Recurrence of primary sclerosing cholangitis after liver transplantation – analysing the European Liver Transplant Registry and beyond
Summary Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post‐transplant rPSC on graft and patient survival in a large Euro...
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| Veröffentlicht in: | Transplant international 2021-08, Vol.34 (8), p.1455-1467 |
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| creator | Visseren, Thijmen Erler, Nicole Stephanie Polak, Wojciech Grzegorz Adam, René Karam, Vincent Vondran, Florian Wolfgang Rudolf Ericzon, Bo‐Goran Thorburn, Douglas IJzermans, Jan Nicolaas Maria Paul, Andreas Heide, Frans Taimr, Pavel Nemec, Petr Pirenne, Jacques Romagnoli, Renato Metselaar, Herold Johnny Darwish Murad, Sarwa Vondran, Florian Bergquist, Annika Lindström, Lina Snowdon, Victoria Paul, Andreas van der Heide, Frans Trunecka, Pavel Pirenne, Jacques Salizzoni, Mauro Arendtsen Rostved, Andreas Arenga, Giuseppe Berlakovich, Gabriela A Candinas, Daniel Markovic, Sasa Troisi, Roberto van Hoek, Bart Kanmaz, Turan Dayangac, Murat Berney, Thierry Sforza, Daniele Gridelli, Bruno Clavien, Pierre‐Alain Hoppe‐Lotichius, Maria Senninger, Norbert Lorf, Thomas Settmacher, Utz Cuervas‐Mons, Valentín Bacakoğlu, Aylin Nadalin, Silvio Serra, Valentina Pacholczyk, Marek Baccarani, Umberto Dopazo Taboada, Cristina Berenguer, Marina San Juan, Fernando Detry, Olivier Stippel, Dirk Evrard, Philippe Gugenheim, Jean Kiliç, Murat Fernández Selles, Carlos Norena, Luis Antonio Herrera Melandro, Fabio Gonzalez‐Pinto, Ignacio Nicolini, Daniele Pardo Sánchez, Fernando Neumann‐Haefelin, Christoph |
| description | Summary
Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post‐transplant rPSC on graft and patient survival in a large European cohort. Registry data from the European Liver Transplant Registry regarding all first transplants for PSC between 1980 and 2015 were supplemented with detailed data on rPSC from 48 out of 138 contributing transplant centres, involving 1,549 patients. Bayesian proportional hazards models were used to investigate the impact of rPSC and other covariates on patient and graft survival. Recurrence of PSC was diagnosed in 259 patients (16.7%) after a median follow‐up of 5.0 years (quantile 2.5%‐97.5%: 0.4–18.5), with a significant negative impact on both graft (HR 6.7; 95% CI 4.9–9.1) and patient survival (HR 2.3; 95% CI 1.5–3.3). Patients with rPSC underwent significantly more re‐transplants than those without rPSC (OR 3.6, 95% CI 2.7–4.8). PSC recurrence has a negative impact on both graft and patient survival, independent of transplant‐related covariates. Recurrence of PSC leads to higher number of re‐transplantations and a 33% decrease in 10‐year graft survival.
Recurrence of PSC negatively impacts both graft and patient survival–an European Liver Transplant Registry study |
| doi_str_mv | 10.1111/tri.13925 |
| format | Article |
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Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post‐transplant rPSC on graft and patient survival in a large European cohort. Registry data from the European Liver Transplant Registry regarding all first transplants for PSC between 1980 and 2015 were supplemented with detailed data on rPSC from 48 out of 138 contributing transplant centres, involving 1,549 patients. Bayesian proportional hazards models were used to investigate the impact of rPSC and other covariates on patient and graft survival. Recurrence of PSC was diagnosed in 259 patients (16.7%) after a median follow‐up of 5.0 years (quantile 2.5%‐97.5%: 0.4–18.5), with a significant negative impact on both graft (HR 6.7; 95% CI 4.9–9.1) and patient survival (HR 2.3; 95% CI 1.5–3.3). Patients with rPSC underwent significantly more re‐transplants than those without rPSC (OR 3.6, 95% CI 2.7–4.8). PSC recurrence has a negative impact on both graft and patient survival, independent of transplant‐related covariates. Recurrence of PSC leads to higher number of re‐transplantations and a 33% decrease in 10‐year graft survival.
