Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs
Abstract Background Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant p...
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| Veröffentlicht in: | Journal of the Pediatric Infectious Diseases Society 2021-04, Vol.10 (3), p.230-236 |
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| creator | Chu, Helen Y Newman, Kira L Englund, Janet A Cho, Shari Bull, Catherine Lacombe, Kirsten Carlin, Kristen Bulkow, Lisa R Rudolph, Karen DeByle, Carolynn Berner, James Klejka, Joseph Singleton, Rosalyn |
| description | Abstract
Background
Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has not previously been evaluated in the AN population.
Methods
Serum samples collected during pregnancy and at birth from AN mother–infant pairs in the Yukon-Kuskokwim Delta region (YKD) of Alaska (2000–2011; n = 75) and predominantly white pairs in Seattle, Washington (2014–2016; n = 57), were tested for RSV and influenza antibody using a microneutralization and hemagglutination inhibition assay, respectively, and compared between sites.
Results
Mean RSV antibody concentrations in pregnant women in YKD and Seattle were similar (log2 RSV antibody 10.6 vs 10.7, P = .86), but cord blood RSV antibody concentrations were significantly lower in infants born to mothers in YKD compared with Seattle (log2 RSV antibody 11.0 vs 12.2, P < .001). Maternal and cord blood influenza antibody concentrations were lower for women and infants in YKD compared with Seattle for all 4 influenza antigens tested (all P < .05). The mean cord to maternal RSV antibody transfer ratio was 1.15 (standard deviation [SD], 0.13) in mother–infant pairs in Seattle compared with 1.04 (SD, 0.08) in YKD. Mean cord blood to maternal antibody transfer ratios for influenza antigens ranged from 1.22 to 1.42 in Seattle and from 1.05 to 1.59 in YKD.
Conclusions
Though the transplacental antibody transfer ratio was high (>1.0) for both groups, transfer ratios for RSV antibody were significantly lower in AN mother–infant pairs. Further studies are needed to elucidate the impact of lower transplacental antibody transfer on infant disease risk in rural Alaska.
Alaska Native and continental US mother-infant pairs have high transplacental antibody transfer ratios (>1.0) for influenza and respiratory syncytial virus, but anti-respiratory syncytial virus antibody levels are significantly lower in Alaska Native pairs than in those from the continental US.
Similar RSV antibody levels in Alaska-native (AN) and non-AN women
AN infants’ cord blood RSV antibody levels lower
Maternal and cord blood influenza antibody levels lower in AN women and infants
AN mother–infant pairs’ RSV antibody transfer ratios significantly lower |
| doi_str_mv | 10.1093/jpids/piaa040 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000642325300002CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jpids/piaa040</oup_id><sourcerecordid>2398612883</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-156be3131e32bee06b5b19917a546d3f84ec061479c83bd65f193b8857347d713</originalsourceid><addsrcrecordid>eNqNkctu1TAQhiMEolXpki3yEgmF-pbE2SAdHXGpVC6iha01SSbUJcdObacorJB4BN6QJ8Hn0gOswBtb429-z-8_yx4y-pTRWpxcjaYLJ6MBoJLeyQ45lSqvOK3u3p5ZLQ6y4xCuaFplwQol72cHgouyZhU_zL5feLBhHKBFG2Eg7zGMxkN0fibns23naFL1o_FTIGA7cmr7YUL7FXa1hY2mcd1MNjo9emIsWQwQPgN5A9Hc4KbtHCHGAclrFy_R__z2I-mAjeQdGB8eZPd6GAIe7_aj7MOL5xfLV_nZ25eny8VZ3kpOY86KskHBBEPBG0RaNkXD6mQDCll2olcSW1oyWdWtEk1XFn0y3yhVVEJWXcXEUfZsqztOzQq7tWMPgx69WYGftQOj_76x5lJ_cjdaUS4Ek0ng8U7Au-sJQ9QrE1ocBrDopqC5qFXJuFIiofkWbb0LwWO_f4ZRvc5Ob7LTu-wS_-jP2fb0bVIJUFvgCzauD61B2-IeW4crueCFWOfMlyamv3d26SYbU-uT_2_9bdJN4z-G_gUbEsja</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2398612883</pqid></control><display><type>article</type><title>Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Alma/SFX Local Collection</source><creator>Chu, Helen Y ; Newman, Kira L ; Englund, Janet A ; Cho, Shari ; Bull, Catherine ; Lacombe, Kirsten ; Carlin, Kristen ; Bulkow, Lisa R ; Rudolph, Karen ; DeByle, Carolynn ; Berner, James ; Klejka, Joseph ; Singleton, Rosalyn</creator><creatorcontrib>Chu, Helen Y ; Newman, Kira L ; Englund, Janet A ; Cho, Shari ; Bull, Catherine ; Lacombe, Kirsten ; Carlin, Kristen ; Bulkow, Lisa R ; Rudolph, Karen ; DeByle, Carolynn ; Berner, James ; Klejka, Joseph ; Singleton, Rosalyn</creatorcontrib><description>Abstract
Background
Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has not previously been evaluated in the AN population.
