Impact of high‐sensitivity cardiac troponin T on survival and rehospitalization after transcatheter aortic valve replacement

Background Constant elevations of the serum concentration of cardiac troponin T (TnT) indicate a myocardial injury that may affect the long‐term outcome of transcatheter aortic valve replacement (TAVR). Objectives We sought to investigate the impact of pre‐TAVR TnT on outcomes after TAVR during long‐term follow‐up. Methods In a retrospective, observational study we compared long term outcomes after TAVR between tertiles of preinterventional high‐sensitivity TnT. Systematic follow‐up was performed annually for 5 years. The primary endpoint was a composite of all‐cause death and any rehospitalization. Results Between 2010 and 2018, 2,129 patients with severe aortic valve stenosis underwent TAVR at our institution (mean age 82.6 years, 57.2% female, logistic EuroSCORE 20.5 ± 15.8). Boundaries for TnT tertiles were 42 ng/L. The median follow‐up was 895 days. Three‐year incidences for the primary endpoint were 70.9%, 76.6%, and 81.7% in the low, middle, and high tertile (log rank p