapy
Soft tissue sarcoma
Survival
title Role of centers with different patient volumes in the management of rhabdomyosarcoma. An analysis by the Italian Pediatric Soft Tissue Sarcoma Committee
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