Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas
Objectives The use of stereotactic body radiation therapy (SBRT) has not been assessed in advanced-stage feline solar-induced facial squamous cell carcinomas (SCCs). The objective of this study was to provide preliminary data on the use and safety profile of coarse fractions administered with an SBR...
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| Veröffentlicht in: | Journal of feline medicine and surgery 2021-12, Vol.23 (12), p.1081-1088, Article 1098612 |
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| container_title | Journal of feline medicine and surgery |
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| creator | Swan, Michaela B Morrow, Deanna M Lurie, David M |
| description | Objectives
The use of stereotactic body radiation therapy (SBRT) has not been assessed in advanced-stage feline solar-induced facial squamous cell carcinomas (SCCs). The objective of this study was to provide preliminary data on the use and safety profile of coarse fractions administered with an SBRT regime to manage advanced-stage feline solar-induced facial SCCs.
Methods
This retrospective study assessed five cats diagnosed with advanced-stage solar-induced facial SCCs that received SBRT as their primary treatment or, in one cat, following failed surgical intervention. Tumour sites received three fractions totalling 26.25–27 Gy over a 3–5-day period.
Results
All patients developed acute effects following SBRT including alopecia, epilation and erythema. Late effects were mild and included alopecia, variable pigmentation and leukotrichia within radiation fields. All patients were alive at the time of article submission, with overall survival times ranging from 118 to 991 days.
Conclusions and relevance
The results suggest that coarse fractions administered with an SBRT technique is a safe and effective treatment tool for the management of advanced-stage feline solar-induced facial SCCs. These data provide preliminary evidence to support larger, prospective studies evaluating the management of feline facial SCCs with SBRT. |
| doi_str_mv | 10.1177/1098612X21994391 |
| format | Article |
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The use of stereotactic body radiation therapy (SBRT) has not been assessed in advanced-stage feline solar-induced facial squamous cell carcinomas (SCCs). The objective of this study was to provide preliminary data on the use and safety profile of coarse fractions administered with an SBRT regime to manage advanced-stage feline solar-induced facial SCCs.
Methods
This retrospective study assessed five cats diagnosed with advanced-stage solar-induced facial SCCs that received SBRT as their primary treatment or, in one cat, following failed surgical intervention. Tumour sites received three fractions totalling 26.25–27 Gy over a 3–5-day period.
Results
All patients developed acute effects following SBRT including alopecia, epilation and erythema. Late effects were mild and included alopecia, variable pigmentation and leukotrichia within radiation fields. All patients were alive at the time of article submission, with overall survival times ranging from 118 to 991 days.
Conclusions and relevance
The results suggest that coarse fractions administered with an SBRT technique is a safe and effective treatment tool for the management of advanced-stage feline solar-induced facial SCCs. These data provide preliminary evidence to support larger, prospective studies evaluating the management of feline facial SCCs with SBRT.</description><identifier>ISSN: 1098-612X</identifier><identifier>ISSN: 1532-2750</identifier><identifier>EISSN: 1532-2750</identifier><identifier>DOI: 10.1177/1098612X21994391</identifier><identifier>PMID: 33615873</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - veterinary ; Cat Diseases - radiotherapy ; Cats ; Life Sciences & Biomedicine ; Original ; Pilot Projects ; Prospective Studies ; Radiosurgery - veterinary ; Retrospective Studies ; Science & Technology ; Veterinary Sciences</subject><ispartof>Journal of feline medicine and surgery, 2021-12, Vol.23 (12), p.1081-1088, Article 1098612</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021 2021 International Society of Feline Medicine and American Association of Feline Practitioners</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000632155400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c435t-a4f144474db3a46fbbed22a86e46ad61054d3618ddc993b8bae5ef7c203221143</citedby><cites>FETCH-LOGICAL-c435t-a4f144474db3a46fbbed22a86e46ad61054d3618ddc993b8bae5ef7c203221143</cites><orcidid>0000-0002-0769-4960</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10812163/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10812163/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,21971,27858,27929,27930,39263,44950,45338,53796,53798</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1098612X21994391?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33615873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swan, Michaela B</creatorcontrib><creatorcontrib>Morrow, Deanna M</creatorcontrib><creatorcontrib>Lurie, David M</creatorcontrib><title>Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas</title><title>Journal of feline medicine and surgery</title><addtitle>J FELINE MED SURG</addtitle><addtitle>J Feline Med Surg</addtitle><description>Objectives
The use of stereotactic body radiation therapy (SBRT) has not been assessed in advanced-stage feline solar-induced facial squamous cell carcinomas (SCCs). The objective of this study was to provide preliminary data on the use and safety profile of coarse fractions administered with an SBRT regime to manage advanced-stage feline solar-induced facial SCCs.
Methods
This retrospective study assessed five cats diagnosed with advanced-stage solar-induced facial SCCs that received SBRT as their primary treatment or, in one cat, following failed surgical intervention. Tumour sites received three fractions totalling 26.25–27 Gy over a 3–5-day period.
