Residual Pyramidal Lobe Increases Stimulated Thyroglobulin and Decreases Endogenous Thyroid Stimulating Hormone Stimulation in Differentiated Thyroid Cancer Patients
To determine the frequency of pyramidal lobe remnants after total thyroidectomy (TT) and the effect on stimulated thyroglobulin (Tg). The study included 1740 differentiated thyroid cancer (DTC) patients who were followed up by our center. The department database was searched to identify DTC patients...
Gespeichert in:
| Veröffentlicht in: | Endocrine practice 2021-03, Vol.27 (3), p.212-215 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 215 |
|---|---|
| container_issue | 3 |
| container_start_page | 212 |
| container_title | Endocrine practice |
| container_volume | 27 |
| creator | Sencar, Muhammed Erkam Calapkulu, Murat Sakiz, Davut Unsal, Ilknur Ozturk Cayir, Derya Hepsen, Sema Kus, Arif Kizilgul, Muhammed Ucan, Bekir Ozbek, Mustafa Cakal, Erman |
| description | To determine the frequency of pyramidal lobe remnants after total thyroidectomy (TT) and the effect on stimulated thyroglobulin (Tg).
The study included 1740 differentiated thyroid cancer (DTC) patients who were followed up by our center. The department database was searched to identify DTC patients with residual pyramidal lobe after TT. All postoperative technetium-99m pertechnetate thyroid scintigraphy images were re-evaluated for pyramidal lobe residue. Serum stimulated Tg and thyroid stimulating hormone (TSH) levels measured within the first 6 months after TT were retrieved from the database.
Pyramidal lobe residue was detected in 10.4% of the patients who underwent TT. Evidence of the pyramidal lobe was present on preoperative ultrasonography in 1.6% of the patients with residual pyramidal lobe. Stimulated Tg in patients with pyramidal lobe residue was significantly higher than that in patients without residue (P = .01). Endogenous stimulated TSH in patients with residual pyramidal lobe was significantly lower than that in patients without residue (P = .036). In 5.7% of patients with pyramidal lobe residue, a TSH level of >30 mIU/L was not achieved, which was a significantly higher rate than that in patients without pyramidal lobe residue (P = .034) and is the level required for maximum radioiodine uptake.
Pyramidal lobe residue was found in almost 10% of DTC patients. The pyramidal lobe is often missed on preoperative ultrasonography. Residual pyramidal lobe increased stimulated Tg and decreased endogenous stimulated TSH. Residual pyramidal lobe may complicate the follow-up of DTC patients. |
| doi_str_mv | 10.1016/j.eprac.2020.10.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000631885700007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1530891X2048365X</els_id><sourcerecordid>2494877666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-9aa37294947deca553ad7f72700f31b06383bf7e1ddbfcf4368d9ecafb145dd03</originalsourceid><addsrcrecordid>eNqNkd1u1DAQhSMEoj_wBEjIl0hVFjvO7wUXKC200kpUUCTuLMceL14l9mInoH0g3rOTZru9Q1x5NP7OjM6cJHnD6IpRVr7frmAXpFplNJs7K0rLZ8kpa3ieZjnlz7EuOE3rhv04Sc5i3FIEG1a_TE44L_OiYOw0-fsVotWT7MntPsjBaqzWvgNy41QAGSGSb6Mdpl6OoMndz33wm953U28dkU6TS3jErpz2G3B-igtm9VFp3YZc-zB4B0897wjOuLTGQAA32qcFqGylUxDILXL4F18lL4zsI7w-vOfJ909Xd-11uv7y-ab9uE4VL5oxbaTkVdbkTV5pULIouNSVqbKKUsNZR0te885UwLTujDI5L2vdIGg6lhdaU36evFvm7oL_NUEcxWCjgr6XDtCYyHB0XVVlWSLKF1QFH2MAI3bBDjLsBaNizkdsxUM-Ys5nbmI-qHp7WDB1A-ij5jEQBC4W4A903kSF9hUcMTrPYHVdoCNKK6Tr_6dbOz6cvfWTG1H6YZEC3vO3hSAOcm0DqFFob__p5B6x_sf8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2494877666</pqid></control><display><type>article</type><title>Residual Pyramidal Lobe Increases Stimulated Thyroglobulin and Decreases Endogenous Thyroid Stimulating Hormone Stimulation in Differentiated Thyroid Cancer Patients</title><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Alma/SFX Local Collection</source><creator>Sencar, Muhammed Erkam ; Calapkulu, Murat ; Sakiz, Davut ; Unsal, Ilknur Ozturk ; Cayir, Derya ; Hepsen, Sema ; Kus, Arif ; Kizilgul, Muhammed ; Ucan, Bekir ; Ozbek, Mustafa ; Cakal, Erman</creator><creatorcontrib>Sencar, Muhammed Erkam ; Calapkulu, Murat ; Sakiz, Davut ; Unsal, Ilknur Ozturk ; Cayir, Derya ; Hepsen, Sema ; Kus, Arif ; Kizilgul, Muhammed ; Ucan, Bekir ; Ozbek, Mustafa ; Cakal, Erman</creatorcontrib><description>To determine the frequency of pyramidal lobe remnants after total thyroidectomy (TT) and the effect on stimulated thyroglobulin (Tg).
