Effects of dietary supplementation with the antimicrobial peptide WK3 on growth performance and intestinal health in diarrheic weanling piglets
This study aimed to determine the effects of the antimicrobial peptide WK3, as an alternative to antibiotics, on diarrheic piglets. Before treatment, all pigs were orally challenged with 10 8 CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatme...
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| Veröffentlicht in: | Journal of Applied Animal Research 2021-01, Vol.49 (1), p.147-153 |
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| creator | Cao, Chunyu Li, Jianan Ma, Qiuyuan Zhang, Licong Shan, Anshan |
| description | This study aimed to determine the effects of the antimicrobial peptide WK3, as an alternative to antibiotics, on diarrheic piglets. Before treatment, all pigs were orally challenged with 10
8
CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatments of eight piglets each, namely, the control treatment, antibiotic treatment and antimicrobial peptide treatment. The experimental results show that the addition of the antibacterial peptide WK3 to the diet can significantly reduce the chance of diarrhea. Compared with the CON group, average daily gain (ADG) and average daily feed intake (ADFI) of the WK3 group (P |
| doi_str_mv | 10.1080/09712119.2021.1916507 |
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8
CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatments of eight piglets each, namely, the control treatment, antibiotic treatment and antimicrobial peptide treatment. The experimental results show that the addition of the antibacterial peptide WK3 to the diet can significantly reduce the chance of diarrhea. Compared with the CON group, average daily gain (ADG) and average daily feed intake (ADFI) of the WK3 group (P < 0.05) increased. Compared with that with the control treatment and antibiotic treatment, the level of GSH-Px in the jejunum significantly increased (P < 0.05) with WK3 supplementation. The numbers of bacteria, Lactobacillus spp. (P < 0.01) and Bifidobacteria spp. (P < 0.01), were higher in the WK3 group, but Enterobacterium spp. in digesta of the cecum were depleted (P < 0.01). The WK3 group decreased the expression levels of the inflammatory factors IL-1α (P < 0.05) and TLR-4 (P < 0.01) in the jejunal mucosa contrast to the control treatment.]]></description><identifier>ISSN: 0971-2119</identifier><identifier>EISSN: 0974-1844</identifier><identifier>DOI: 10.1080/09712119.2021.1916507</identifier><language>eng</language><publisher>ABINGDON: Taylor & Francis</publisher><subject>Agriculture ; Agriculture, Dairy & Animal Science ; Antibiotics ; Antimicrobial peptide ; Antimicrobial peptides ; Cecum ; Diarrhea ; diarrhea incidence ; Feed additives ; growth performance ; Inflammation ; intestinal inflammation ; Jejunum ; Life Sciences & Biomedicine ; Mucosa ; Peptides ; Physical growth ; Science & Technology ; weaned piglets ; WK3</subject><ispartof>Journal of Applied Animal Research, 2021-01, Vol.49 (1), p.147-153</ispartof><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2021</rights><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000642108300001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c451t-f2bd5776535a260aa03954cb7727fb8e0b0761f0547fbcbc8ce44064528076363</citedby><cites>FETCH-LOGICAL-c451t-f2bd5776535a260aa03954cb7727fb8e0b0761f0547fbcbc8ce44064528076363</cites><orcidid>0000-0003-2830-7509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09712119.2021.1916507$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09712119.2021.1916507$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,866,2104,2116,27509,27931,27932,39265,59150,59151</link.rule.ids></links><search><creatorcontrib>Cao, Chunyu</creatorcontrib><creatorcontrib>Li, Jianan</creatorcontrib><creatorcontrib>Ma, Qiuyuan</creatorcontrib><creatorcontrib>Zhang, Licong</creatorcontrib><creatorcontrib>Shan, Anshan</creatorcontrib><title>Effects of dietary supplementation with the antimicrobial peptide WK3 on growth performance and intestinal health in diarrheic weanling piglets</title><title>Journal of Applied Animal Research</title><addtitle>J APPL ANIM RES</addtitle><description><![CDATA[This study aimed to determine the effects of the antimicrobial peptide WK3, as an alternative to antibiotics, on diarrheic piglets. Before treatment, all pigs were orally challenged with 10
8
CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatments of eight piglets each, namely, the control treatment, antibiotic treatment and antimicrobial peptide treatment. The experimental results show that the addition of the antibacterial peptide WK3 to the diet can significantly reduce the chance of diarrhea. Compared with the CON group, average daily gain (ADG) and average daily feed intake (ADFI) of the WK3 group (P < 0.05) increased. Compared with that with the control treatment and antibiotic treatment, the level of GSH-Px in the jejunum significantly increased (P < 0.05) with WK3 supplementation. The numbers of bacteria, Lactobacillus spp. (P < 0.01) and Bifidobacteria spp. (P < 0.01), were higher in the WK3 group, but Enterobacterium spp. in digesta of the cecum were depleted (P < 0.01). The WK3 group decreased the expression levels of the inflammatory factors IL-1α (P < 0.05) and TLR-4 (P < 0.01) in the jejunal mucosa contrast to the control treatment.]]