Left Atrial Strain changes in patients with breast cancer during anthracycline therapy
Cardiotoxicity has become a significant adverse effect of cancer therapy, with Anthracyclines (ANT) in particular. There is a crucial need for new imaging techniques for the early subclinical detection of cardiotoxic effect. We aimed to evaluate left atrial strain (LAS) changes during ANT therapy an...
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| Veröffentlicht in: | International journal of cardiology 2021-05, Vol.330, p.238-244 |
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| creator | Laufer-Perl, Michal Arias, Orly Dorfman, Svetlana Sirota Baruch, Guy Rothschild, Ehud Beer, Gil Hasson, Shira Peleg Arbel, Yaron Rozenbaum, Zach Topilsky, Yan Kapusta, Livia |
| description | Cardiotoxicity has become a significant adverse effect of cancer therapy, with Anthracyclines (ANT) in particular. There is a crucial need for new imaging techniques for the early subclinical detection of cardiotoxic effect. We aimed to evaluate left atrial strain (LAS) changes during ANT therapy and to assess the correlation between LAS and the routine echocardiographic diastolic parameters.
Data were prospectively collected as part of the Israel Cardio-Oncology Registry (ICOR). All female patients with breast cancer, planned for ANT therapy were included. All patients underwent serial echocardiography exams including baseline LAS (before chemotherapy, T1) and shortly after the completion of ANT therapy (T3). LAS was assessed in 3 phases: Reservoir (LASr), Conduit (LASc) and Pump (LASp). Significant reduction in LASr was determined by either a relative reduction of >10% or an absolute value of |
| doi_str_mv | 10.1016/j.ijcard.2021.02.013 |
| format | Article |
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Data were prospectively collected as part of the Israel Cardio-Oncology Registry (ICOR). All female patients with breast cancer, planned for ANT therapy were included. All patients underwent serial echocardiography exams including baseline LAS (before chemotherapy, T1) and shortly after the completion of ANT therapy (T3). LAS was assessed in 3 phases: Reservoir (LASr), Conduit (LASc) and Pump (LASp). Significant reduction in LASr was determined by either a relative reduction of >10% or an absolute value of <35%. From September 2016 to June 2019, 40 patients were evaluated with a mean Doxorubicin (type of ANT) dose of 237±13.24mg/m2. At T3, significant reduction in LASr was observed among 50% of the patients with a mean LASr reduction from 40.15 ± 6.83% to 36.04 ± 7.73% (p < 0.001). LASc showed significant reduction as well (p < 0.004) as opposed to LASp (p=0.076). Both LASr and LASc showed significant correlation to the routine diastolic parameters.
LASr and LASc reduction are frequent and occur early in the course of ANT therapy, showing significant correlation to the routine echocardiographic diastolic parameters, which may imply a role in the detection of early cardiotoxicity.
•Novel echocardiography strain evaluation among breast cancer patients•Left Atrial Strain changes for early cardiac injury assessment•Left Atrial Strain reduction is frequent among anthracycline patients•Left Atrial Strain showed significant correlation to diastolic parameters</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2021.02.013</identifier><identifier>PMID: 33581179</identifier><language>eng</language><publisher>CLARE: Elsevier B.V</publisher><subject>Cardiac & Cardiovascular Systems ; Cardio-oncology ; Cardiotoxicity ; Cardiovascular System & Cardiology ; Chemotherapy ; Echocardiography ; Left atrial ; Life Sciences & Biomedicine ; Science & Technology ; Strain</subject><ispartof>International journal of cardiology, 2021-05, Vol.330, p.238-244</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>23</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000637586400045</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c362t-79f675c86593c1e06f4c6919b036416e603ebf4189cb03de976586d4a88f50f73</citedby><cites>FETCH-LOGICAL-c362t-79f675c86593c1e06f4c6919b036416e603ebf4189cb03de976586d4a88f50f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2021.02.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33581179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laufer-Perl, Michal</creatorcontrib><creatorcontrib>Arias, Orly</creatorcontrib><creatorcontrib>Dorfman, Svetlana Sirota</creatorcontrib><creatorcontrib>Baruch, Guy</creatorcontrib><creatorcontrib>Rothschild, Ehud</creatorcontrib><creatorcontrib>Beer, Gil</creatorcontrib><creatorcontrib>Hasson, Shira Peleg</creatorcontrib><creatorcontrib>Arbel, Yaron</creatorcontrib><creatorcontrib>Rozenbaum, Zach</creatorcontrib><creatorcontrib>Topilsky, Yan</creatorcontrib><creatorcontrib>Kapusta, Livia</creatorcontrib><title>Left Atrial Strain changes in patients with breast cancer during anthracycline therapy</title><title>International journal of cardiology</title><addtitle>INT J CARDIOL</addtitle><addtitle>Int J Cardiol</addtitle><description>Cardiotoxicity has become a significant adverse effect of cancer therapy, with Anthracyclines (ANT) in particular. There is a crucial need for new imaging techniques for the early subclinical detection of cardiotoxic effect. We aimed to evaluate left atrial strain (LAS) changes during ANT therapy and to assess the correlation between LAS and the routine echocardiographic diastolic parameters.
