Diversity in immunogenomics: the value and the challenge

Immunogenomics studies have been largely limited to individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations. Inclusion of a greater diversity of individuals in immunogenomics studies will substantially enhance our understa...

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Veröffentlicht in:	Nature methods 2021-06, Vol.18 (6), p.588-591
Hauptverfasser:	Peng, Kerui, Safonova, Yana, Shugay, Mikhail, Popejoy, Alice B., Rodriguez, Oscar L., Breden, Felix, Brodin, Petter, Burkhardt, Amanda M., Bustamante, Carlos, Cao-Lormeau, Van-Mai, Corcoran, Martin M., Duffy, Darragh, Fuentes-Guajardo, Macarena, Fujita, Ricardo, Greiff, Victor, Jönsson, Vanessa D., Liu, Xiao, Quintana-Murci, Lluis, Rossetti, Maura, Xie, Jianming, Yaari, Gur, Zhang, Wei, Abedalthagafi, Malak S., Adekoya, Khalid O., Ahmed, Rahaman A., Chang, Wei-Chiao, Gray, Clive, Nakamura, Yusuke, Lees, William D., Khatri, Purvesh, Alachkar, Houda, Scheepers, Cathrine, Watson, Corey T., Karlsson Hedestam, Gunilla B., Mangul, Serghei
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/250 Adaptive immunity Antigens Artificial chromosomes B-Lymphocytes - immunology Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Cloning Comment Consortia Databases, Genetic Forecasts and trends Gene loci Genealogy Genomes Genomics Germ Cells Humans Immune response Immune system Immunogenetics Immunoglobulins Immunological research Immunology Life Sciences Medicin och hälsovetenskap Peer review Population Proteomics Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology T cell receptors T-Lymphocytes - immunology Whole Genome Sequencing
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Beschreibung
Zusammenfassung:	Immunogenomics studies have been largely limited to individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations. Inclusion of a greater diversity of individuals in immunogenomics studies will substantially enhance our understanding of human immunology.
ISSN:	1548-7091 1548-7105 1548-7105
DOI:	10.1038/s41592-021-01169-5