The study included 1740 differentiated thyroid cancer (DTC) patients who were followed up by our center. The department database was searched to identify DTC patients with residual pyramidal lobe after TT. All postoperative technetium-99m pertechnetate thyroid scintigraphy images were re-evaluated for pyramidal lobe residue. Serum stimulated Tg and thyroid stimulating hormone (TSH) levels measured within the first 6 months after TT were retrieved from the database.
Pyramidal lobe residue was detected in 10.4% of the patients who underwent TT. Evidence of the pyramidal lobe was present on preoperative ultrasonography in 1.6% of the patients with residual pyramidal lobe. Stimulated Tg in patients with pyramidal lobe residue was significantly higher than that in patients without residue (P = .01). Endogenous stimulated TSH in patients with residual pyramidal lobe was significantly lower than that in patients without residue (P = .036). In 5.7% of patients with pyramidal lobe residue, a TSH level of >30 mIU/L was not achieved, which was a significantly higher rate than that in patients without pyramidal lobe residue (P = .034) and is the level required for maximum radioiodine uptake.
Pyramidal lobe residue was found in almost 10% of DTC patients. The pyramidal lobe is often missed on preoperative ultrasonography. Residual pyramidal lobe increased stimulated Tg and decreased endogenous stimulated TSH. Residual pyramidal lobe may complicate the follow-up of DTC patients.</description><identifier>ISSN: 1530-891X</identifier><identifier>EISSN: 1934-2403</identifier><identifier>DOI: 10.1016/j.eprac.2020.10.006</identifier><identifier>PMID: 33645511</identifier><language>eng</language><publisher>SAN DIEGO: Elsevier Inc</publisher><subject>differentiated thyroid cancer ; Endocrinology & Metabolism ; endogenous stimulated TSH ; Humans ; Iodine Radioisotopes ; Life Sciences & Biomedicine ; pyramidal lobe ; Science & Technology ; stimulated thyroglobulin ; Thyroglobulin ; Thyroid Neoplasms - diagnostic imaging ; Thyroid Neoplasms - surgery ; thyroid scintigraphy ; Thyroidectomy ; Thyrotropin</subject><ispartof>Endocrine practice, 2021-03, Vol.27 (3), p.212-215</ispartof><rights>2020 AACE</rights><rights>Copyright © 2020 AACE. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000631885700007</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c359t-9aa37294947deca553ad7f72700f31b06383bf7e1ddbfcf4368d9ecafb145dd03</citedby><cites>FETCH-LOGICAL-c359t-9aa37294947deca553ad7f72700f31b06383bf7e1ddbfcf4368d9ecafb145dd03</cites><orcidid>0000-0002-7756-3210 ; 0000-0001-5581-4886 ; 0000-0002-8375-7409</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929,39262</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33645511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sencar, Muhammed Erkam</creatorcontrib><creatorcontrib>Calapkulu, Murat</creatorcontrib><creatorcontrib>Sakiz, Davut</creatorcontrib><creatorcontrib>Unsal, Ilknur Ozturk</creatorcontrib><creatorcontrib>Cayir, Derya</creatorcontrib><creatorcontrib>Hepsen, Sema</creatorcontrib><creatorcontrib>Kus, Arif</creatorcontrib><creatorcontrib>Kizilgul, Muhammed</creatorcontrib><creatorcontrib>Ucan, Bekir</creatorcontrib><creatorcontrib>Ozbek, Mustafa</creatorcontrib><creatorcontrib>Cakal, Erman</creatorcontrib><title>Residual Pyramidal Lobe Increases Stimulated Thyroglobulin and Decreases Endogenous Thyroid Stimulating Hormone Stimulation in Differentiated Thyroid Cancer Patients</title><title>Endocrine practice</title><addtitle>ENDOCR PRACT</addtitle><addtitle>Endocr Pract</addtitle><description>To determine the frequency of pyramidal lobe remnants after total thyroidectomy (TT) and the effect on stimulated thyroglobulin (Tg).
