Immunobiology and conflicting roles of the human CD161 receptor in T cells
Human C‐type lectin‐like CD161 is a type‐II transmembrane protein expressed on the surface of various lymphocytes across innate and adaptive immune systems. CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut. Independently of function, CD161 was u...
Gespeichert in:
| Veröffentlicht in: | Scandinavian journal of immunology 2021-09, Vol.94 (3), p.e13090-n/a, Article 13090 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 3 |
| container_start_page | e13090 |
| container_title | Scandinavian journal of immunology |
| container_volume | 94 |
| creator | Wyrożemski, Łukasz Qiao, Shuo‐Wang |
| description | Human C‐type lectin‐like CD161 is a type‐II transmembrane protein expressed on the surface of various lymphocytes across innate and adaptive immune systems. CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut. Independently of function, CD161 was used as marker of innate‐like T cells and marker of IL‐17‐producing cells. The function of CD161 is still not fully understood. In T cells, CD161 was proposed to act as co‐signalling receptor that influence T‐cell receptor‐dependent responses. However, conflicting studies were published demonstrating lack of agreement over the role of CD161 during T‐cell activation. In this review, we outline phenotypical and functional consequences of CD161 expression in T cells. We provide critical discussion over the most pressing issues including in depth evaluation of the literature concerning CD161 putative co‐signalling properties. |
| doi_str_mv | 10.1111/sji.13090 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000668361900001CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2669504216</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4120-17b8070cd5c3f6a3b4b2e99befbf7807b4af8a4fef066a70640e8c293a5b65a3</originalsourceid><addsrcrecordid>eNqNkU9vFCEYh4nR2LV68AsoiReNmfYFBmY4mvHfNk08uHcCLLRsZmCFmTT77aXutgcTE7lAwvO-7wM_hF4TuCB1XZZduCAMJDxBK8IEbxj07ClaAQNoZNvxM_SilB0AYbRjz9EZ44IQ0dEVulpP0xKTCWlMNwes4xbbFP0Y7BziDc5pdAUnj-dbh2-XSUc8fCaC4Oys288p4xDxBls3juUleub1WNyr036ONl-_bIbvzfWPb-vh03VjW0KhIZ3poQO75ZZ5oZlpDXVSGueN7-qNabXvdeudByF0B6IF11sqmeZGcM3O0dtjW5tDqZIqpqwVgZ5TJRmhpBLvj8Q-p1-LK7OaQrlX1NGlpSgqhOTQUiIq-u4vdJeWHKu-opxL3natkJX68DAylZKdV_scJp0Pday6T0DVBNSfBCr75tRxMZPbPpIPX16B_gjcOZN8scFF6x4xgPrqngki6wnIEGY9hxSHtMS5ln78_9JKX57oMLrDv5XVz6v10f03ptes4g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559547469</pqid></control><display><type>article</type><title>Immunobiology and conflicting roles of the human CD161 receptor in T cells</title><source>MEDLINE</source><source>NORA - Norwegian Open Research Archives</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Wiley Online Library All Journals</source><creator>Wyrożemski, Łukasz ; Qiao, Shuo‐Wang</creator><creatorcontrib>Wyrożemski, Łukasz ; Qiao, Shuo‐Wang</creatorcontrib><description>Human C‐type lectin‐like CD161 is a type‐II transmembrane protein expressed on the surface of various lymphocytes across innate and adaptive immune systems. CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut. Independently of function, CD161 was used as marker of innate‐like T cells and marker of IL‐17‐producing cells. The function of CD161 is still not fully understood. In T cells, CD161 was proposed to act as co‐signalling receptor that influence T‐cell receptor‐dependent responses. However, conflicting studies were published demonstrating lack of agreement over the role of CD161 during T‐cell activation. In this review, we outline phenotypical and functional consequences of CD161 expression in T cells. We provide critical discussion over the most pressing issues including in depth evaluation of the literature concerning CD161 putative co‐signalling properties.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/sji.13090</identifier><identifier>PMID: 35611672</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>CD161 ; CD161+ T cells ; Cell activation ; Cytokines - metabolism ; Humans ; Immunology ; Life Sciences & Biomedicine ; LLT1 ; Lymphocyte Activation ; Lymphocyte Count ; Lymphocytes ; Lymphocytes T ; NK Cell Lectin-Like Receptor Subfamily B - metabolism ; Science & Technology ; T-Lymphocytes</subject><ispartof>Scandinavian journal of immunology, 2021-09, Vol.94 (3), p.e13090-n/a, Article 13090</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology</rights><rights>2021 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000668361900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4120-17b8070cd5c3f6a3b4b2e99befbf7807b4af8a4fef066a70640e8c293a5b65a3</citedby><cites>FETCH-LOGICAL-c4120-17b8070cd5c3f6a3b4b2e99befbf7807b4af8a4fef066a70640e8c293a5b65a3</cites><orcidid>0000-0003-3830-5064</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsji.13090$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsji.13090$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,1418,1434,26572,27929,27930,39263,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35611672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wyrożemski, Łukasz</creatorcontrib><creatorcontrib>Qiao, Shuo‐Wang</creatorcontrib><title>Immunobiology and conflicting roles of the human CD161 receptor in T cells</title><title>Scandinavian journal of immunology</title><addtitle>SCAND J IMMUNOL</addtitle><addtitle>Scand J Immunol</addtitle><description>Human C‐type lectin‐like CD161 is a type‐II transmembrane protein expressed on the surface of various lymphocytes across innate and adaptive immune systems. CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut. Independently of function, CD161 was used as marker of innate‐like T cells and marker of IL‐17‐producing cells. The function of CD161 is still not fully understood. In T cells, CD161 was proposed to act as co‐signalling receptor that influence T‐cell receptor‐dependent responses. However, conflicting studies were published demonstrating lack of agreement over the role of CD161 during T‐cell activation. In this review, we outline phenotypical and functional consequences of CD161 expression in T cells. We provide critical discussion over the most pressing issues including in depth evaluation of the literature concerning CD161 putative co‐signalling properties.