Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy
Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio...
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creator | Tollefson, A. D. Smith, C. M. Carpenter, M. H. Croce, M. P. Fassbender, M. E. Koehler, K. E. Lilley, L. M. O'Brien, E. M. Schmidt, D. R. Stein, B. W. Ullom, J. N. Yoho, M. D. Mercer, D. J. |
description | Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra. |
doi_str_mv | 10.1016/j.apradiso.2021.109693 |
format | Article |
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D. ; Smith, C. M. ; Carpenter, M. H. ; Croce, M. P. ; Fassbender, M. E. ; Koehler, K. E. ; Lilley, L. M. ; O'Brien, E. M. ; Schmidt, D. R. ; Stein, B. W. ; Ullom, J. N. ; Yoho, M. D. ; Mercer, D. J.</creator><creatorcontrib>Tollefson, A. D. ; Smith, C. M. ; Carpenter, M. H. ; Croce, M. P. ; Fassbender, M. E. ; Koehler, K. E. ; Lilley, L. M. ; O'Brien, E. M. ; Schmidt, D. R. ; Stein, B. W. ; Ullom, J. N. ; Yoho, M. D. ; Mercer, D. J.</creatorcontrib><description>Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.</description><identifier>ISSN: 0969-8043</identifier><identifier>EISSN: 1872-9800</identifier><identifier>DOI: 10.1016/j.apradiso.2021.109693</identifier><identifier>PMID: 33774323</identifier><language>eng</language><publisher>OXFORD: Elsevier</publisher><subject>Chemistry ; Chemistry, Inorganic & Nuclear ; Life Sciences & Biomedicine ; Nuclear Science & Technology ; Physical Sciences ; Radiology, Nuclear Medicine & Medical Imaging ; Science & Technology ; Technology</subject><ispartof>Applied radiation and isotopes, 2021-06, Vol.172, Article 109693</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>9</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000640178800029</woscitedreferencesoriginalsourcerecordid><cites>FETCH-webofscience_primary_0006401788000293</cites><orcidid>0000-0002-9213-3614</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932,39265</link.rule.ids></links><search><creatorcontrib>Tollefson, A. 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Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.</description><subject>Chemistry</subject><subject>Chemistry, Inorganic & Nuclear</subject><subject>Life Sciences & Biomedicine</subject><subject>Nuclear Science & Technology</subject><subject>Physical Sciences</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Science & Technology</subject><subject>Technology</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqVjsFKxDAURYMoTmf0FyRLRVpfktqky6GM6GJ27oeYeR0y2CQkKZK_t4IfoKsLhwvnEHLHoGHAuqdzo0PUR5t8w4GzBfZdLy5IxZTkda8ALkn1w2oFrViRdUpnAGhVz6_JSggpW8FFRd72qNMccUKXqR_pPefyYTtQO4U52lyodXRras6f6ZysO9EjGl0oOoynQlNAk6NPxodyQ65G_Znw9nc35PFl9z681l_44cdkLDqDhxDtpGM5LC1dC0yqpRR4LzZE_f092Kyz9W7ws8vif6Jv_YNclA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Tollefson, A. 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J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy</atitle><jtitle>Applied radiation and isotopes</jtitle><stitle>APPL RADIAT ISOTOPES</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>172</volume><artnum>109693</artnum><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>Ac-225 is a valuable medical radionuclide for targeted alpha therapy, but Ac-227 is an undesirable byproduct of an accelerator-based synthesis method under investigation. Sufficient detector sensitivity is critical for quantifying the trace impurity of( 227)Ac, with the Ac-227/Ac-225 activity ratio predicted to be approximately 0.15% by end-of-bombardment (EOB). Superconducting transition edge sensor (TES) microcalorimeters offer high resolution energy spectroscopy using the normal-to-superconducting phase transition to measure small changes in temperature. By embedding Ac-225 production samples in a gold foil thermally coupled to a TES microcalorimeter we can measure the decay energies of the radionuclides embedded with high resolution and 100% detection efficiency. This technique, known as decay energy spectroscopy (DES), collapses several peaks from a decays into single Q-value peaks. In practice there are more complex factors in the interpretation of data using DES, which we will discuss herein. Using this technique we measured the EOB Ac-227 impurity to be (0.142 +/- 0.005)% for a single production sample. This demonstration has shown that DES is a useful tool for quantitative measurements of complicated spectra.</abstract><cop>OXFORD</cop><pub>Elsevier</pub><pmid>33774323</pmid><doi>10.1016/j.apradiso.2021.109693</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9213-3614</orcidid></addata></record> |
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subjects | Chemistry Chemistry, Inorganic & Nuclear Life Sciences & Biomedicine Nuclear Science & Technology Physical Sciences Radiology, Nuclear Medicine & Medical Imaging Science & Technology Technology |
title | Measurement of (227)AC impurity in Ac-225 using decay energy spectroscopy |
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