Methods
Serum samples collected during pregnancy and at birth from AN mother–infant pairs in the Yukon-Kuskokwim Delta region (YKD) of Alaska (2000–2011; n = 75) and predominantly white pairs in Seattle, Washington (2014–2016; n = 57), were tested for RSV and influenza antibody using a microneutralization and hemagglutination inhibition assay, respectively, and compared between sites.
Results
Mean RSV antibody concentrations in pregnant women in YKD and Seattle were similar (log2 RSV antibody 10.6 vs 10.7, P = .86), but cord blood RSV antibody concentrations were significantly lower in infants born to mothers in YKD compared with Seattle (log2 RSV antibody 11.0 vs 12.2, P < .001). Maternal and cord blood influenza antibody concentrations were lower for women and infants in YKD compared with Seattle for all 4 influenza antigens tested (all P < .05). The mean cord to maternal RSV antibody transfer ratio was 1.15 (standard deviation [SD], 0.13) in mother–infant pairs in Seattle compared with 1.04 (SD, 0.08) in YKD. Mean cord blood to maternal antibody transfer ratios for influenza antigens ranged from 1.22 to 1.42 in Seattle and from 1.05 to 1.59 in YKD.
Conclusions
Though the transplacental antibody transfer ratio was high (>1.0) for both groups, transfer ratios for RSV antibody were significantly lower in AN mother–infant pairs. Further studies are needed to elucidate the impact of lower transplacental antibody transfer on infant disease risk in rural Alaska.
Alaska Native and continental US mother-infant pairs have high transplacental antibody transfer ratios (>1.0) for influenza and respiratory syncytial virus, but anti-respiratory syncytial virus antibody levels are significantly lower in Alaska Native pairs than in those from the continental US.
Similar RSV antibody levels in Alaska-native (AN) and non-AN women
AN infants’ cord blood RSV antibody levels lower
Maternal and cord blood influenza antibody levels lower in AN women and infants
AN mother–infant pairs’ RSV antibody transfer ratios significantly lower</description><identifier>ISSN: 2048-7193</identifier><identifier>ISSN: 2048-7207</identifier><identifier>EISSN: 2048-7207</identifier><identifier>DOI: 10.1093/jpids/piaa040</identifier><identifier>PMID: 32369172</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Alaska Natives ; Antibodies, Viral ; Female ; Humans ; Infant ; Infant, Newborn ; Infectious Diseases ; Life Sciences & Biomedicine ; Mothers ; Original ; Orthomyxoviridae ; Pediatrics ; Pregnancy ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human ; Science & Technology</subject><ispartof>Journal of the Pediatric Infectious Diseases Society, 2021-04, Vol.10 (3), p.230-236</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000642325300002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c420t-156be3131e32bee06b5b19917a546d3f84ec061479c83bd65f193b8857347d713</citedby><cites>FETCH-LOGICAL-c420t-156be3131e32bee06b5b19917a546d3f84ec061479c83bd65f193b8857347d713</cites><orcidid>0000-0002-8279-1111</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,1585,27929,27930,39263</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32369172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chu, Helen Y</creatorcontrib><creatorcontrib>Newman, Kira L</creatorcontrib><creatorcontrib>Englund, Janet A</creatorcontrib><creatorcontrib>Cho, Shari</creatorcontrib><creatorcontrib>Bull, Catherine</creatorcontrib><creatorcontrib>Lacombe, Kirsten</creatorcontrib><creatorcontrib>Carlin, Kristen</creatorcontrib><creatorcontrib>Bulkow, Lisa R</creatorcontrib><creatorcontrib>Rudolph, Karen</creatorcontrib><creatorcontrib>DeByle, Carolynn</creatorcontrib><creatorcontrib>Berner, James</creatorcontrib><creatorcontrib>Klejka, Joseph</creatorcontrib><creatorcontrib>Singleton, Rosalyn</creatorcontrib><title>Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs</title><title>Journal of the Pediatric Infectious Diseases Society</title><addtitle>J PEDIAT INF DIS SOC</addtitle><addtitle>J Pediatric Infect Dis Soc</addtitle><description>Abstract
Background
Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has not previously been evaluated in the AN population.
