Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus
Leptomeningeal myelomatosis (LMM) is a fatal complication that occurs in
Gespeichert in:
| Veröffentlicht in: | Neuropathology 2021-06, Vol.41 (3), p.243-249 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 249 |
|---|---|
| container_issue | 3 |
| container_start_page | 243 |
| container_title | Neuropathology |
| container_volume | 41 |
| creator | Miki, Yasuo Kamata, Kosuke Akemoto, Yui Tsushima, Fumiyasu Sakuraba, Hirotake Yamagata, Kazufumi Kurose, Akira Fukuda, Shinsaku Wakabayashi, Koichi |
| description | Leptomeningeal myelomatosis (LMM) is a fatal complication that occurs in |
| doi_str_mv | 10.1111/neup.12728 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000648927400001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2535626224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3818-c03bc395b9ed26a76ba1ffee1b8b98283a0d6d9f2afe03c52b4b6371602908d13</originalsourceid><addsrcrecordid>eNqN0U1v1DAQBmALgehSuPADUCQuVVGKPxLHPqJVC0irlgM9R44z3rqK7WDHRfvv6-0uPXBA-GD78Mzo1QxC7wm-IOV89pDnC0I7Kl6gFWkaXJNOyJdohSWRNW-b5gS9SekeY9JJKl6jE8Zkx6hgK-Q3MC_Bgbd-C2qqlB8r65eoHqDcVudJxcrtYApOLSHZVDnlrYG0lIKiK7XdRkjJPkBlQnRVMJUOzmVvtXoyd7sxBg3znZpyeoteGTUleHd8T9Ht1eXP9bd6c_P1-_rLptZMEFFrzAbNZDtIGClXHR8UMQaADGKQogRXeOSjNFQZwEy3dGgGzjrCMZVYjISdorND3zmGX7mk7Z1NGqZJeQg59bSlLW-Z6Pb041_0PuToS7qiWMspp7Qp6vygdAwpRTD9HK1TcdcT3O-30O-30D9toeAPx5Z5cDA-0z9jL-DTAfyGIZikLXgNzwxjzBshadeUH94nFP-v13Ypcw9-HbJfSik5ltoJdv_I3F9f3v44pH8EHoq1sA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2535626224</pqid></control><display><type>article</type><title>Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus</title><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Miki, Yasuo ; Kamata, Kosuke ; Akemoto, Yui ; Tsushima, Fumiyasu ; Sakuraba, Hirotake ; Yamagata, Kazufumi ; Kurose, Akira ; Fukuda, Shinsaku ; Wakabayashi, Koichi</creator><creatorcontrib>Miki, Yasuo ; Kamata, Kosuke ; Akemoto, Yui ; Tsushima, Fumiyasu ; Sakuraba, Hirotake ; Yamagata, Kazufumi ; Kurose, Akira ; Fukuda, Shinsaku ; Wakabayashi, Koichi</creatorcontrib><description>Leptomeningeal myelomatosis (LMM) is a fatal complication that occurs in < 1% of patients with multiple myeloma. Many patients with LMM present with neurologic symptoms referable to cranial neuropathies, while the manifestation of communicating hydrocephalus has been underrecognized. A Japanese man with Bence Jones protein‐κ multiple myeloma developed fever and headache at age 54 years. He then became somnolent and went into a coma. Neuroimaging analyses identified rapidly progressive communicating hydrocephalus due to meningitis. He died 83 days after the onset of headache without any response to treatment at age 55 years. No symptoms or signs associated with cranial nerves were found during the course of illness. Postmortem examination revealed hydrocephalus and diffuse infiltration of myeloma cells into the subarachnoid space of the cerebrum, cerebellum, and brainstem. In addition, the interstitial tissue of the choroid plexuses was filled with myeloma cells. These myeloma cells were positive for CD156 and light chain κ. The Ki‐67 labeling index in myeloma cells of the central nervous system (CNS) was 30–40%. Histopathological examination further revealed many myeloma cells on the surface of the lateral, third and fourth ventricles and at the area postrema of the medulla oblongata. Patients with LMM can develop an aggressive form of communicating hydrocephalus. Given that cerebrospinal fluid, produced by epithelial cells in the choroid plexuses of the ventricles, passes into the subarachnoid space through the third and fourth ventricles, myeloma cells may invade the CNS through the choroid plexuses.