Three-component reaction of gem-difluorinated cyclopropanes with alkenes and B(2)pin(2) for the synthesis of monofluoroalkenes

Borylative difunctionalization of alkenes has emerged as a powerful approach for synthesizing highly functionalized molecules. Herein, dual Cu/Pd-catalysed borylfluoroallylation of alkenes was smoothly achieved by using gem-difluorinated cyclopropanes and B(2)pin(2), providing the corresponding mono...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-07, Vol.57 (52), p.6400-6403
Hauptverfasser:	Suliman, Ayman M. Y., Ahmed, Ebrahim-Alkhalil M. A., Gong, Tian-Jun, Fu, Yao
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Sprache:	eng
Schlagworte:	Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
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creator	Suliman, Ayman M. Y. Ahmed, Ebrahim-Alkhalil M. A. Gong, Tian-Jun Fu, Yao
description	Borylative difunctionalization of alkenes has emerged as a powerful approach for synthesizing highly functionalized molecules. Herein, dual Cu/Pd-catalysed borylfluoroallylation of alkenes was smoothly achieved by using gem-difluorinated cyclopropanes and B(2)pin(2), providing the corresponding monofluoroalkene scaffolds in moderate to high yields with excellent stereoselectivity. Moreover, an array of synthetic building blocks can be obtained by downstream transformations.
doi_str_mv	10.1039/d1cc01620b
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subjects	Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
title	Three-component reaction of gem-difluorinated cyclopropanes with alkenes and B(2)pin(2) for the synthesis of monofluoroalkenes
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