Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy

Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Applied radiation and isotopes 2021-06, Vol.172, Article 109693
Hauptverfasser: Tollefson, A. D., Smith, C. M., Carpenter, M. H., Croce, M. P., Fassbender, M. E., Koehler, K. E., Lilley, L. M., O'Brien, E. M., Schmidt, D. R., Stein, B. W., Ullom, J. N., Yoho, M. D., Mercer, D. J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title Applied radiation and isotopes
container_volume 172
creator Tollefson, A. D.
Smith, C. M.
Carpenter, M. H.
Croce, M. P.
Fassbender, M. E.
Koehler, K. E.
Lilley, L. M.
O'Brien, E. M.
Schmidt, D. R.
Stein, B. W.
Ullom, J. N.
Yoho, M. D.
Mercer, D. J.
description Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.
doi_str_mv 10.1016/j.apradiso.2021.109693
format Article
fullrecord <record><control><sourceid>webofscience</sourceid><recordid>TN_cdi_webofscience_primary_000640178800029CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>000640178800029</sourcerecordid><originalsourceid>FETCH-webofscience_primary_0006401788000293</originalsourceid><addsrcrecordid>eNqVjsFKxDAURYMoTmf0FyRLRVpfktqky6GM6GJ27oeYeR0y2CQkKZK_t4IfoKsLhwvnEHLHoGHAuqdzo0PUR5t8w4GzBfZdLy5IxZTkda8ALkn1w2oFrViRdUpnAGhVz6_JSggpW8FFRd72qNMccUKXqR_pPefyYTtQO4U52lyodXRras6f6ZysO9EjGl0oOoynQlNAk6NPxodyQ65G_Znw9nc35PFl9z681l_44cdkLDqDhxDtpGM5LC1dC0yqpRR4LzZE_f092Kyz9W7ws8vif6Jv_YNclA</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy</title><source>Elsevier ScienceDirect Journals Complete</source><source>Web of Science - Science Citation Index Expanded - 2021&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><creator>Tollefson, A. D. ; Smith, C. M. ; Carpenter, M. H. ; Croce, M. P. ; Fassbender, M. E. ; Koehler, K. E. ; Lilley, L. M. ; O'Brien, E. M. ; Schmidt, D. R. ; Stein, B. W. ; Ullom, J. N. ; Yoho, M. D. ; Mercer, D. J.</creator><creatorcontrib>Tollefson, A. D. ; Smith, C. M. ; Carpenter, M. H. ; Croce, M. P. ; Fassbender, M. E. ; Koehler, K. E. ; Lilley, L. M. ; O'Brien, E. M. ; Schmidt, D. R. ; Stein, B. W. ; Ullom, J. N. ; Yoho, M. D. ; Mercer, D. J.</creatorcontrib><description>Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.</description><identifier>ISSN: 0969-8043</identifier><identifier>EISSN: 1872-9800</identifier><identifier>DOI: 10.1016/j.apradiso.2021.109693</identifier><identifier>PMID: 33774323</identifier><language>eng</language><publisher>OXFORD: Elsevier</publisher><subject>Chemistry ; Chemistry, Inorganic &amp; Nuclear ; Life Sciences &amp; Biomedicine ; Nuclear Science &amp; Technology ; Physical Sciences ; Radiology, Nuclear Medicine &amp; Medical Imaging ; Science &amp; Technology ; Technology</subject><ispartof>Applied radiation and isotopes, 2021-06, Vol.172, Article 109693</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>9</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000640178800029</woscitedreferencesoriginalsourcerecordid><cites>FETCH-webofscience_primary_0006401788000293</cites><orcidid>0000-0002-9213-3614</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932,39265</link.rule.ids></links><search><creatorcontrib>Tollefson, A. D.</creatorcontrib><creatorcontrib>Smith, C. M.</creatorcontrib><creatorcontrib>Carpenter, M. H.</creatorcontrib><creatorcontrib>Croce, M. P.</creatorcontrib><creatorcontrib>Fassbender, M. E.</creatorcontrib><creatorcontrib>Koehler, K. E.</creatorcontrib><creatorcontrib>Lilley, L. M.</creatorcontrib><creatorcontrib>O'Brien, E. M.</creatorcontrib><creatorcontrib>Schmidt, D. R.</creatorcontrib><creatorcontrib>Stein, B. W.</creatorcontrib><creatorcontrib>Ullom, J. N.</creatorcontrib><creatorcontrib>Yoho, M. D.</creatorcontrib><creatorcontrib>Mercer, D. J.</creatorcontrib><title>Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy</title><title>Applied radiation and isotopes</title><addtitle>APPL RADIAT ISOTOPES</addtitle><description>Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.