</description><identifier>ISSN: 0919-6544</identifier><identifier>EISSN: 1440-1789</identifier><identifier>DOI: 10.1111/neup.12728</identifier><identifier>PMID: 33973283</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Area postrema ; Brain stem ; Central nervous system ; Cerebellum ; Cerebrospinal fluid ; Cerebrum ; Clinical Neurology ; CNS invasion ; CNS relapse ; communicating hydrocephalus ; Cranial nerves ; Epithelial cells ; Fever ; Headache ; Hydrocephalus ; leptomeningeal myelomatosis ; Life Sciences & Biomedicine ; Medulla oblongata ; Meninges ; Meningitis ; Multiple myeloma ; Neuroimaging ; Neuropathy ; Neurosciences ; Neurosciences & Neurology ; Pathology ; Science & Technology ; Skull ; Subarachnoid space</subject><ispartof>Neuropathology, 2021-06, Vol.41 (3), p.243-249</ispartof><rights>2021 Japanese Society of Neuropathology</rights><rights>2021 Japanese Society of Neuropathology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000648927400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3818-c03bc395b9ed26a76ba1ffee1b8b98283a0d6d9f2afe03c52b4b6371602908d13</citedby><cites>FETCH-LOGICAL-c3818-c03bc395b9ed26a76ba1ffee1b8b98283a0d6d9f2afe03c52b4b6371602908d13</cites><orcidid>0000-0001-9375-9590 ; 0000-0002-3756-7209</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fneup.12728$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fneup.12728$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,39263,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33973283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miki, Yasuo</creatorcontrib><creatorcontrib>Kamata, Kosuke</creatorcontrib><creatorcontrib>Akemoto, Yui</creatorcontrib><creatorcontrib>Tsushima, Fumiyasu</creatorcontrib><creatorcontrib>Sakuraba, Hirotake</creatorcontrib><creatorcontrib>Yamagata, Kazufumi</creatorcontrib><creatorcontrib>Kurose, Akira</creatorcontrib><creatorcontrib>Fukuda, Shinsaku</creatorcontrib><creatorcontrib>Wakabayashi, Koichi</creatorcontrib><title>Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus</title><title>Neuropathology</title><addtitle>NEUROPATHOLOGY</addtitle><addtitle>Neuropathology</addtitle><description>Leptomeningeal myelomatosis (LMM) is a fatal complication that occurs in < 1% of patients with multiple myeloma. Many patients with LMM present with neurologic symptoms referable to cranial neuropathies, while the manifestation of communicating hydrocephalus has been underrecognized. A Japanese man with Bence Jones protein‐κ multiple myeloma developed fever and headache at age 54 years. He then became somnolent and went into a coma. Neuroimaging analyses identified rapidly progressive communicating hydrocephalus due to meningitis. He died 83 days after the onset of headache without any response to treatment at age 55 years. No symptoms or signs associated with cranial nerves were found during the course of illness. Postmortem examination revealed hydrocephalus and diffuse infiltration of myeloma cells into the subarachnoid space of the cerebrum, cerebellum, and brainstem. In addition, the interstitial tissue of the choroid plexuses was filled with myeloma cells. These myeloma cells were positive for CD156 and light chain κ. The Ki‐67 labeling index in myeloma cells of the central nervous system (CNS) was 30–40%. Histopathological examination further revealed many myeloma cells on the surface of the lateral, third and fourth ventricles and at the area postrema of the medulla oblongata. Patients with LMM can develop an aggressive form of communicating hydrocephalus. Given that cerebrospinal fluid, produced by epithelial cells in the choroid plexuses of the ventricles, passes into the subarachnoid space through the third and fourth ventricles, myeloma cells may invade the CNS through the choroid plexuses.