The study included 1740 differentiated thyroid cancer (DTC) patients who were followed up by our center. The department database was searched to identify DTC patients with residual pyramidal lobe after TT. All postoperative technetium-99m pertechnetate thyroid scintigraphy images were re-evaluated for pyramidal lobe residue. Serum stimulated Tg and thyroid stimulating hormone (TSH) levels measured within the first 6 months after TT were retrieved from the database.
Pyramidal lobe residue was detected in 10.4% of the patients who underwent TT. Evidence of the pyramidal lobe was present on preoperative ultrasonography in 1.6% of the patients with residual pyramidal lobe. Stimulated Tg in patients with pyramidal lobe residue was significantly higher than that in patients without residue (P = .01). Endogenous stimulated TSH in patients with residual pyramidal lobe was significantly lower than that in patients without residue (P = .036). In 5.7% of patients with pyramidal lobe residue, a TSH level of >30 mIU/L was not achieved, which was a significantly higher rate than that in patients without pyramidal lobe residue (P = .034) and is the level required for maximum radioiodine uptake.
Pyramidal lobe residue was found in almost 10% of DTC patients. The pyramidal lobe is often missed on preoperative ultrasonography. Residual pyramidal lobe increased stimulated Tg and decreased endogenous stimulated TSH. Residual pyramidal lobe may complicate the follow-up of DTC patients.</description><subject>differentiated thyroid cancer</subject><subject>Endocrinology & Metabolism</subject><subject>endogenous stimulated TSH</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Life Sciences & Biomedicine</subject><subject>pyramidal lobe</subject><subject>Science & Technology</subject><subject>stimulated thyroglobulin</subject><subject>Thyroglobulin</subject><subject>Thyroid Neoplasms - diagnostic imaging</subject><subject>Thyroid Neoplasms - surgery</subject><subject>thyroid scintigraphy</subject><subject>Thyroidectomy</subject><subject>Thyrotropin</subject><issn>1530-891X</issn><issn>1934-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkd1u1DAQhSMEoj_wBEjIl0hVFjvO7wUXKC200kpUUCTuLMceL14l9mInoH0g3rOTZru9Q1x5NP7OjM6cJHnD6IpRVr7frmAXpFplNJs7K0rLZ8kpa3ieZjnlz7EuOE3rhv04Sc5i3FIEG1a_TE44L_OiYOw0-fsVotWT7MntPsjBaqzWvgNy41QAGSGSb6Mdpl6OoMndz33wm953U28dkU6TS3jErpz2G3B-igtm9VFp3YZc-zB4B0897wjOuLTGQAA32qcFqGylUxDILXL4F18lL4zsI7w-vOfJ909Xd-11uv7y-ab9uE4VL5oxbaTkVdbkTV5pULIouNSVqbKKUsNZR0te885UwLTujDI5L2vdIGg6lhdaU36evFvm7oL_NUEcxWCjgr6XDtCYyHB0XVVlWSLKF1QFH2MAI3bBDjLsBaNizkdsxUM-Ys5nbmI-qHp7WDB1A-ij5jEQBC4W4A903kSF9hUcMTrPYHVdoCNKK6Tr_6dbOz6cvfWTG1H6YZEC3vO3hSAOcm0DqFFob__p5B6x_sf8</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Sencar, Muhammed Erkam</creator><creator>Calapkulu, Murat</creator><creator>Sakiz, Davut</creator><creator>Unsal, Ilknur Ozturk</creator><creator>Cayir, Derya</creator><creator>Hepsen, Sema</creator><creator>Kus, Arif</creator><creator>Kizilgul, Muhammed</creator><creator>Ucan, Bekir</creator><creator>Ozbek, Mustafa</creator><creator>Cakal, Erman</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7756-3210</orcidid><orcidid>https://orcid.org/0000-0001-5581-4886</orcidid><orcidid>https://orcid.org/0000-0002-8375-7409</orcidid></search><sort><creationdate>202103</creationdate><title>Residual