</description><subject>Chemistry</subject><subject>Chemistry, Inorganic &amp; Nuclear</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>Nuclear Science &amp; Technology</subject><subject>Physical Sciences</subject><subject>Radiology, Nuclear Medicine &amp; Medical Imaging</subject><subject>Science &amp; Technology</subject><subject>Technology</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqVjsFKxDAURYMoTmf0FyRLRVpfktqky6GM6GJ27oeYeR0y2CQkKZK_t4IfoKsLhwvnEHLHoGHAuqdzo0PUR5t8w4GzBfZdLy5IxZTkda8ALkn1w2oFrViRdUpnAGhVz6_JSggpW8FFRd72qNMccUKXqR_pPefyYTtQO4U52lyodXRras6f6ZysO9EjGl0oOoynQlNAk6NPxodyQ65G_Znw9nc35PFl9z681l_44cdkLDqDhxDtpGM5LC1dC0yqpRR4LzZE_f092Kyz9W7ws8vif6Jv_YNclA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Tollefson, A. D.</creator><creator>Smith, C. M.</creator><creator>Carpenter, M. H.</creator><creator>Croce, M. P.</creator><creator>Fassbender, M. E.</creator><creator>Koehler, K. E.</creator><creator>Lilley, L. M.</creator><creator>O'Brien, E. M.</creator><creator>Schmidt, D. R.</creator><creator>Stein, B. W.</creator><creator>Ullom, J. N.</creator><creator>Yoho, M. D.</creator><creator>Mercer, D. J.</creator><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><orcidid>https://orcid.org/0000-0002-9213-3614</orcidid></search><sort><creationdate>20210601</creationdate><title>Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy</title><author>Tollefson, A. D. ; Smith, C. M. ; Carpenter, M. H. ; Croce, M. P. ; Fassbender, M. E. ; Koehler, K. E. ; Lilley, L. M. ; O'Brien, E. M. ; Schmidt, D. R. ; Stein, B. W. ; Ullom, J. N. ; Yoho, M. D. ; Mercer, D. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-webofscience_primary_0006401788000293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chemistry</topic><topic>Chemistry, Inorganic &amp; Nuclear</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>Nuclear Science &amp; Technology</topic><topic>Physical Sciences</topic><topic>Radiology, Nuclear Medicine &amp; Medical Imaging</topic><topic>Science &amp; Technology</topic><topic>Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tollefson, A. D.</creatorcontrib><creatorcontrib>Smith, C. M.</creatorcontrib><creatorcontrib>Carpenter, M. H.</creatorcontrib><creatorcontrib>Croce, M. P.</creatorcontrib><creatorcontrib>Fassbender, M. E.</creatorcontrib><creatorcontrib>Koehler, K. E.</creatorcontrib><creatorcontrib>Lilley, L. M.</creatorcontrib><creatorcontrib>O'Brien, E. M.</creatorcontrib><creatorcontrib>Schmidt, D. R.</creatorcontrib><creatorcontrib>Stein, B. W.</creatorcontrib><creatorcontrib>Ullom, J. N.</creatorcontrib><creatorcontrib>Yoho, M. D.</creatorcontrib><creatorcontrib>Mercer, D. J.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><jtitle>Applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tollefson, A. D.</au><au>Smith, C. M.</au><au>Carpenter, M. H.</au><au>Croce, M. P.</au><au>Fassbender, M. E.</au><au>Koehler, K. E.</au><au>Lilley, L. M.</au><au>O'Brien, E. M.</au><au>Schmidt, D. R.</au><au>Stein, B. W.</au><au>Ullom, J. N.</au><au>Yoho, M. D.</au><au>Mercer, D. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy</atitle><jtitle>Applied radiation and isotopes</jtitle><stitle>APPL RADIAT ISOTOPES</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>172</volume><artnum>109693</artnum><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.</abstract><cop>OXFORD</cop><pub>Elsevier</pub><pmid>33774323</pmid><doi>10.1016/j.apradiso.2021.109693</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9213-3614</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0969-8043
ispartof Applied radiation and isotopes, 2021-06, Vol.172, Article 109693
issn 0969-8043
1872-9800
language eng
recordid cdi_webofscience_primary_000640178800029CitationCount
source Elsevier ScienceDirect Journals Complete; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />
subjects Chemistry
Chemistry, Inorganic & Nuclear
Life Sciences & Biomedicine
Nuclear Science & Technology
Physical Sciences
Radiology, Nuclear Medicine & Medical Imaging
Science & Technology
Technology
title Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T03%3A04%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-webofscience&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Measurement%20of%20(227)AC%20impurity%20in%20Ac-225%20using%20decay%20energy%20spectroscopy&rft.jtitle=Applied%20radiation%20and%20isotopes&rft.au=Tollefson,%20A.%20D.&rft.date=2021-06-01&rft.volume=172&rft.artnum=109693&rft.issn=0969-8043&rft.eissn=1872-9800&rft_id=info:doi/10.1016/j.apradiso.2021.109693&rft_dat=%3Cwebofscience%3E000640178800029%3C/webofscience%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/33774323&rfr_iscdi=true