Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

Mavacamten (MYK-461) is a small-molecule allosteric inhibitor of sarcomeric myosins being used in preclinical/clinical trials for hypertrophic cardiomyopathy treatment. A better understanding of its impact on force generation in intact or skinned striated muscle preparations, especially for human ca...

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Veröffentlicht in:	The Journal of general physiology 2021-07, Vol.153 (7), p.1, Article 202012789
Hauptverfasser:	Scellini, Beatrice, Piroddi, Nicoletta, Dente, Marica, Vitale, Giulia, Pioner, Jose Manuel, Coppini, Raffaele, Ferrantini, Cecilia, Poggesi, Corrado, Tesi, Chiara
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Allosteric properties Biophysics Calcium Cardiac muscle Cardiomyopathy Clinical trials Contraction Contraction and cell motility Life Sciences & Biomedicine Molecular pharmacology Molecular physiology Muscle contraction Myofibrils Myofilament Special Issue, 2020 Myosin Physiology Science & Technology Skeletal muscle Ventricle
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