Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019
Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease s...
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| Veröffentlicht in: | Viruses 2021-06, Vol.13 (6), p.1152, Article 1152 |
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| creator | Soe, Aung Min Ngwe Tun, Mya Myat Nabeshima, Takeshi Myat, Theingi Win Htun, Moh Moh Lin, Htin Hom, Nang Sarm Inoue, Shingo Nwe, Khine Mya Aye, Lynn Pa Pa Fukuta, Mizuki Thant, Kyaw Zin Hasebe, Futoshi Morita, Kouichi Shresta, Sujan Thu, Hlaing Myat Moi, Meng Ling |
| description | Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1-4 demonstrated that most DENV-1-4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions. |
| doi_str_mv | 10.3390/v13061152 |
| format | Article |
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It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1-4 demonstrated that most DENV-1-4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions.</description><identifier>ISSN: 1999-4915</identifier><identifier>EISSN: 1999-4915</identifier><identifier>DOI: 10.3390/v13061152</identifier><identifier>PMID: 34208667</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Amino acids ; Cloning ; co-circulation ; Dengue fever ; dengue outbreak ; DENV-3 ; Epidemics ; Fever ; Genomes ; Genotype & phenotype ; genotype-1 ; Genotypes ; Infections ; Life Sciences & Biomedicine ; Myanmar ; Phylogenetics ; Public health ; Science & Technology ; Serology ; Serotypes ; Strains (organisms) ; Variance analysis ; Virology ; Viruses ; Whole genome sequencing</subject><ispartof>Viruses, 2021-06, Vol.13 (6), p.1152, Article 1152</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. 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| subjects | Amino acids Cloning co-circulation Dengue fever dengue outbreak DENV-3 Epidemics Fever Genomes Genotype & phenotype genotype-1 Genotypes Infections Life Sciences & Biomedicine Myanmar Phylogenetics Public health Science & Technology Serology Serotypes Strains (organisms) Variance analysis Virology Viruses Whole genome sequencing |
| title | Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 |
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