Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats

Relapse susceptibility in women with substance use disorders (SUDs) has been linked to the estrogen, 17β-estradiol (E2). Our previous findings in female rats suggest that the influence of E2 on cocaine seeking can be localized to the prelimbic prefrontal cortex (PrL-PFC). Here, we investigated the r...

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Veröffentlicht in:	The Journal of neuroscience 2021-06, Vol.41 (24), p.5303-5314
Hauptverfasser:	Doncheck, Elizabeth M, Anderson, Eden M, Konrath, Chaz D, Liddiard, Gage T, DeBaker, Margot C, Urbanik, Luke A, Hearing, Matthew C, Mantsch, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Agonists Animals Cocaine Cocaine-Related Disorders - metabolism Dosage Drug self-administration Drug-Seeking Behavior - physiology Estradiol - metabolism Estrogen Receptor beta - metabolism Estrogen receptors Estrogens Extinction, Psychological - physiology Female Inhibitory postsynaptic potentials Intravenous administration Ovariectomy Prefrontal cortex Prefrontal Cortex - metabolism Priming Pyramidal cells Rats Rats, Sprague-Dawley Receptor mechanisms Receptors Receptors, G-Protein-Coupled - metabolism Reinstatement Rodents Sex hormones Substance use γ-Aminobutyric acid A receptors
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