The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2

The cellular entry of severe acute respiratory syndrome-associated coronaviruses types 1 and 2 (SARS-CoV-1 and -2) requires sequential protease processing of the viral spike glycoprotein. The presence of a polybasic cleavage site in SARSCoV-2 spike at the S1/S2 boundary has been suggested to be a fa...

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Veröffentlicht in:	Journal of virology 2021-04, Vol.95 (9), Article 02422
Hauptverfasser:	Winstone, Helena, Lista, Maria Jose, Reid, Alisha C., Bouton, Clement, Pickering, Suzanne, Galao, Rui Pedro, Kerridge, Claire, Doores, Katie J., Swanson, Chad M., Neil, Stuart J. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Cellular Response to Infection Humans Interferon Type I - genetics Interferon Type I - metabolism Life Sciences & Biomedicine Membrane Proteins - genetics Membrane Proteins - metabolism Proteolysis SARS-CoV-2 - physiology Science & Technology Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Virology Virus Internalization Virus Replication
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