In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats

While free thiols in monoclonal antibodies (mAbs) have been extensively characterized by in vitro studies to probe its effect on antibody function and stability, their in vivo biotransformation has not been comprehensively studied. In this study, a panel of five recombinant IgG1 mAbs with elevated f...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2021-05, Vol.110 (5), p.1989-1996
Hauptverfasser:	Kim, Michael T., Lechmann, Martin, Rajan, Sharmila, Shivva, Vittal, Lee, Aron, Chen, Yan, Weis, David D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical biochemistry Antibody(s) Biotechnology Chemistry Chemistry, Medicinal Chemistry, Multidisciplinary IgG antibody(s) Kinetics Life Sciences & Biomedicine Liquid chromatography-mass spectrometry (LC-MS) Monoclonal antibody(s) Oxidation(s) Pharmacology & Pharmacy Physical Sciences Physicochemical properties Reduction(s) Science & Technology
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