</description><subject>Area postrema</subject><subject>Brain stem</subject><subject>Central nervous system</subject><subject>Cerebellum</subject><subject>Cerebrospinal fluid</subject><subject>Cerebrum</subject><subject>Clinical Neurology</subject><subject>CNS invasion</subject><subject>CNS relapse</subject><subject>communicating hydrocephalus</subject><subject>Cranial nerves</subject><subject>Epithelial cells</subject><subject>Fever</subject><subject>Headache</subject><subject>Hydrocephalus</subject><subject>leptomeningeal myelomatosis</subject><subject>Life Sciences & Biomedicine</subject><subject>Medulla oblongata</subject><subject>Meninges</subject><subject>Meningitis</subject><subject>Multiple myeloma</subject><subject>Neuroimaging</subject><subject>Neuropathy</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Pathology</subject><subject>Science & Technology</subject><subject>Skull</subject><subject>Subarachnoid space</subject><issn>0919-6544</issn><issn>1440-1789</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqN0U1v1DAQBmALgehSuPADUCQuVVGKPxLHPqJVC0irlgM9R44z3rqK7WDHRfvv6-0uPXBA-GD78Mzo1QxC7wm-IOV89pDnC0I7Kl6gFWkaXJNOyJdohSWRNW-b5gS9SekeY9JJKl6jE8Zkx6hgK-Q3MC_Bgbd-C2qqlB8r65eoHqDcVudJxcrtYApOLSHZVDnlrYG0lIKiK7XdRkjJPkBlQnRVMJUOzmVvtXoyd7sxBg3znZpyeoteGTUleHd8T9Ht1eXP9bd6c_P1-_rLptZMEFFrzAbNZDtIGClXHR8UMQaADGKQogRXeOSjNFQZwEy3dGgGzjrCMZVYjISdorND3zmGX7mk7Z1NGqZJeQg59bSlLW-Z6Pb041_0PuToS7qiWMspp7Qp6vygdAwpRTD9HK1TcdcT3O-30O-30D9toeAPx5Z5cDA-0z9jL-DTAfyGIZikLXgNzwxjzBshadeUH94nFP-v13Ypcw9-HbJfSik5ltoJdv_I3F9f3v44pH8EHoq1sA</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Miki, Yasuo</creator><creator>Kamata, Kosuke</creator><creator>Akemoto, Yui</creator><creator>Tsushima, Fumiyasu</creator><creator>Sakuraba, Hirotake</creator><creator>Yamagata, Kazufumi</creator><creator>Kurose, Akira</creator><creator>Fukuda, Shinsaku</creator><creator>Wakabayashi, Koichi</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9375-9590</orcidid><orcidid>https://orcid.org/0000-0002-3756-7209</orcidid></search><sort><creationdate>202106</creationdate><title>Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus</title><author>Miki, Yasuo ; Kamata, Kosuke ; Akemoto, Yui ; Tsushima, Fumiyasu ; Sakuraba, Hirotake ; Yamagata, Kazufumi ; Kurose, Akira ; Fukuda, Shinsaku ; Wakabayashi, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3818-c03bc395b9ed26a76ba1ffee1b8b98283a0d6d9f2afe03c52b4b6371602908d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Area postrema</topic><topic>Brain stem</topic><topic>Central nervous system</topic><topic>Cerebellum</topic><topic>Cerebrospinal fluid</topic><topic>Cerebrum</topic><topic>Clinical Neurology</topic><topic>CNS invasion</topic><topic>CNS relapse</topic><topic>communicating hydrocephalus</topic><topic>Cranial nerves</topic><topic>Epithelial cells</topic><topic>Fever</topic><topic>Headache</topic><topic>Hydrocephalus</topic><topic>leptomeningeal myelomatosis</topic><topic>Life Sciences & Biomedicine</topic><topic>Medulla oblongata</topic><topic>Meninges</topic><topic>Meningitis</topic><topic>Multiple myeloma</topic><topic>Neuroimaging</topic><topic>Neuropathy</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Pathology</topic><topic>Science & Technology</topic><topic>Skull</topic><topic>Subarachnoid