Collagen Characterization in a Model of Nonalcoholic Steatohepatitis with Fibrosis; A Call for Development of Targeted Therapeutics

Left untreated, nonalcoholic fatty liver disease can progress to nonalcoholic steatohepatitis (NASH), fibrosis, and end-stage liver disease. To date, few if any therapies have proven effective against NASH with fibrosis. Quantification and qualification of hepatic scar might enable development of mo...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-06, Vol.26 (11), p.3316
Hauptverfasser:	Pellicano, Anthony J., Spahn, Kiera, Zhou, Ping, Goldberg, Itzhak D., Narayan, Prakash
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biomarkers Biopsy Collagen Collagen (type I) collagen type III Deposition Drug development Extracellular matrix Fatty liver Fibrosis Gene expression Hydroxyproline Hypotheses Inflammation Liver Liver diseases Microscopic analysis Microscopy NASH Parenchyma Patients precision therapeutics Scars Stains & staining Tissue analysis transcriptomic Transplants & implants
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