Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets

Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets

Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These multiprotein structures contain, among other components, the cyclin-dependent kinases 8 and 19. These and other transcriptional protein kinases are re...

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Veröffentlicht in:Actanaturae 2021-01, Vol.13 (1), p.4-15
Hauptverfasser: Bruter, A. V., Rodionova, M. D., Varlamova, E. A., Shtil, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry & Molecular Biology
Cell Biology
Life Sciences & Biomedicine
Science & Technology
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Zusammenfassung:Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These multiprotein structures contain, among other components, the cyclin-dependent kinases 8 and 19. These and other transcriptional protein kinases are regarded as novel targets for pharmacological inhibition by antitumor drug candidates.
ISSN:2075-8251
DOI:10.32607/actanaturae.11067