Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism

Inflammatory bowel disease (IBD) afflicted individual and most medications have side-effects. Crataegus pinnatifida (Hawthorn), which is a safe medicine and food homolog plant, has been reported to prevent colitis in murine. Yet the bioactivity component and the underlying molecular mechanism remain...

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Veröffentlicht in:	International journal of biological macromolecules 2021-06, Vol.181, p.357-368
Hauptverfasser:	Guo, Ciliang, Wang, Yeqing, Zhang, Shihai, Zhang, Xiuqi, Du, Zhenyun, Li, Meixia, Ding, Kan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid - pharmacology Animals Anti-Inflammatory Agents - pharmacology Bacteroides - drug effects Bacteroides - growth & development Biochemistry & Molecular Biology Cell Line Chemistry Chemistry, Applied Colitis Colitis - chemically induced Colitis - drug therapy Colitis - microbiology Colitis - pathology Colon - drug effects Colon - microbiology Colon - pathology Crataegus - chemistry Crataegus pinnatifida polysaccharide Dextran Sulfate Fatty Acids, Volatile - metabolism Gastrointestinal Microbiome - drug effects Gut microbiota Inflammation - pathology Life Sciences & Biomedicine Male Metabolome Mice Mice, Inbred C57BL Models, Biological NF-kappa B - metabolism Physical Sciences Polymer Science Polysaccharides - pharmacology Polysaccharides - therapeutic use Rats Science & Technology Short chain fatty acids Signal Transduction - drug effects
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