Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy

Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio...

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Veröffentlicht in:Applied radiation and isotopes 2021-06, Vol.172, Article 109693
Hauptverfasser: Tollefson, A. D., Smith, C. M., Carpenter, M. H., Croce, M. P., Fassbender, M. E., Koehler, K. E., Lilley, L. M., O'Brien, E. M., Schmidt, D. R., Stein, B. W., Ullom, J. N., Yoho, M. D., Mercer, D. J.
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container_title Applied radiation and isotopes
container_volume 172
creator Tollefson, A. D.
Smith, C. M.
Carpenter, M. H.
Croce, M. P.
Fassbender, M. E.
Koehler, K. E.
Lilley, L. M.
O'Brien, E. M.
Schmidt, D. R.
Stein, B. W.
Ullom, J. N.
Yoho, M. D.
Mercer, D. J.
description Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.
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Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. 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subjects Chemistry
Chemistry, Inorganic & Nuclear
Life Sciences & Biomedicine
Nuclear Science & Technology
Physical Sciences
Radiology, Nuclear Medicine & Medical Imaging
Science & Technology
Technology
title Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy
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