Effects of dietary supplementation with the antimicrobial peptide WK3 on growth performance and intestinal health in diarrheic weanling piglets

This study aimed to determine the effects of the antimicrobial peptide WK3, as an alternative to antibiotics, on diarrheic piglets. Before treatment, all pigs were orally challenged with 10 8  CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatme...

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Veröffentlicht in:Journal of Applied Animal Research 2021-01, Vol.49 (1), p.147-153
Hauptverfasser: Cao, Chunyu, Li, Jianan, Ma, Qiuyuan, Zhang, Licong, Shan, Anshan
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Li, Jianan
Ma, Qiuyuan
Zhang, Licong
Shan, Anshan
description This study aimed to determine the effects of the antimicrobial peptide WK3, as an alternative to antibiotics, on diarrheic piglets. Before treatment, all pigs were orally challenged with 10 8  CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatments of eight piglets each, namely, the control treatment, antibiotic treatment and antimicrobial peptide treatment. The experimental results show that the addition of the antibacterial peptide WK3 to the diet can significantly reduce the chance of diarrhea. Compared with the CON group, average daily gain (ADG) and average daily feed intake (ADFI) of the WK3 group (P 
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Before treatment, all pigs were orally challenged with 10 8  CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatments of eight piglets each, namely, the control treatment, antibiotic treatment and antimicrobial peptide treatment. The experimental results show that the addition of the antibacterial peptide WK3 to the diet can significantly reduce the chance of diarrhea. Compared with the CON group, average daily gain (ADG) and average daily feed intake (ADFI) of the WK3 group (P < 0.05) increased. Compared with that with the control treatment and antibiotic treatment, the level of GSH-Px in the jejunum significantly increased (P < 0.05) with WK3 supplementation. The numbers of bacteria, Lactobacillus spp. (P < 0.01) and Bifidobacteria spp. (P < 0.01), were higher in the WK3 group, but Enterobacterium spp. in digesta of the cecum were depleted (P < 0.01). The WK3 group decreased the expression levels of the inflammatory factors IL-1α (P < 0.05) and TLR-4 (P < 0.01) in the jejunal mucosa contrast to the control treatment.]]></description><identifier>ISSN: 0971-2119</identifier><identifier>EISSN: 0974-1844</identifier><identifier>DOI: 10.1080/09712119.2021.1916507</identifier><language>eng</language><publisher>ABINGDON: Taylor &amp; Francis</publisher><subject>Agriculture ; Agriculture, Dairy &amp; Animal Science ; Antibiotics ; Antimicrobial peptide ; Antimicrobial peptides ; Cecum ; Diarrhea ; diarrhea incidence ; Feed additives ; growth performance ; Inflammation ; intestinal inflammation ; Jejunum ; Life Sciences &amp; Biomedicine ; Mucosa ; Peptides ; Physical growth ; Science &amp; Technology ; weaned piglets ; WK3</subject><ispartof>Journal of Applied Animal Research, 2021-01, Vol.49 (1), p.147-153</ispartof><rights>2021 The Author(s). 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Before treatment, all pigs were orally challenged with 10 8  CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatments of eight piglets each, namely, the control treatment, antibiotic treatment and antimicrobial peptide treatment. The experimental results show that the addition of the antibacterial peptide WK3 to the diet can significantly reduce the chance of diarrhea. Compared with the CON group, average daily gain (ADG) and average daily feed intake (ADFI) of the WK3 group (P < 0.05) increased. Compared with that with the control treatment and antibiotic treatment, the level of GSH-Px in the jejunum significantly increased (P < 0.05) with WK3 supplementation. The numbers of bacteria, Lactobacillus spp. (P < 0.01) and Bifidobacteria spp. (P < 0.01), were higher in the WK3 group, but Enterobacterium spp. in digesta of the cecum were depleted (P < 0.01). The WK3 group decreased the expression levels of the inflammatory factors IL-1α (P < 0.05) and TLR-4 (P < 0.01) in the jejunal mucosa contrast to the control treatment.]]></abstract><cop>ABINGDON</cop><pub>Taylor &amp; Francis</pub><doi>10.1080/09712119.2021.1916507</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2830-7509</orcidid><oa>free_for_read</oa></addata></record>
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subjects Agriculture
Agriculture, Dairy & Animal Science
Antibiotics
Antimicrobial peptide
Antimicrobial peptides
Cecum
Diarrhea
diarrhea incidence
Feed additives
growth performance
Inflammation
intestinal inflammation
Jejunum
Life Sciences & Biomedicine
Mucosa
Peptides
Physical growth
Science & Technology
weaned piglets
WK3
title Effects of dietary supplementation with the antimicrobial peptide WK3 on growth performance and intestinal health in diarrheic weanling piglets
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