EFFECTS OF AMENTOFLAVONE ON HIPPOCAMPAL NEURON DAMAGE AND OXIDATIVE STRESS IN DRUG-INDUCED EPILEPTIC RATS

Objective: To analyze the effects of amentoflavone (AF) on neuronal damage and oxidative stress in epileptic rats induced by drugs. Methods: Fifteen disease-free SD rats were randomly divided into an AF intervention group, a model group, and a blank control group, with five rats in each group. The AF intervention group was given an intraperitoneal injection of 25 mg/kg AF for five consecutive days, while the model group and blank control group were given intraperitoneal injections of the same amount of normal saline. On the fifth day, the AF intervention group and the model group were intraperitoneally injected with lithium chloride 127 mg/kg. After 18 hours, 30 mg/kg pilocarpine was injected intraperitoneally to induce seizures. A Morris water maze test of rat behavioral responses, immunohistochemical methods, and the ELISA method was used to detect the positive expression and activity of NF-kappa B p65 and to compare oxidative stress indicators (MAD, SOD, GSH) of rats in each group. Results: The escape latency time of the model group was significantly longer than that of the blank control group (P