></description><subject>Agriculture</subject><subject>Agriculture, Dairy & Animal Science</subject><subject>Antibiotics</subject><subject>Antimicrobial peptide</subject><subject>Antimicrobial peptides</subject><subject>Cecum</subject><subject>Diarrhea</subject><subject>diarrhea incidence</subject><subject>Feed additives</subject><subject>growth performance</subject><subject>Inflammation</subject><subject>intestinal inflammation</subject><subject>Jejunum</subject><subject>Life Sciences & Biomedicine</subject><subject>Mucosa</subject><subject>Peptides</subject><subject>Physical growth</subject><subject>Science & Technology</subject><subject>weaned piglets</subject><subject>WK3</subject><issn>0971-2119</issn><issn>0974-1844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>HGBXW</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNqNkcuKFDEUhgtRcBjnEYSAS6k296raKc2ogwNuFJchSSXdaaqTMknTzFPMK3uqa5ylmE2Sk_8_l3xN85bgDcE9_oCHjlBChg3FlGzIQKTA3YvmCuK8JT3nLy9n0i6i181NKQcMiw-MSnLVPN5672wtKHk0Bld1fkDlNM-TO7pYdQ0ponOoe1T3DulYwzHYnEzQE5rdXMPo0K9vDIFql9MZdLPLPuWjjnbRjyjE6koNEQx7pydQhAiVdM57Fyw6Ox2nEHdoDrvJ1fKmeeX1VNzN037d_Px8-2P7tb3__uVu--m-tVyQ2npqRtF1UjChqcRaYzYIbk3X0c6b3mGDO0k8Fhyu1tjeOs6x5IL28MAku27u1rxj0gc153CEyVXSQV0CKe-UzjXYySmCsfUcQyE_cNlp09OeWzEYyhkz2kCud2uuOaffJ5hWHdIpw8RFQW9D33Eil4piVcH_lZKdf65KsFpQqr8o1YJSPaEEX7_6zs4kX2xw8LXPXkApOQU7W6iSbViZbdMpVrC-_38rqD-u6hAvBM8pT6Oq-mFK2WcAGopi_-71Dw62xuE</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Cao, Chunyu</creator><creator>Li, Jianan</creator><creator>Ma, Qiuyuan</creator><creator>Zhang, Licong</creator><creator>Shan, Anshan</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2830-7509</orcidid></search><sort><creationdate>20210101</creationdate><title>Effects of dietary supplementation with the antimicrobial peptide WK3 on growth performance and intestinal health in diarrheic weanling piglets</title><author>Cao, Chunyu ; Li, Jianan ; Ma, Qiuyuan ; Zhang, Licong ; Shan, Anshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-f2bd5776535a260aa03954cb7727fb8e0b0761f0547fbcbc8ce44064528076363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Agriculture</topic><topic>Agriculture, Dairy & Animal Science</topic><topic>Antibiotics</topic><topic>Antimicrobial peptide</topic><topic>Antimicrobial peptides</topic><topic>Cecum</topic><topic>Diarrhea</topic><topic>diarrhea incidence</topic><topic>Feed additives</topic><topic>growth performance</topic><topic>Inflammation</topic><topic>intestinal inflammation</topic><topic>Jejunum</topic><topic>Life Sciences & Biomedicine</topic><topic>Mucosa</topic><topic>Peptides</topic><topic>Physical growth</topic><topic>Science & Technology</topic><topic>weaned piglets</topic><topic>WK3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Chunyu</creatorcontrib><creatorcontrib>Li, Jianan</creatorcontrib><creatorcontrib>Ma, Qiuyuan</creatorcontrib><creatorcontrib>Zhang, Licong</creatorcontrib><creatorcontrib>Shan, Anshan</creatorcontrib><collection>Taylor & Francis (Open Access)</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Applied Animal Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Chunyu</au><au>Li, Jianan</au><au>Ma, Qiuyuan</au><au>Zhang, Licong</au><au>Shan, Anshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dietary supplementation with the antimicrobial peptide WK3 on growth performance and intestinal health in diarrheic weanling piglets</atitle><jtitle>Journal of Applied Animal Research</jtitle><stitle>J APPL ANIM RES</stitle><date>2021-01-01</date><risdate>2021</risdate><volume>49</volume><issue>1</issue><spage>147</spage><epage>153</epage><pages>147-153</pages><issn>0971-2119</issn><eissn>0974-1844</eissn><abstract><![CDATA[This study aimed to determine the effects of the antimicrobial peptide WK3, as an alternative to antibiotics, on diarrheic piglets. Before treatment, all pigs were orally challenged with 10
8
CFU/ml enterotoxigenic Escherichia coli (ETEC) K88 for 3 days. Piglets were randomly divided into 3 treatments of eight piglets each, namely, the control treatment, antibiotic treatment and antimicrobial peptide treatment. The experimental results show that the addition of the antibacterial peptide WK3 to the diet can significantly reduce the chance of diarrhea. Compared with the CON group, average daily gain (ADG) and average daily feed intake (ADFI) of the WK3 group (P < 0.05) increased. Compared with that with the control treatment and antibiotic treatment, the level of GSH-Px in the jejunum significantly increased (P < 0.05) with WK3 supplementation. The numbers of bacteria, Lactobacillus spp. (P < 0.01) and Bifidobacteria spp. (P < 0.01), were higher in the WK3 group, but Enterobacterium spp. in digesta of the cecum were depleted (P < 0.01). The WK3 group decreased the expression levels of the inflammatory factors IL-1α (P < 0.05) and TLR-4 (P < 0.01) in the jejunal mucosa contrast to the control treatment.]]></abstract><cop>ABINGDON</cop><pub>Taylor & Francis</pub><doi>10.1080/09712119.2021.1916507</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2830-7509</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Agriculture Agriculture, Dairy & Animal Science Antibiotics Antimicrobial peptide Antimicrobial peptides Cecum Diarrhea diarrhea incidence Feed additives growth performance Inflammation intestinal inflammation Jejunum Life Sciences & Biomedicine Mucosa Peptides Physical growth Science & Technology weaned piglets WK3 |
| title | Effects of dietary supplementation with the antimicrobial peptide WK3 on growth performance and intestinal health in diarrheic weanling piglets |
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