Results
All patients developed acute effects following SBRT including alopecia, epilation and erythema. Late effects were mild and included alopecia, variable pigmentation and leukotrichia within radiation fields. All patients were alive at the time of article submission, with overall survival times ranging from 118 to 991 days.
Conclusions and relevance
The results suggest that coarse fractions administered with an SBRT technique is a safe and effective treatment tool for the management of advanced-stage feline solar-induced facial SCCs. These data provide preliminary evidence to support larger, prospective studies evaluating the management of feline facial SCCs with SBRT.</description><subject>Animals</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - veterinary</subject><subject>Cat Diseases - radiotherapy</subject><subject>Cats</subject><subject>Life Sciences & Biomedicine</subject><subject>Original</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Radiosurgery - veterinary</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Veterinary Sciences</subject><issn>1098-612X</issn><issn>1532-2750</issn><issn>1532-2750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNUUuLFDEQDqK46-rdk-QoSGte3Z0-iQy-YEEPCt5CdVI9m6U7mU3SK_PvzTjroILgKUW-R33FR8hTzl5y3vevOBt0x8U3wYdByYHfI-e8laIRfcvu17nCzQE_I49yvmaMDXIQD8mZlB1vdS_PCX72cyw0l9XtKd7CvELxYVs_MGEsYIu3dIwVTOB8xWKg5QoT7PZ0iolOOPuAdALrYab5ZoUlrplanGdqIVkf4gL5MXkwwZzxyd17Qb6-e_tl86G5_PT-4-bNZWOVbEsDauJKqV65UYLqpnFEJwToDlUHruOsVa4m187ZYZCjHgFbnHormBSCcyUvyOuj724dF3QWQ0kwm13yC6S9ieDNn0jwV2Ybbw1nmgveyerw_M4hxZsVczGLz4drIGA9zAg1CKGZVn2lsiPVpphzwum0hzNzqMf8XU-VPPs930nwq49KeHEkfMcxTtl6DBZPtFpgJwVvW1UndrDT_8_e-PKzvk1cQ6nS5ijNsEVzHdcUajH_Tv4DKjC7jQ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Swan, Michaela B</creator><creator>Morrow, Deanna M</creator><creator>Lurie, David M</creator><general>SAGE Publications</general><general>Sage</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0769-4960</orcidid></search><sort><creationdate>20211201</creationdate><title>Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas</title><author>Swan, Michaela B ; Morrow, Deanna M ; Lurie, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-a4f144474db3a46fbbed22a86e46ad61054d3618ddc993b8bae5ef7c203221143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - veterinary</topic><topic>Cat Diseases - radiotherapy</topic><topic>Cats</topic><topic>Life Sciences & Biomedicine</topic><topic>Original</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Radiosurgery - veterinary</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Veterinary Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swan, Michaela B</creatorcontrib><creatorcontrib>Morrow, Deanna M</creatorcontrib><creatorcontrib>Lurie, David M</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of feline medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Swan, Michaela B</au><au>Morrow, Deanna M</au><au>Lurie, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas</atitle><jtitle>Journal of feline medicine and surgery</jtitle><stitle>J FELINE MED SURG</stitle><addtitle>J Feline Med Surg</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>23</volume><issue>12</issue><spage>1081</spage><epage>1088</epage><pages>1081-1088</pages><artnum>1098612</artnum><issn>1098-612X</issn><issn>1532-2750</issn><eissn>1532-2750</eissn><abstract>Objectives
The use of stereotactic body radiation therapy (SBRT) has not been assessed in advanced-stage feline solar-induced facial squamous cell carcinomas (SCCs). The objective of this study was to provide preliminary data on the use and safety profile of coarse fractions administered with an SBRT regime to manage advanced-stage feline solar-induced facial SCCs.
Methods
This retrospective study assessed five cats diagnosed with advanced-stage solar-induced facial SCCs that received SBRT as their primary treatment or, in one cat, following failed surgical intervention. Tumour sites received three fractions totalling 26.25–27 Gy over a 3–5-day period.
Results
All patients developed acute effects following SBRT including alopecia, epilation and erythema. Late effects were mild and included alopecia, variable pigmentation and leukotrichia within radiation fields. All patients were alive at the time of article submission, with overall survival times ranging from 118 to 991 days.
Conclusions and relevance
The results suggest that coarse fractions administered with an SBRT technique is a safe and effective treatment tool for the management of advanced-stage feline solar-induced facial SCCs. These data provide preliminary evidence to support larger, prospective studies evaluating the management of feline facial SCCs with SBRT.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33615873</pmid><doi>10.1177/1098612X21994391</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0769-4960</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of feline medicine and surgery, 2021-12, Vol.23 (12), p.1081-1088, Article 1098612 |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - veterinary Cat Diseases - radiotherapy Cats Life Sciences & Biomedicine Original Pilot Projects Prospective Studies Radiosurgery - veterinary Retrospective Studies Science & Technology Veterinary Sciences |
| title | Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas |
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