Data were prospectively collected as part of the Israel Cardio-Oncology Registry (ICOR). All female patients with breast cancer, planned for ANT therapy were included. All patients underwent serial echocardiography exams including baseline LAS (before chemotherapy, T1) and shortly after the completion of ANT therapy (T3). LAS was assessed in 3 phases: Reservoir (LASr), Conduit (LASc) and Pump (LASp). Significant reduction in LASr was determined by either a relative reduction of >10% or an absolute value of <35%. From September 2016 to June 2019, 40 patients were evaluated with a mean Doxorubicin (type of ANT) dose of 237±13.24mg/m2. At T3, significant reduction in LASr was observed among 50% of the patients with a mean LASr reduction from 40.15 ± 6.83% to 36.04 ± 7.73% (p < 0.001). LASc showed significant reduction as well (p < 0.004) as opposed to LASp (p=0.076). Both LASr and LASc showed significant correlation to the routine diastolic parameters.
LASr and LASc reduction are frequent and occur early in the course of ANT therapy, showing significant correlation to the routine echocardiographic diastolic parameters, which may imply a role in the detection of early cardiotoxicity.
•Novel echocardiography strain evaluation among breast cancer patients•Left Atrial Strain changes for early cardiac injury assessment•Left Atrial Strain reduction is frequent among anthracycline patients•Left Atrial Strain showed significant correlation to diastolic parameters</description><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardio-oncology</subject><subject>Cardiotoxicity</subject><subject>Cardiovascular System & Cardiology</subject><subject>Chemotherapy</subject><subject>Echocardiography</subject><subject>Left atrial</subject><subject>Life Sciences & Biomedicine</subject><subject>Science & Technology</subject><subject>Strain</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkF1rHCEUQKUkNNuk_6AU38NMdXT8eCmEJWkLC33Ix6s4zjXrsnEWdRP238dl0jyGPilyzuV6EPpGSUsJFT82bdg4m8a2Ix1tSdcSyj6hBVWSN1T2_AQtKiabvpPsDH3JeUMI4Vqrz-iMsV5RKvUCPazAF3xVUrBbfFuSDRG7tY2PkHG97mwJEEvGL6Gs8ZDA5oKdjQ4SHvcpxEdsY1kn6w5uGyLgsoZkd4cLdOrtNsPXt_Mc3d9c3y1_N6u_v_4sr1aNY6IrjdReyN4p0WvmKBDhuROa6oEwwakAQRgMnlOlXX0aQUvRKzFyq5TviZfsHPF5rktTzgm82aXwZNPBUGKOmczGzJnMMZMhnamZqvZ91nb74QnGd-lflwpczsALDJPPrkZw8I7VkILJugk_Ju0rrf6fXoZSo05xOe1jqerPWYVa6TlAMm_6GBK4YsYpfPyVVwJIm5g</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Laufer-Perl, Michal</creator><creator>Arias, Orly</creator><creator>Dorfman, Svetlana Sirota</creator><creator>Baruch, Guy</creator><creator>Rothschild, Ehud</creator><creator>Beer, Gil</creator><creator>Hasson, Shira Peleg</creator><creator>Arbel, Yaron</creator><creator>Rozenbaum, Zach</creator><creator>Topilsky, Yan</creator><creator>Kapusta, Livia</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20210501</creationdate><title>Left Atrial Strain changes in patients with breast cancer during anthracycline therapy</title><author>Laufer-Perl, Michal ; Arias, Orly ; Dorfman, Svetlana Sirota ; Baruch, Guy ; Rothschild, Ehud ; Beer, Gil ; Hasson, Shira Peleg ; Arbel, Yaron ; Rozenbaum, Zach ; Topilsky, Yan ; Kapusta, Livia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-79f675c86593c1e06f4c6919b036416e603ebf4189cb03de976586d4a88f50f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardio-oncology</topic><topic>Cardiotoxicity</topic><topic>Cardiovascular System & Cardiology</topic><topic>Chemotherapy</topic><topic>Echocardiography</topic><topic>Left atrial</topic><topic>Life Sciences & Biomedicine</topic><topic>Science & Technology</topic><topic>Strain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laufer-Perl, Michal</creatorcontrib><creatorcontrib>Arias, Orly</creatorcontrib><creatorcontrib>Dorfman, Svetlana Sirota</creatorcontrib><creatorcontrib>Baruch, Guy</creatorcontrib><creatorcontrib>Rothschild, Ehud</creatorcontrib><creatorcontrib>Beer, Gil</creatorcontrib><creatorcontrib>Hasson, Shira Peleg</creatorcontrib><creatorcontrib>Arbel, Yaron</creatorcontrib><creatorcontrib>Rozenbaum, Zach</creatorcontrib><creatorcontrib>Topilsky, Yan</creatorcontrib><creatorcontrib>Kapusta, Livia</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laufer-Perl, Michal</au><au>Arias, Orly</au><au>Dorfman, Svetlana Sirota</au><au>Baruch, Guy</au><au>Rothschild, Ehud</au><au>Beer, Gil</au><au>Hasson, Shira Peleg</au><au>Arbel, Yaron</au><au>Rozenbaum, Zach</au><au>Topilsky, Yan</au><au>Kapusta, Livia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left Atrial Strain changes in patients with breast cancer during anthracycline therapy</atitle><jtitle>International journal of cardiology</jtitle><stitle>INT J CARDIOL</stitle><addtitle>Int J Cardiol</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>330</volume><spage>238</spage><epage>244</epage><pages>238-244</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Cardiotoxicity has become a significant adverse effect of cancer therapy, with Anthracyclines (ANT) in particular. There is a crucial need for new imaging techniques for the early subclinical detection of cardiotoxic effect. We aimed to evaluate left atrial strain (LAS) changes during ANT therapy and to assess the correlation between LAS and the routine echocardiographic diastolic parameters.
Data were prospectively collected as part of the Israel Cardio-Oncology Registry (ICOR). All female patients with breast cancer, planned for ANT therapy were included. All patients underwent serial echocardiography exams including baseline LAS (before chemotherapy, T1) and shortly after the completion of ANT therapy (T3). LAS was assessed in 3 phases: Reservoir (LASr), Conduit (LASc) and Pump (LASp). Significant reduction in LASr was determined by either a relative reduction of >10% or an absolute value of <35%. From September 2016 to June 2019, 40 patients were evaluated with a mean Doxorubicin (type of ANT) dose of 237±13.24mg/m2. At T3, significant reduction in LASr was observed among 50% of the patients with a mean LASr reduction from 40.15 ± 6.83% to 36.04 ± 7.73% (p < 0.001). LASc showed significant reduction as well (p < 0.004) as opposed to LASp (p=0.076). Both LASr and LASc showed significant correlation to the routine diastolic parameters.
LASr and LASc reduction are frequent and occur early in the course of ANT therapy, showing significant correlation to the routine echocardiographic diastolic parameters, which may imply a role in the detection of early cardiotoxicity.
•Novel echocardiography strain evaluation among breast cancer patients•Left Atrial Strain changes for early cardiac injury assessment•Left Atrial Strain reduction is frequent among anthracycline patients•Left Atrial Strain showed significant correlation to diastolic parameters</abstract><cop>CLARE</cop><pub>Elsevier B.V</pub><pmid>33581179</pmid><doi>10.1016/j.ijcard.2021.02.013</doi><tpages>7</tpages></addata></record> |
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| subjects | Cardiac & Cardiovascular Systems Cardio-oncology Cardiotoxicity Cardiovascular System & Cardiology Chemotherapy Echocardiography Left atrial Life Sciences & Biomedicine Science & Technology Strain |
| title | Left Atrial Strain changes in patients with breast cancer during anthracycline therapy |
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