Recurrence of PSC negatively impacts both graft and patient survival–an European Liver Transplant Registry study</description><identifier>ISSN: 0934-0874</identifier><identifier>ISSN: 1432-2277</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/tri.13925</identifier><identifier>PMID: 34028110</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Bayes Theorem ; Bayesian analysis ; bayesian statistics ; Chirurgie ; Cholangitis ; Cholangitis, Sclerosing/surgery ; Clinical Science ; disease recurrence ; Gastroenterology & hepatology ; Gastroentérologie & hépatologie ; Grafting ; Human health sciences ; Humans ; Life Sciences & Biomedicine ; Liver ; Liver transplantation ; Liver Transplantation/adverse effects ; Liver transplants ; Mathematical models ; Medicin och hälsovetenskap ; Original ; patient and graft survival ; Patients ; primary sclerosing cholangitis ; Recurrence ; Registries ; Retrospective Studies ; Risk Factors ; Science & Technology ; Sciences de la santé humaine ; Statistical models ; Surgery ; Survival ; Transplantation ; Transplants</subject><ispartof>Transplant international, 2021-08, Vol.34 (8), p.1455-1467</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT</rights><rights>2021. 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Rudolf</creatorcontrib><creatorcontrib>Ericzon, Bo‐Goran</creatorcontrib><creatorcontrib>Thorburn, Douglas</creatorcontrib><creatorcontrib>IJzermans, Jan Nicolaas Maria</creatorcontrib><creatorcontrib>Paul, Andreas</creatorcontrib><creatorcontrib>Heide, Frans</creatorcontrib><creatorcontrib>Taimr, Pavel</creatorcontrib><creatorcontrib>Nemec, Petr</creatorcontrib><creatorcontrib>Pirenne, Jacques</creatorcontrib><creatorcontrib>Romagnoli, Renato</creatorcontrib><creatorcontrib>Metselaar, Herold Johnny</creatorcontrib><creatorcontrib>Darwish Murad, Sarwa</creatorcontrib><creatorcontrib>Vondran, Florian</creatorcontrib><creatorcontrib>Bergquist, Annika</creatorcontrib><creatorcontrib>Lindström, Lina</creatorcontrib><creatorcontrib>Snowdon, Victoria</creatorcontrib><creatorcontrib>Paul, Andreas</creatorcontrib><creatorcontrib>van der Heide, Frans</creatorcontrib><creatorcontrib>Trunecka, Pavel</creatorcontrib><creatorcontrib>Pirenne, Jacques</creatorcontrib><creatorcontrib>Salizzoni, Mauro</creatorcontrib><creatorcontrib>Arendtsen Rostved, Andreas</creatorcontrib><creatorcontrib>Arenga, Giuseppe</creatorcontrib><creatorcontrib>Berlakovich, Gabriela A</creatorcontrib><creatorcontrib>Candinas, Daniel</creatorcontrib><creatorcontrib>Markovic, Sasa</creatorcontrib><creatorcontrib>Troisi, Roberto</creatorcontrib><creatorcontrib>van