Methods
Serum samples collected during pregnancy and at birth from AN mother–infant pairs in the Yukon-Kuskokwim Delta region (YKD) of Alaska (2000–2011; n = 75) and predominantly white pairs in Seattle, Washington (2014–2016; n = 57), were tested for RSV and influenza antibody using a microneutralization and hemagglutination inhibition assay, respectively, and compared between sites.
Results
Mean RSV antibody concentrations in pregnant women in YKD and Seattle were similar (log2 RSV antibody 10.6 vs 10.7, P = .86), but cord blood RSV antibody concentrations were significantly lower in infants born to mothers in YKD compared with Seattle (log2 RSV antibody 11.0 vs 12.2, P < .001). Maternal and cord blood influenza antibody concentrations were lower for women and infants in YKD compared with Seattle for all 4 influenza antigens tested (all P < .05). The mean cord to maternal RSV antibody transfer ratio was 1.15 (standard deviation [SD], 0.13) in mother–infant pairs in Seattle compared with 1.04 (SD, 0.08) in YKD. Mean cord blood to maternal antibody transfer ratios for influenza antigens ranged from 1.22 to 1.42 in Seattle and from 1.05 to 1.59 in YKD.
Conclusions
Though the transplacental antibody transfer ratio was high (>1.0) for both groups, transfer ratios for RSV antibody were significantly lower in AN mother–infant pairs. Further studies are needed to elucidate the impact of lower transplacental antibody transfer on infant disease risk in rural Alaska.
Alaska Native and continental US mother-infant pairs have high transplacental antibody transfer ratios (>1.0) for influenza and respiratory syncytial virus, but anti-respiratory syncytial virus antibody levels are significantly lower in Alaska Native pairs than in those from the continental US.
Similar RSV antibody levels in Alaska-native (AN) and non-AN women
AN infants’ cord blood RSV antibody levels lower
Maternal and cord blood influenza antibody levels lower in AN women and infants
AN mother–infant pairs’ RSV antibody transfer ratios significantly lower</description><subject>Alaska Natives</subject><subject>Antibodies, Viral</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious Diseases</subject><subject>Life Sciences & Biomedicine</subject><subject>Mothers</subject><subject>Original</subject><subject>Orthomyxoviridae</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Respiratory Syncytial Virus Infections</subject><subject>Respiratory Syncytial Virus, Human</subject><subject>Science & Technology</subject><issn>2048-7193</issn><issn>2048-7207</issn><issn>2048-7207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkctu1TAQhiMEolXpki3yEgmF-pbE2SAdHXGpVC6iha01SSbUJcdObacorJB4BN6QJ8Hn0gOswBtb429-z-8_yx4y-pTRWpxcjaYLJ6MBoJLeyQ45lSqvOK3u3p5ZLQ6y4xCuaFplwQol72cHgouyZhU_zL5feLBhHKBFG2Eg7zGMxkN0fibns23naFL1o_FTIGA7cmr7YUL7FXa1hY2mcd1MNjo9emIsWQwQPgN5A9Hc4KbtHCHGAclrFy_R__z2I-mAjeQdGB8eZPd6GAIe7_aj7MOL5xfLV_nZ25eny8VZ3kpOY86KskHBBEPBG0RaNkXD6mQDCll2olcSW1oyWdWtEk1XFn0y3yhVVEJWXcXEUfZsqztOzQq7tWMPgx69WYGftQOj_76x5lJ_cjdaUS4Ek0ng8U7Au-sJQ9QrE1ocBrDopqC5qFXJuFIiofkWbb0LwWO_f4ZRvc5Ob7LTu-wS_-jP2fb0bVIJUFvgCzauD61B2-IeW4crueCFWOfMlyamv3d26SYbU-uT_2_9bdJN4z-G_gUbEsja</recordid><startdate>20210403</startdate><enddate>20210403</enddate><creator>Chu, Helen Y</creator><creator>Newman, Kira L</creator><creator>Englund, Janet A</creator><creator>Cho, Shari</creator><creator>Bull, Catherine</creator><creator>Lacombe, Kirsten</creator><creator>Carlin, Kristen</creator><creator>Bulkow, Lisa R</creator><creator>Rudolph, Karen</creator><creator>DeByle, Carolynn</creator><creator>Berner, James</creator><creator>Klejka, Joseph</creator><creator>Singleton, Rosalyn</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8279-1111</orcidid></search><sort><creationdate>20210403</creationdate><title>Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs</title><author>Chu, Helen Y ; Newman, Kira L ; Englund, Janet A ; Cho, Shari ; Bull, Catherine ; Lacombe, Kirsten ; Carlin, Kristen ; Bulkow, Lisa R ; Rudolph, Karen ; DeByle, Carolynn ; Berner, James ; Klejka, Joseph ; Singleton, Rosalyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-156be3131e32bee06b5b19917a546d3f84ec061479c83bd65f193b8857347d713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alaska Natives</topic><topic>Antibodies, Viral</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious Diseases</topic><topic>Life Sciences & Biomedicine</topic><topic>Mothers</topic><topic>Original</topic><topic>Orthomyxoviridae</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Respiratory Syncytial Virus Infections</topic><topic>Respiratory Syncytial Virus, Human</topic><topic>Science & Technology</topic><toplevel>online_resources</toplevel><creatorcontrib>Chu, Helen Y</creatorcontrib><creatorcontrib>Newman, Kira L</creatorcontrib><creatorcontrib>Englund, Janet A</creatorcontrib><creatorcontrib>Cho, Shari</creatorcontrib><creatorcontrib>Bull, Catherine</creatorcontrib><creatorcontrib>Lacombe, Kirsten</creatorcontrib><creatorcontrib>Carlin, Kristen</creatorcontrib><creatorcontrib>Bulkow, Lisa R</creatorcontrib><creatorcontrib>Rudolph, Karen</creatorcontrib><creatorcontrib>DeByle, Carolynn</creatorcontrib><creatorcontrib>Berner, James</creatorcontrib><creatorcontrib>Klejka, Joseph</creatorcontrib><creatorcontrib>Singleton, Rosalyn</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Pediatric Infectious Diseases Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chu, Helen Y</au><au>Newman, Kira L</au><au>Englund, Janet A</au><au>Cho, Shari</au><au>Bull, Catherine</au><au>Lacombe, Kirsten</au><au>Carlin, Kristen</au><au>Bulkow, Lisa R</au><au>Rudolph, Karen</au><au>DeByle, Carolynn</au><au>Berner, James</au><au>Klejka, Joseph</au><au>Singleton, Rosalyn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs</atitle><jtitle>Journal of the Pediatric Infectious Diseases Society</jtitle><stitle>J PEDIAT INF DIS SOC</stitle><addtitle>J Pediatric Infect Dis Soc</addtitle><date>2021-04-03</date><risdate>2021</risdate><volume>10</volume><issue>3</issue><spage>230</spage><epage>236</epage><pages>230-236</pages><issn>2048-7193</issn><issn>2048-7207</issn><eissn>2048-7207</eissn><abstract>Abstract
Background
Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has not previously been evaluated in the AN population.
Methods
Serum samples collected during pregnancy and at birth from AN mother–infant pairs in the Yukon-Kuskokwim Delta region (YKD) of Alaska (2000–2011; n = 75) and predominantly white pairs in Seattle, Washington (2014–2016; n = 57), were tested for RSV and influenza antibody using a microneutralization and hemagglutination inhibition assay, respectively, and compared between sites.
Results
Mean RSV antibody concentrations in pregnant women in YKD and Seattle were similar (log2 RSV antibody 10.6 vs 10.7, P = .86), but cord blood RSV antibody concentrations were significantly lower in infants born to mothers in YKD compared with Seattle (log2 RSV antibody 11.0 vs 12.2, P < .001). Maternal and cord blood influenza antibody concentrations were lower for women and infants in YKD compared with Seattle for all 4 influenza antigens tested (all P < .05). The mean cord to maternal RSV antibody transfer ratio was 1.15 (standard deviation [SD], 0.13) in mother–infant pairs in Seattle compared with 1.04 (SD, 0.08) in YKD. Mean cord blood to maternal antibody transfer ratios for influenza antigens ranged from 1.22 to 1.42 in Seattle and from 1.05 to 1.59 in YKD.
Conclusions
Though the transplacental antibody transfer ratio was high (>1.0) for both groups, transfer ratios for RSV antibody were significantly lower in AN mother–infant pairs. Further studies are needed to elucidate the impact of lower transplacental antibody transfer on infant disease risk in rural Alaska.
Alaska Native and continental US mother-infant pairs have high transplacental antibody transfer ratios (>1.0) for influenza and respiratory syncytial virus, but anti-respiratory syncytial virus antibody levels are significantly lower in Alaska Native pairs than in those from the continental US.
Similar RSV antibody levels in Alaska-native (AN) and non-AN women
AN infants’ cord blood RSV antibody levels lower
Maternal and cord blood influenza antibody levels lower in AN women and infants
AN mother–infant pairs’ RSV antibody transfer ratios significantly lower</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32369172</pmid><doi>10.1093/jpids/piaa040</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8279-1111</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alaska Natives Antibodies, Viral Female Humans Infant Infant, Newborn Infectious Diseases Life Sciences & Biomedicine Mothers Original Orthomyxoviridae Pediatrics Pregnancy Respiratory Syncytial Virus Infections Respiratory Syncytial Virus, Human Science & Technology |
| title | Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs |
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