Kaolin-catalysed one-pot synthesis of thiophene containing aminonaphthols under solvent-free condition and their in vitro anticancer and antioxidant activity

An efficient and eco-friendly synthetic protocol via a one-pot three-component reaction to yield thiophene containing aminonaphthols (Betti bases) is reported. Kaolin was used as a heterogeneous catalyst and a series of Betti bases were synthesized under solvent-free condition. The synthesized derivatives were characterized by various techniques, viz. FTIR, 1 H-NMR, 13 C-NMR, mass spectrometry and elemental analysis. The synthesized compounds were screened for in vitro anticancer and antioxidant activities. Compounds 4d , 4i , 4j exhibited excellent anticancer activity (GI 50