Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice

BACKGROUND: Exposure to secondhand smoke (SHS) is a risk factor for developing sporadic forms of sporadic dementia. A human tau (htau) mouse model is available that exhibits age-dependent tau dysregulation, neurofibrillary tangles, neuronal loss, neuroinflammation, and oxidative stress starting at a...

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Veröffentlicht in:	Environmental health perspectives 2021-05, Vol.129 (5), p.57009, Article 057009
Hauptverfasser:	Raber, Jacob, Perez, Ruby, Torres, Eileen Ruth S., Krenik, Destine, Boutros, Sydney, Patel, Esha, Chlebowski, Anna C., Torres, Estefania Ramos, Perveen, Zakia, Penn, Arthur, Paulsen, Daniel B., Bartlett, Michael G., Jia, Enze, Holden, Sarah, Hall, Reed, Morre, Jeffrey, Wong, Carmen, Ho, Emily, Choi, Jaewoo, Stevens, Jan Frederik, Noel, Alexandra, Bobe, Gerd, Kisby, Glen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Age Alzheimer's disease Animal cognition Ascorbic acid Brain Brain research Chromatography Cognition disorders Cognitive ability Dementia Dementia disorders Development and progression Disease Environmental Sciences Environmental Sciences & Ecology Exposure Flavin Flavin-adenine dinucleotide Gene expression Genotypes Health aspects Hippocampus Hippocampus (Brain) Hsp90 protein Inflammation Injuries Laboratory animals Life Sciences & Biomedicine Males Mass spectrometry Metabolic pathways Metabolism Metabolites Neurofibrillary tangles Oxidative stress Palmitoleic acid Passive smoking Pathology Plasma Psychological aspects Public, Environmental & Occupational Health Risk analysis Risk factors Science & Technology Scientific imaging Spontaneous alternation Tau protein Tobacco smoke Toxicology
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