Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice

Atherosclerosis is a serious age-related pathology, and one of its hallmarks is the presence of chronic inflammation. Sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) is a cholesterol sensor that plays an essential role in regulating intracellular cholesterol home...

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Veröffentlicht in:	Aging and disease 2021-06, Vol.12 (3), p.747-763
Hauptverfasser:	Li, Danyang, Liu, Mihua, Li, Zhe, Zheng, Guo, Chen, Amei, Zhao, Lei, Yang, Ping, Wei, Li, Chen, Yaxi, Ruan, Xiong Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Carrier proteins Development and progression Health aspects Orginal Physiological aspects Vascular smooth muscle
Online-Zugang:	Volltext
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