Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial

Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial

Objective To determine whether serum urate reduction with allopurinol lowers blood pressure (BP) in young adults and the mechanisms mediating this hypothesized effect. Methods We conducted a single‐center, randomized, double‐blind, crossover clinical trial. Adults ages 18–40 years with baseline syst...

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Veröffentlicht in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2021-08, Vol.73 (8), p.1514-1522
Hauptverfasser: Gaffo, Angelo L., Calhoun, David A., Rahn, Elizabeth J., Oparil, Suzanne, Li, Peng, Dudenbostel, Tanja, Feig, Daniel I., Redden, David T., Muntner, Paul, Foster, Phillip J., Biggers‐Clark, Stephanie R., Mudano, Amy, Sattui, Sebastian E., Saddekni, Michael B., Bridges, S. Louis, Saag, Kenneth G.
Format: Artikel
Sprache:eng
Schlagworte:
Adults
Adverse events
Allopurinol
Blood pressure
Clinical trials
Gout
Health services
Hypertension
Kidney diseases
Life Sciences & Biomedicine
Men
Placebos
Rheumatology
Science & Technology
Uric acid
Young adults
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Zusammenfassung:Objective To determine whether serum urate reduction with allopurinol lowers blood pressure (BP) in young adults and the mechanisms mediating this hypothesized effect. Methods We conducted a single‐center, randomized, double‐blind, crossover clinical trial. Adults ages 18–40 years with baseline systolic BP ≥120 and
ISSN:2326-5191
2326-5205
DOI:10.1002/art.41749