Peripheral Macrophage-derived Exosomes promote repair after Spinal Cord Injury by inducing Local Anti-inflammatory type Microglial Polarization via Increasing Autophagy

Treatment for spinal cord injury (SCI) remains a challenge worldwide, and inflammation is a major cause of secondary injury after SCI. Peripheral macrophages (PMs) have been verified as a key factor that exert anti-inflammatory effects after SCI, but the mechanism is unidentified. As local macrophag...

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Veröffentlicht in:	International journal of biological sciences 2021-01, Vol.17 (5), p.1339-1352
Hauptverfasser:	Zhang, Baokun, Lin, Fangqi, Dong, Jiqing, Liu, Jingwen, Ding, Zhenyu, Xu, Jianguang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antibodies Autophagy Autophagy - immunology Cell Polarity - physiology Cell-Derived Microparticles - immunology Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - transplantation Chemical compounds Contusions Exosomes Exosomes - immunology Exosomes - metabolism Exosomes - transplantation In vivo methods and tests Inflammation Inflammation - metabolism Inflammation - therapy Laboratory animals Macrophages Macrophages - immunology Microglia Microglia - immunology Microglia - metabolism Phagocytosis Pharmacology Phosphatidylinositol 3-Kinases - metabolism Polarization Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Reagents Recovery of Function - physiology Research Paper Signal Transduction Signal transmission Signaling Spinal cord injuries Spinal Cord Injuries - immunology Spinal Cord Injuries - metabolism Spinal Cord Injuries - therapy TOR protein TOR Serine-Threonine Kinases - metabolism Treatment Outcome
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