Hoek, Bart</creatorcontrib><creatorcontrib>Kanmaz, Turan</creatorcontrib><creatorcontrib>Dayangac, Murat</creatorcontrib><creatorcontrib>Berney, Thierry</creatorcontrib><creatorcontrib>Sforza, Daniele</creatorcontrib><creatorcontrib>Gridelli, Bruno</creatorcontrib><creatorcontrib>Clavien, Pierre‐Alain</creatorcontrib><creatorcontrib>Hoppe‐Lotichius, Maria</creatorcontrib><creatorcontrib>Senninger, Norbert</creatorcontrib><creatorcontrib>Lorf, Thomas</creatorcontrib><creatorcontrib>Settmacher, Utz</creatorcontrib><creatorcontrib>Cuervas‐Mons, Valentín</creatorcontrib><creatorcontrib>Bacakoğlu, Aylin</creatorcontrib><creatorcontrib>Nadalin, Silvio</creatorcontrib><creatorcontrib>Serra, Valentina</creatorcontrib><creatorcontrib>Pacholczyk, Marek</creatorcontrib><creatorcontrib>Baccarani, Umberto</creatorcontrib><creatorcontrib>Dopazo Taboada, Cristina</creatorcontrib><creatorcontrib>Berenguer, Marina</creatorcontrib><creatorcontrib>San Juan, Fernando</creatorcontrib><creatorcontrib>Detry, Olivier</creatorcontrib><creatorcontrib>Stippel, Dirk</creatorcontrib><creatorcontrib>Evrard, Philippe</creatorcontrib><creatorcontrib>Gugenheim, Jean</creatorcontrib><creatorcontrib>Kiliç, Murat</creatorcontrib><creatorcontrib>Fernández Selles, Carlos</creatorcontrib><creatorcontrib>Norena, Luis Antonio Herrera</creatorcontrib><creatorcontrib>Melandro, Fabio</creatorcontrib><creatorcontrib>Gonzalez‐Pinto, Ignacio</creatorcontrib><creatorcontrib>Nicolini, Daniele</creatorcontrib><creatorcontrib>Pardo Sánchez, Fernando</creatorcontrib><creatorcontrib>Neumann‐Haefelin, Christoph</creatorcontrib><creatorcontrib>European Liver Intestine Transplan</creatorcontrib><creatorcontrib>for the European Liver and Intestine Transplantation Association (ELITA)</creatorcontrib><title>Recurrence of primary sclerosing cholangitis after liver transplantation – analysing the European Liver Transplant Registry and beyond</title><title>Transplant international</title><addtitle>TRANSPL INT</addtitle><description>Summary
Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post‐transplant rPSC on graft and patient survival in a large European cohort. Registry data from the European Liver Transplant Registry regarding all first transplants for PSC between 1980 and 2015 were supplemented with detailed data on rPSC from 48 out of 138 contributing transplant centres, involving 1,549 patients. Bayesian proportional hazards models were used to investigate the impact of rPSC and other covariates on patient and graft survival. Recurrence of PSC was diagnosed in 259 patients (16.7%) after a median follow‐up of 5.0 years (quantile 2.5%‐97.5%: 0.4–18.5), with a significant negative impact on both graft (HR 6.7; 95% CI 4.9–9.1) and patient survival (HR 2.3; 95% CI 1.5–3.3). Patients with rPSC underwent significantly more re‐transplants than those without rPSC (OR 3.6, 95% CI 2.7–4.8). PSC recurrence has a negative impact on both graft and patient survival, independent of transplant‐related covariates. Recurrence of PSC leads to higher number of re‐transplantations and a 33% decrease in 10‐year graft survival.
