Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias

Positive allosteric modulation of metabotropic glutamate subtype 5 (mGlu5) receptor has emerged as a potential new therapeutic strategy for the treatment of schizophrenia and cognitive impairments. However, positive allosteric modulator (PAM) agonist activity has been associated with adverse side ef...

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Veröffentlicht in:	Molecular pharmacology 2021-05, Vol.99 (5), p.328-341
Hauptverfasser:	Arsova, Angela, Møller, Thor C., Hellyer, Shane D., Vedel, Line, Foster, Simon R., Hansen, Jakob L., Bräuner-Osborne, Hans, Gregory, Karen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Animals Benzamides - pharmacology Cell Line Fatty Acids - pharmacology Female HEK293 Cells Humans Life Sciences & Biomedicine MAP Kinase Signaling System - drug effects Mice Pharmacology & Pharmacy Phosphorylation - drug effects Pyrazoles - pharmacology Rats Receptor, Metabotropic Glutamate 5 - metabolism Science & Technology Signal Transduction - drug effects
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