Computational Drug Repurposing for Alzheimer's Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies

Background: Traditional therapeutics targeting Alzheimer's disease (AD)-related subpathologies have so far proved ineffective. Drug repurposing, a more effective strategy that aims to find new indications for existing drugs against other diseases, offers benefits in AD drug development. In this...

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Veröffentlicht in:	Frontiers in pharmacology 2021-06, Vol.12, Article 617537
Hauptverfasser:	Xu, Yun, Kong, Jiming, Hu, Pingzhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease computational approach drug repurposing gene signatures genome-wide association study Life Sciences & Biomedicine pathway enrichment Pharmacology Pharmacology & Pharmacy Science & Technology
Online-Zugang:	Volltext
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