Recurrence of PSC negatively impacts both graft and patient survival–an European Liver Transplant Registry study</description><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>bayesian statistics</subject><subject>Chirurgie</subject><subject>Cholangitis</subject><subject>Cholangitis, Sclerosing/surgery</subject><subject>Clinical Science</subject><subject>disease recurrence</subject><subject>Gastroenterology & hepatology</subject><subject>Gastroentérologie & hépatologie</subject><subject>Grafting</subject><subject>Human health sciences</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver</subject><subject>Liver transplantation</subject><subject>Liver Transplantation/adverse effects</subject><subject>Liver transplants</subject><subject>Mathematical models</subject><subject>Medicin och hälsovetenskap</subject><subject>Original</subject><subject>patient and graft survival</subject><subject>Patients</subject><subject>primary sclerosing cholangitis</subject><subject>Recurrence</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Science & Technology</subject><subject>Sciences de la santé humaine</subject><subject>Statistical models</subject><subject>Surgery</subject><subject>Survival</subject><subject>Transplantation</subject><subject>Transplants</subject><issn>0934-0874</issn><issn>1432-2277</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>HGBXW</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk-L1DAYh4so7rp68BsUvCgyu_mf9CIsw6oLA8Iw95CmbztZO82YtLPMzaN3v6GfxHQ6jqywYA_tS_s8b5K3vyx7jdElTtdVH9wlpgXhT7JzzCiZESLl0-wcFZTNkJLsLHsR4x1CiCiOnmdnlKUKY3Se_ViCHUKAzkLu63wb3MaEfR5tC8FH1zW5XfvWdI3rXcxN3UPIW7dL9z6YLm7Tp970znf5r-8_c9OZdn-w-jXkN0PwWzBdvjgIq5OQL6FxsU_rmK7KS9j7rnqZPatNG-HV8XmRrT7erOafZ4svn27n14uZ5ZzwWQ11WSGlyrIgpMakZkJSS0DWxkpiZUWL0ipFTY0ZKipKCTFSipJyZbiq6EU2m9rGe9gOpT4eWHvj9PHV11SBZgKnCSW-eJTfBl_9lf6ImImCKEFEcj9MbgI2UFno0szahy0efOncWjd-pxXjQqGxAZ0atA4a0D6UTu_IQTzUQ9toY3UJmhChNFEFQSRZb4_LBv9tgNjrjYsW2jR58EPUhFPMKcNSJvTNP-idH0L6iSMlEKOC8XEG7ybKpkjEAPXpCBjpMYA6BVAfApjY9xN7D6Wvo3Vjsk58SqAQEgvBU4XGzur_6bmbkjb3Q9cn9eqouhb2j-9Ir5a309Z-A0wGAcY</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Visseren, 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Inc</general><scope>24P</scope><scope>WIN</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-3096-4893</orcidid><orcidid>https://orcid.org/0000-0003-2804-1165</orcidid><orcidid>https://orcid.org/0000-0001-8340-8885</orcidid><orcidid>https://orcid.org/0000-0002-7391-0190</orcidid><orcidid>https://orcid.org/0000-0002-7203-8126</orcidid><orcidid>https://orcid.org/0000-0003-4756-5095</orcidid></search><sort><creationdate>202108</creationdate><title>Recurrence of primary sclerosing cholangitis after liver transplantation – analysing the European Liver Transplant Registry and beyond</title><author>Visseren, Thijmen ; Erler, Nicole Stephanie ; Polak, Wojciech Grzegorz ; Adam, René ; Karam, Vincent ; Vondran, Florian Wolfgang Rudolf ; Ericzon, Bo‐Goran ; Thorburn, Douglas ; IJzermans, Jan Nicolaas Maria ; Paul, Andreas ; Heide, Frans ; Taimr, Pavel ; Nemec, Petr ; Pirenne, Jacques ; Romagnoli, Renato ; Metselaar, Herold Johnny ; Darwish Murad, Sarwa ; Vondran, Florian ; Bergquist, Annika ; Lindström, Lina ; Snowdon, Victoria ; Paul, Andreas ; van der Heide, Frans ; Trunecka, Pavel ; Pirenne, Jacques ; Salizzoni, Mauro ; Arendtsen Rostved, Andreas ; Arenga, Giuseppe ; Berlakovich, Gabriela A ; Candinas, Daniel ; Markovic, Sasa ; Troisi, Roberto ; van Hoek, Bart ; Kanmaz, Turan ; Dayangac, Murat ; Berney, Thierry ; Sforza, Daniele ; Gridelli, Bruno ; Clavien, Pierre‐Alain ; Hoppe‐Lotichius, Maria ; Senninger, Norbert ; Lorf, Thomas ; Settmacher, Utz ; Cuervas‐Mons, Valentín ; Bacakoğlu, Aylin ; Nadalin, Silvio ; Serra, Valentina ; Pacholczyk, Marek ; Baccarani, Umberto ; Dopazo Taboada, Cristina ; Berenguer, Marina ; San Juan, Fernando ; Detry, Olivier ; Stippel, Dirk ; Evrard, Philippe ; Gugenheim, Jean ; Kiliç, Murat ; Fernández Selles, Carlos ; Norena, Luis Antonio Herrera ; Melandro, Fabio ; Gonzalez‐Pinto, Ignacio ; Nicolini, Daniele ; Pardo Sánchez, Fernando ; Neumann‐Haefelin, Christoph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5525-fefbd088bb922f12f4673c2e7fac72c7d39bc883af1409d3322a776b358a58d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bayes Theorem</topic><topic>Bayesian analysis</topic><topic>bayesian statistics</topic><topic>Chirurgie</topic><topic>Cholangitis</topic><topic>Cholangitis, Sclerosing/surgery</topic><topic>Clinical Science</topic><topic>disease recurrence</topic><topic>Gastroenterology & hepatology</topic><topic>Gastroentérologie & hépatologie</topic><topic>Grafting</topic><topic>Human health sciences</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver</topic><topic>Liver transplantation</topic><topic>Liver Transplantation/adverse effects</topic><topic>Liver transplants</topic><topic>Mathematical models</topic><topic>Medicin och hälsovetenskap</topic><topic>Original</topic><topic>patient and graft survival</topic><topic>Patients</topic><topic>primary sclerosing cholangitis</topic><topic>Recurrence</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Science & Technology</topic><topic>Sciences de la santé humaine</topic><topic>Statistical models</topic><topic>Surgery</topic><topic>Survival</topic><topic>Transplantation</topic><topic>Transplants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visseren, Thijmen</creatorcontrib><creatorcontrib>Erler, Nicole Stephanie</creatorcontrib><creatorcontrib>Polak, Wojciech Grzegorz</creatorcontrib><creatorcontrib>Adam, René</creatorcontrib><creatorcontrib>Karam, Vincent</creatorcontrib><creatorcontrib>Vondran, Florian Wolfgang Rudolf</creatorcontrib><creatorcontrib>Ericzon, Bo‐Goran</creatorcontrib><creatorcontrib>Thorburn, Douglas</creatorcontrib><creatorcontrib>IJzermans, Jan Nicolaas Maria</creatorcontrib><creatorcontrib>Paul, Andreas</creatorcontrib><creatorcontrib>Heide, Frans</creatorcontrib><creatorcontrib>Taimr, Pavel</creatorcontrib><creatorcontrib>Nemec, Petr</creatorcontrib><creatorcontrib>Pirenne, Jacques</creatorcontrib><creatorcontrib>Romagnoli, Renato</creatorcontrib><creatorcontrib>Metselaar, Herold Johnny</creatorcontrib><creatorcontrib>Darwish Murad, Sarwa</creatorcontrib><creatorcontrib>Vondran, Florian</creatorcontrib><creatorcontrib>Bergquist, Annika</creatorcontrib><creatorcontrib>Lindström, Lina</creatorcontrib><creatorcontrib>Snowdon, Victoria</creatorcontrib><creatorcontrib>Paul, Andreas</creatorcontrib><creatorcontrib>van der Heide, Frans</creatorcontrib><creatorcontrib>Trunecka, Pavel</creatorcontrib><creatorcontrib>Pirenne, Jacques</creatorcontrib><creatorcontrib>Salizzoni, Mauro</creatorcontrib><creatorcontrib>Arendtsen Rostved, Andreas</creatorcontrib><creatorcontrib>Arenga, Giuseppe</creatorcontrib><creatorcontrib>Berlakovich, Gabriela A</creatorcontrib><creatorcontrib>Candinas, Daniel</creatorcontrib><creatorcontrib>Markovic, Sasa</creatorcontrib><creatorcontrib>Troisi, Roberto</creatorcontrib><creatorcontrib>van