Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling
Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case...
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| Veröffentlicht in: | Pediatric and developmental pathology 2021-11, Vol.24 (6), p.581-584, Article 10935266211025122 |
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| creator | Roberts, James Cheng, Jeanette D Moore, Elizabeth Ransom, Carla Ma, Minhui Rogers, Beverly B |
| description | Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition. |
| doi_str_mv | 10.1177/10935266211025122 |
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Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.</description><identifier>ISSN: 1093-5266</identifier><identifier>EISSN: 1615-5742</identifier><identifier>DOI: 10.1177/10935266211025122</identifier><identifier>PMID: 34176361</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; COVID-19 - transmission ; COVID-19 - virology ; Female ; Fibrin - metabolism ; Histiocytosis - pathology ; Histiocytosis - virology ; Humans ; Immunohistochemistry ; Infant, Newborn ; Life Sciences & Biomedicine ; Pathology ; Pediatrics ; Placenta - pathology ; Placenta - virology ; Pregnancy ; Pregnancy Complications, Infectious - pathology ; Pregnancy Complications, Infectious - virology ; SARS-CoV-2 - physiology ; Science & Technology ; Trophoblasts - pathology ; Trophoblasts - virology</subject><ispartof>Pediatric and developmental pathology, 2021-11, Vol.24 (6), p.581-584, Article 10935266211025122</ispartof><rights>2021, Society for Pediatric Pathology All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>5</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000670636900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c383t-b0202ef6bb927f99d49b0754a59cc0e080d6d401c19b7d9bb38d0286c34637403</citedby><cites>FETCH-LOGICAL-c383t-b0202ef6bb927f99d49b0754a59cc0e080d6d401c19b7d9bb38d0286c34637403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10935266211025122$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10935266211025122$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,782,786,21826,27931,27932,39265,43628,43629</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34176361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, James</creatorcontrib><creatorcontrib>Cheng, Jeanette D</creatorcontrib><creatorcontrib>Moore, Elizabeth</creatorcontrib><creatorcontrib>Ransom, Carla</creatorcontrib><creatorcontrib>Ma, Minhui</creatorcontrib><creatorcontrib>Rogers, Beverly B</creatorcontrib><title>Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling</title><title>Pediatric and developmental pathology</title><addtitle>PEDIATR DEVEL PATHOL</addtitle><addtitle>Pediatr Dev Pathol</addtitle><description>Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.</description><subject>Adult</subject><subject>COVID-19 - transmission</subject><subject>COVID-19 - virology</subject><subject>Female</subject><subject>Fibrin - metabolism</subject><subject>Histiocytosis - pathology</subject><subject>Histiocytosis - virology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infant, Newborn</subject><subject>Life Sciences & Biomedicine</subject><subject>Pathology</subject><subject>Pediatrics</subject><subject>Placenta - pathology</subject><subject>Placenta - virology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - pathology</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>SARS-CoV-2 - physiology</subject><subject>Science & Technology</subject><subject>Trophoblasts - pathology</subject><subject>Trophoblasts - virology</subject><issn>1093-5266</issn><issn>1615-5742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhiMEoqXwAFyQj0hVythJnJjbKurSlaqyainXyHYmravEXmynpU_FK9ar7faChDh55P_7Z0bzZ9lHCieU1vUXCqKoGOeMUmAVZexVdkg5rfKqLtnrVCc93wIH2bsQ7gCSicPb7KAoac0LTg-zP6e_I9pg7pGs0Zt7M45uDmRplDeWSNuTlY3o9_9nJkTj9GN0wQSyJcjV4vIqb93PnCV0QB2xJ-tRarRRkqV3U-pCrq3Zaxf4oJy3X8mCtDIgucSN8zF59Tj3xt6Q1TTN1t2mSU7f4mS0HMnau8GMSX2fvRnkGPDD83uUXS9Pf7Rn-fn3b6t2cZ7roiliroABw4ErJVg9CNGXQkFdlbISWgNCAz3vS6CaClX3Qqmi6YE1XBclL-oSiqPs867vxrtfM4bYTSZoHEdpMR2iY1VZiaYG3iSU7lDtXQgeh27jzST9Y0eh2-bU_ZVT8nx6bj-rCfsXxz6YBDQ74AGVG4I2aDW-YADA0-yCi1QBbU2UKRbbutnGZD3-f2uiT3Z0kDfY3bnZ23TXf6z-BPOnvOY</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Roberts, James</creator><creator>Cheng, Jeanette D</creator><creator>Moore, Elizabeth</creator><creator>Ransom, Carla</creator><creator>Ma, Minhui</creator><creator>Rogers, Beverly B</creator><general>SAGE Publications</general><general>Sage</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling</title><author>Roberts, James ; Cheng, Jeanette D ; Moore, Elizabeth ; Ransom, Carla ; Ma, Minhui ; Rogers, Beverly B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-b0202ef6bb927f99d49b0754a59cc0e080d6d401c19b7d9bb38d0286c34637403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>COVID-19 - transmission</topic><topic>COVID-19 - virology</topic><topic>Female</topic><topic>Fibrin - metabolism</topic><topic>Histiocytosis - pathology</topic><topic>Histiocytosis - virology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infant, Newborn</topic><topic>Life Sciences & Biomedicine</topic><topic>Pathology</topic><topic>Pediatrics</topic><topic>Placenta - pathology</topic><topic>Placenta - virology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - pathology</topic><topic>Pregnancy Complications, Infectious - virology</topic><topic>SARS-CoV-2 - physiology</topic><topic>Science & Technology</topic><topic>Trophoblasts - pathology</topic><topic>Trophoblasts - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, James</creatorcontrib><creatorcontrib>Cheng, Jeanette D</creatorcontrib><creatorcontrib>Moore, Elizabeth</creatorcontrib><creatorcontrib>Ransom, Carla</creatorcontrib><creatorcontrib>Ma, Minhui</creatorcontrib><creatorcontrib>Rogers, Beverly B</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric and developmental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, James</au><au>Cheng, Jeanette D</au><au>Moore, Elizabeth</au><au>Ransom, Carla</au><au>Ma, Minhui</au><au>Rogers, Beverly B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling</atitle><jtitle>Pediatric and developmental pathology</jtitle><stitle>PEDIATR DEVEL PATHOL</stitle><addtitle>Pediatr Dev Pathol</addtitle><date>2021-11</date><risdate>2021</risdate><volume>24</volume><issue>6</issue><spage>581</spage><epage>584</epage><pages>581-584</pages><artnum>10935266211025122</artnum><issn>1093-5266</issn><eissn>1615-5742</eissn><abstract>Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. 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| subjects | Adult COVID-19 - transmission COVID-19 - virology Female Fibrin - metabolism Histiocytosis - pathology Histiocytosis - virology Humans Immunohistochemistry Infant, Newborn Life Sciences & Biomedicine Pathology Pediatrics Placenta - pathology Placenta - virology Pregnancy Pregnancy Complications, Infectious - pathology Pregnancy Complications, Infectious - virology SARS-CoV-2 - physiology Science & Technology Trophoblasts - pathology Trophoblasts - virology |
| title | Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling |
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