</description><subject>CD161</subject><subject>CD161+ T cells</subject><subject>Cell activation</subject><subject>Cytokines - metabolism</subject><subject>Humans</subject><subject>Immunology</subject><subject>Life Sciences & Biomedicine</subject><subject>LLT1</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>NK Cell Lectin-Like Receptor Subfamily B - metabolism</subject><subject>Science & Technology</subject><subject>T-Lymphocytes</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>3HK</sourceid><recordid>eNqNkU9vFCEYh4nR2LV68AsoiReNmfYFBmY4mvHfNk08uHcCLLRsZmCFmTT77aXutgcTE7lAwvO-7wM_hF4TuCB1XZZduCAMJDxBK8IEbxj07ClaAQNoZNvxM_SilB0AYbRjz9EZ44IQ0dEVulpP0xKTCWlMNwes4xbbFP0Y7BziDc5pdAUnj-dbh2-XSUc8fCaC4Oys288p4xDxBls3juUleub1WNyr036ONl-_bIbvzfWPb-vh03VjW0KhIZ3poQO75ZZ5oZlpDXVSGueN7-qNabXvdeudByF0B6IF11sqmeZGcM3O0dtjW5tDqZIqpqwVgZ5TJRmhpBLvj8Q-p1-LK7OaQrlX1NGlpSgqhOTQUiIq-u4vdJeWHKu-opxL3natkJX68DAylZKdV_scJp0Pday6T0DVBNSfBCr75tRxMZPbPpIPX16B_gjcOZN8scFF6x4xgPrqngki6wnIEGY9hxSHtMS5ln78_9JKX57oMLrDv5XVz6v10f03ptes4g</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Wyrożemski, Łukasz</creator><creator>Qiao, Shuo‐Wang</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><general>Blackwell Science Ltd</general><scope>24P</scope><scope>WIN</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>3HK</scope><orcidid>https://orcid.org/0000-0003-3830-5064</orcidid></search><sort><creationdate>202109</creationdate><title>Immunobiology and conflicting roles of the human CD161 receptor in T cells</title><author>Wyrożemski, Łukasz ; Qiao, Shuo‐Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4120-17b8070cd5c3f6a3b4b2e99befbf7807b4af8a4fef066a70640e8c293a5b65a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>CD161</topic><topic>CD161+ T cells</topic><topic>Cell activation</topic><topic>Cytokines - metabolism</topic><topic>Humans</topic><topic>Immunology</topic><topic>Life Sciences & Biomedicine</topic><topic>LLT1</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>NK Cell Lectin-Like Receptor Subfamily B - metabolism</topic><topic>Science & Technology</topic><topic>T-Lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wyrożemski, Łukasz</creatorcontrib><creatorcontrib>Qiao, Shuo‐Wang</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wyrożemski, Łukasz</au><au>Qiao, Shuo‐Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunobiology and conflicting roles of the human CD161 receptor in T cells</atitle><jtitle>Scandinavian journal of immunology</jtitle><stitle>SCAND J IMMUNOL</stitle><addtitle>Scand J Immunol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>94</volume><issue>3</issue><spage>e13090</spage><epage>n/a</epage><pages>e13090-n/a</pages><artnum>13090</artnum><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>Human C‐type lectin‐like CD161 is a type‐II transmembrane protein expressed on the surface of various lymphocytes across innate and adaptive immune systems. CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut. Independently of function, CD161 was used as marker of innate‐like T cells and marker of IL‐17‐producing cells. The function of CD161 is still not fully understood. In T cells, CD161 was proposed to act as co‐signalling receptor that influence T‐cell receptor‐dependent responses. However, conflicting studies were published demonstrating lack of agreement over the role of CD161 during T‐cell activation. In this review, we outline phenotypical and functional consequences of CD161 expression in T cells. We provide critical discussion over the most pressing issues including in depth evaluation of the literature concerning CD161 putative co‐signalling properties.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>35611672</pmid><doi>10.1111/sji.13090</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3830-5064</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9475 |
| ispartof | Scandinavian journal of immunology, 2021-09, Vol.94 (3), p.e13090-n/a, Article 13090 |
| issn | 0300-9475 1365-3083 |
| language | eng |
| recordid | cdi_webofscience_primary_000668361900001CitationCount |
| source | MEDLINE; NORA - Norwegian Open Research Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Wiley Online Library All Journals |
| subjects | CD161 CD161+ T cells Cell activation Cytokines - metabolism Humans Immunology Life Sciences & Biomedicine LLT1 Lymphocyte Activation Lymphocyte Count Lymphocytes Lymphocytes T NK Cell Lectin-Like Receptor Subfamily B - metabolism Science & Technology T-Lymphocytes |
| title | Immunobiology and conflicting roles of the human CD161 receptor in T cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T07%3A26%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunobiology%20and%20conflicting%20roles%20of%20the%20human%20CD161%20receptor%20in%20T%20cells&rft.jtitle=Scandinavian%20journal%20of%20immunology&rft.au=Wyro%C5%BCemski,%20%C5%81ukasz&rft.date=2021-09&rft.volume=94&rft.issue=3&rft.spage=e13090&rft.epage=n/a&rft.pages=e13090-n/a&rft.artnum=13090&rft.issn=0300-9475&rft.eissn=1365-3083&rft_id=info:doi/10.1111/sji.13090&rft_dat=%3Cproquest_webof%3E2669504216%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2559547469&rft_id=info:pmid/35611672&rfr_iscdi=true |