Ring closure strategy leads to potent RIPK3 inhibitors

Necroptosis is a form of regulated necrotic cell death that is independent of caspases. Receptor-interacting protein kinase 3 (RIPK3) has been identified as a key regulator for necroptosis, and has been proposed as a potential therapeutic target for the treatment of diseases associated with necropto...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-05, Vol.217, p.113327-113327, Article 113327
Hauptverfasser:	Wu, Shuwei, Xu, Chen, Xia, Kaijiang, Lin, Yu, Tian, Sheng, Ma, Haikuo, Ji, Yuting, Zhu, Fang, He, Sudan, Zhang, Xiaohu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell death Chemistry, Medicinal Inflammation Kinase Life Sciences & Biomedicine Necroptosis Pharmacology & Pharmacy RIPK1 RIPK3 Science & Technology
Online-Zugang:	Volltext
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