Hoek, Bart</creatorcontrib><creatorcontrib>Kanmaz, Turan</creatorcontrib><creatorcontrib>Dayangac, Murat</creatorcontrib><creatorcontrib>Berney, Thierry</creatorcontrib><creatorcontrib>Sforza, Daniele</creatorcontrib><creatorcontrib>Gridelli, Bruno</creatorcontrib><creatorcontrib>Clavien, Pierre‐Alain</creatorcontrib><creatorcontrib>Hoppe‐Lotichius, Maria</creatorcontrib><creatorcontrib>Senninger, Norbert</creatorcontrib><creatorcontrib>Lorf, Thomas</creatorcontrib><creatorcontrib>Settmacher, Utz</creatorcontrib><creatorcontrib>Cuervas‐Mons, Valentín</creatorcontrib><creatorcontrib>Bacakoğlu, Aylin</creatorcontrib><creatorcontrib>Nadalin, Silvio</creatorcontrib><creatorcontrib>Serra, Valentina</creatorcontrib><creatorcontrib>Pacholczyk, Marek</creatorcontrib><creatorcontrib>Baccarani, Umberto</creatorcontrib><creatorcontrib>Dopazo Taboada, Cristina</creatorcontrib><creatorcontrib>Berenguer, Marina</creatorcontrib><creatorcontrib>San Juan, Fernando</creatorcontrib><creatorcontrib>Detry, Olivier</creatorcontrib><creatorcontrib>Stippel, Dirk</creatorcontrib><creatorcontrib>Evrard, Philippe</creatorcontrib><creatorcontrib>Gugenheim, Jean</creatorcontrib><creatorcontrib>Kiliç, Murat</creatorcontrib><creatorcontrib>Fernández Selles, Carlos</creatorcontrib><creatorcontrib>Norena, Luis Antonio Herrera</creatorcontrib><creatorcontrib>Melandro, Fabio</creatorcontrib><creatorcontrib>Gonzalez‐Pinto, Ignacio</creatorcontrib><creatorcontrib>Nicolini, Daniele</creatorcontrib><creatorcontrib>Pardo Sánchez, Fernando</creatorcontrib><creatorcontrib>Neumann‐Haefelin, Christoph</creatorcontrib><creatorcontrib>European Liver Intestine Transplan</creatorcontrib><creatorcontrib>for the European Liver and Intestine Transplantation Association (ELITA)</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visseren, Thijmen</au><au>Erler, Nicole Stephanie</au><au>Polak, Wojciech Grzegorz</au><au>Adam, René</au><au>Karam, Vincent</au><au>Vondran, Florian Wolfgang Rudolf</au><au>Ericzon, Bo‐Goran</au><au>Thorburn, Douglas</au><au>IJzermans, Jan Nicolaas Maria</au><au>Paul, Andreas</au><au>Heide, Frans</au><au>Taimr, Pavel</au><au>Nemec, Petr</au><au>Pirenne, Jacques</au><au>Romagnoli, Renato</au><au>Metselaar, Herold Johnny</au><au>Darwish Murad, Sarwa</au><au>Vondran, Florian</au><au>Bergquist, Annika</au><au>Lindström, Lina</au><au>Snowdon, Victoria</au><au>Paul, Andreas</au><au>van der Heide, Frans</au><au>Trunecka, Pavel</au><au>Pirenne, Jacques</au><au>Salizzoni, Mauro</au><au>Arendtsen Rostved, Andreas</au><au>Arenga, Giuseppe</au><au>Berlakovich, Gabriela A</au><au>Candinas, Daniel</au><au>Markovic, Sasa</au><au>Troisi, Roberto</au><au>van Hoek, Bart</au><au>Kanmaz, Turan</au><au>Dayangac, Murat</au><au>Berney, Thierry</au><au>Sforza, Daniele</au><au>Gridelli, Bruno</au><au>Clavien, Pierre‐Alain</au><au>Hoppe‐Lotichius, Maria</au><au>Senninger, Norbert</au><au>Lorf, Thomas</au><au>Settmacher, Utz</au><au>Cuervas‐Mons, Valentín</au><au>Bacakoğlu, Aylin</au><au>Nadalin, Silvio</au><au>Serra, Valentina</au><au>Pacholczyk, Marek</au><au>Baccarani, Umberto</au><au>Dopazo Taboada, Cristina</au><au>Berenguer, Marina</au><au>San Juan, Fernando</au><au>Detry, Olivier</au><au>Stippel, Dirk</au><au>Evrard, Philippe</au><au>Gugenheim, Jean</au><au>Kiliç, Murat</au><au>Fernández Selles, Carlos</au><au>Norena, Luis Antonio Herrera</au><au>Melandro, Fabio</au><au>Gonzalez‐Pinto, Ignacio</au><au>Nicolini, Daniele</au><au>Pardo