space</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miki, Yasuo</creatorcontrib><creatorcontrib>Kamata, Kosuke</creatorcontrib><creatorcontrib>Akemoto, Yui</creatorcontrib><creatorcontrib>Tsushima, Fumiyasu</creatorcontrib><creatorcontrib>Sakuraba, Hirotake</creatorcontrib><creatorcontrib>Yamagata, Kazufumi</creatorcontrib><creatorcontrib>Kurose, Akira</creatorcontrib><creatorcontrib>Fukuda, Shinsaku</creatorcontrib><creatorcontrib>Wakabayashi, Koichi</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miki, Yasuo</au><au>Kamata, Kosuke</au><au>Akemoto, Yui</au><au>Tsushima, Fumiyasu</au><au>Sakuraba, Hirotake</au><au>Yamagata, Kazufumi</au><au>Kurose, Akira</au><au>Fukuda, Shinsaku</au><au>Wakabayashi, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus</atitle><jtitle>Neuropathology</jtitle><stitle>NEUROPATHOLOGY</stitle><addtitle>Neuropathology</addtitle><date>2021-06</date><risdate>2021</risdate><volume>41</volume><issue>3</issue><spage>243</spage><epage>249</epage><pages>243-249</pages><issn>0919-6544</issn><eissn>1440-1789</eissn><abstract>Leptomeningeal myelomatosis (LMM) is a fatal complication that occurs in < 1% of patients with multiple myeloma. Many patients with LMM present with neurologic symptoms referable to cranial neuropathies, while the manifestation of communicating hydrocephalus has been underrecognized. A Japanese man with Bence Jones protein‐κ multiple myeloma developed fever and headache at age 54 years. He then became somnolent and went into a coma. Neuroimaging analyses identified rapidly progressive communicating hydrocephalus due to meningitis. He died 83 days after the onset of headache without any response to treatment at age 55 years. No symptoms or signs associated with cranial nerves were found during the course of illness. Postmortem examination revealed hydrocephalus and diffuse infiltration of myeloma cells into the subarachnoid space of the cerebrum, cerebellum, and brainstem. In addition, the interstitial tissue of the choroid plexuses was filled with myeloma cells. These myeloma cells were positive for CD156 and light chain κ. The Ki‐67 labeling index in myeloma cells of the central nervous system (CNS) was 30–40%. Histopathological examination further revealed many myeloma cells on the surface of the lateral, third and fourth ventricles and at the area postrema of the medulla oblongata. Patients with LMM can develop an aggressive form of communicating hydrocephalus. Given that cerebrospinal fluid, produced by epithelial cells in the choroid plexuses of the ventricles, passes into the subarachnoid space through the third and fourth ventricles, myeloma cells may invade the CNS through the choroid plexuses.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>33973283</pmid><doi>10.1111/neup.12728</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9375-9590</orcidid><orcidid>https://orcid.org/0000-0002-3756-7209</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-6544 |
| ispartof | Neuropathology, 2021-06, Vol.41 (3), p.243-249 |
| issn | 0919-6544 1440-1789 |
| language | eng |
| recordid | cdi_webofscience_primary_000648927400001 |
| source | Access via Wiley Online Library; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Area postrema Brain stem Central nervous system Cerebellum Cerebrospinal fluid Cerebrum Clinical Neurology CNS invasion CNS relapse communicating hydrocephalus Cranial nerves Epithelial cells Fever Headache Hydrocephalus leptomeningeal myelomatosis Life Sciences & Biomedicine Medulla oblongata Meninges Meningitis Multiple myeloma Neuroimaging Neuropathy Neurosciences Neurosciences & Neurology Pathology Science & Technology Skull Subarachnoid space |
| title | Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T21%3A43%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptomeningeal%20and%20intraventricular%20myelomatosis%20manifesting%20an%20aggressive%20form%20of%20communicating%20hydrocephalus&rft.jtitle=Neuropathology&rft.au=Miki,%20Yasuo&rft.date=2021-06&rft.volume=41&rft.issue=3&rft.spage=243&rft.epage=249&rft.pages=243-249&rft.issn=0919-6544&rft.eissn=1440-1789&rft_id=info:doi/10.1111/neup.12728&rft_dat=%3Cproquest_webof%3E2535626224%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2535626224&rft_id=info:pmid/33973283&rfr_iscdi=true |