Dietary spermidine improves cognitive function

Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural autophagy-promoting polyamine. Here,...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-04, Vol.35 (2), p.108985, Article 108985
Hauptverfasser:	Schroeder, Sabrina, Hofer, Sebastian J., Zimmermann, Andreas, Pechlaner, Raimund, Dammbrueck, Christopher, Pendl, Tobias, Marcello, G. Mark, Pogatschnigg, Viktoria, Bergmann, Martina, Müller, Melanie, Gschiel, Verena, Ristic, Selena, Tadic, Jelena, Iwata, Keiko, Richter, Gesa, Farzi, Aitak, Üçal, Muammer, Schäfer, Ute, Poglitsch, Michael, Royer, Philipp, Mekis, Ronald, Agreiter, Marlene, Tölle, Regine C., Sótonyi, Péter, Willeit, Johann, Mairhofer, Barbara, Niederkofler, Helga, Pallhuber, Irmgard, Rungger, Gregorio, Tilg, Herbert, Defrancesco, Michaela, Marksteiner, Josef, Sinner, Frank, Magnes, Christoph, Pieber, Thomas R., Holzer, Peter, Kroemer, Guido, Carmona-Gutierrez, Didac, Scorrano, Luca, Dengjel, Jörn, Madl, Tobias, Sedej, Simon, Sigrist, Stephan J., Rácz, Bence, Kiechl, Stefan, Eisenberg, Tobias, Madeo, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - genetics Aging - metabolism Animals autophagy Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Brain - cytology Brain - drug effects Brain - growth & development Brain - metabolism Cognition - drug effects Cognition - physiology Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Cognitive Dysfunction - physiopathology Cognitive Dysfunction - prevention & control cognitive function Cognitive Sciences dietary spermidine Dietary Supplements Drosophila melanogaster - drug effects Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Female Food and Nutrition Gene Expression Regulation Humans Learning - drug effects Learning - physiology Life Sciences Male memory Mice mitochondria Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism mitophagy Neurons - drug effects Neurons - metabolism Neurons and Cognition Oxidative Phosphorylation - drug effects Pink1 Protein Kinases - genetics Protein Kinases - metabolism Signal Transduction Spatial Memory - drug effects Spatial Memory - physiology Spermidine - pharmacology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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