Sánchez, Fernando</au><au>Neumann‐Haefelin, Christoph</au><aucorp>European Liver Intestine Transplan</aucorp><aucorp>for the European Liver and Intestine Transplantation Association (ELITA)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrence of primary sclerosing cholangitis after liver transplantation – analysing the European Liver Transplant Registry and beyond</atitle><jtitle>Transplant international</jtitle><stitle>TRANSPL INT</stitle><date>2021-08</date><risdate>2021</risdate><volume>34</volume><issue>8</issue><spage>1455</spage><epage>1467</epage><pages>1455-1467</pages><issn>0934-0874</issn><issn>1432-2277</issn><eissn>1432-2277</eissn><abstract>Summary
Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post‐transplant rPSC on graft and patient survival in a large European cohort. Registry data from the European Liver Transplant Registry regarding all first transplants for PSC between 1980 and 2015 were supplemented with detailed data on rPSC from 48 out of 138 contributing transplant centres, involving 1,549 patients. Bayesian proportional hazards models were used to investigate the impact of rPSC and other covariates on patient and graft survival. Recurrence of PSC was diagnosed in 259 patients (16.7%) after a median follow‐up of 5.0 years (quantile 2.5%‐97.5%: 0.4–18.5), with a significant negative impact on both graft (HR 6.7; 95% CI 4.9–9.1) and patient survival (HR 2.3; 95% CI 1.5–3.3). Patients with rPSC underwent significantly more re‐transplants than those without rPSC (OR 3.6, 95% CI 2.7–4.8). PSC recurrence has a negative impact on both graft and patient survival, independent of transplant‐related covariates. Recurrence of PSC leads to higher number of re‐transplantations and a 33% decrease in 10‐year graft survival.
Recurrence of PSC negatively impacts both graft and patient survival–an European Liver Transplant Registry study</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>34028110</pmid><doi>10.1111/tri.13925</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3096-4893</orcidid><orcidid>https://orcid.org/0000-0003-2804-1165</orcidid><orcidid>https://orcid.org/0000-0001-8340-8885</orcidid><orcidid>https://orcid.org/0000-0002-7391-0190</orcidid><orcidid>https://orcid.org/0000-0002-7203-8126</orcidid><orcidid>https://orcid.org/0000-0003-4756-5095</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 2021-08, Vol.34 (8), p.1455-1467 |
| issn | 0934-0874 1432-2277 1432-2277 |
| language | eng |
| recordid | cdi_webofscience_primary_000667166500001CitationCount |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Access via Wiley Online Library; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Bayes Theorem Bayesian analysis bayesian statistics Chirurgie Cholangitis Cholangitis, Sclerosing/surgery Clinical Science disease recurrence Gastroenterology & hepatology Gastroentérologie & hépatologie Grafting Human health sciences Humans Life Sciences & Biomedicine Liver Liver transplantation Liver Transplantation/adverse effects Liver transplants Mathematical models Medicin och hälsovetenskap Original patient and graft survival Patients primary sclerosing cholangitis Recurrence Registries Retrospective Studies Risk Factors Science & Technology Sciences de la santé humaine Statistical models Surgery Survival Transplantation Transplants |
| title | Recurrence of primary sclerosing cholangitis after liver transplantation – analysing the European Liver Transplant Registry and beyond |
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