Pyramidal Lobe Increases Stimulated Thyroglobulin and Decreases Endogenous Thyroid Stimulating Hormone Stimulation in Differentiated Thyroid Cancer Patients</title><author>Sencar, Muhammed Erkam ; Calapkulu, Murat ; Sakiz, Davut ; Unsal, Ilknur Ozturk ; Cayir, Derya ; Hepsen, Sema ; Kus, Arif ; Kizilgul, Muhammed ; Ucan, Bekir ; Ozbek, Mustafa ; Cakal, Erman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-9aa37294947deca553ad7f72700f31b06383bf7e1ddbfcf4368d9ecafb145dd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>differentiated thyroid cancer</topic><topic>Endocrinology & Metabolism</topic><topic>endogenous stimulated TSH</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Life Sciences & Biomedicine</topic><topic>pyramidal lobe</topic><topic>Science & Technology</topic><topic>stimulated thyroglobulin</topic><topic>Thyroglobulin</topic><topic>Thyroid Neoplasms - diagnostic imaging</topic><topic>Thyroid Neoplasms - surgery</topic><topic>thyroid scintigraphy</topic><topic>Thyroidectomy</topic><topic>Thyrotropin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sencar, Muhammed Erkam</creatorcontrib><creatorcontrib>Calapkulu, Murat</creatorcontrib><creatorcontrib>Sakiz, Davut</creatorcontrib><creatorcontrib>Unsal, Ilknur Ozturk</creatorcontrib><creatorcontrib>Cayir, Derya</creatorcontrib><creatorcontrib>Hepsen, Sema</creatorcontrib><creatorcontrib>Kus, Arif</creatorcontrib><creatorcontrib>Kizilgul, Muhammed</creatorcontrib><creatorcontrib>Ucan, Bekir</creatorcontrib><creatorcontrib>Ozbek, Mustafa</creatorcontrib><creatorcontrib>Cakal, Erman</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sencar, Muhammed Erkam</au><au>Calapkulu, Murat</au><au>Sakiz, Davut</au><au>Unsal, Ilknur Ozturk</au><au>Cayir, Derya</au><au>Hepsen, Sema</au><au>Kus, Arif</au><au>Kizilgul, Muhammed</au><au>Ucan, Bekir</au><au>Ozbek, Mustafa</au><au>Cakal, Erman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Residual Pyramidal Lobe Increases Stimulated Thyroglobulin and Decreases Endogenous Thyroid Stimulating Hormone Stimulation in Differentiated Thyroid Cancer Patients</atitle><jtitle>Endocrine practice</jtitle><stitle>ENDOCR PRACT</stitle><addtitle>Endocr Pract</addtitle><date>2021-03</date><risdate>2021</risdate><volume>27</volume><issue>3</issue><spage>212</spage><epage>215</epage><pages>212-215</pages><issn>1530-891X</issn><eissn>1934-2403</eissn><abstract>To determine the frequency of pyramidal lobe remnants after total thyroidectomy (TT) and the effect on stimulated thyroglobulin (Tg).
The study included 1740 differentiated thyroid cancer (DTC) patients who were followed up by our center. The department database was searched to identify DTC patients with residual pyramidal lobe after TT. All postoperative technetium-99m pertechnetate thyroid scintigraphy images were re-evaluated for pyramidal lobe residue. Serum stimulated Tg and thyroid stimulating hormone (TSH) levels measured within the first 6 months after TT were retrieved from the database.
Pyramidal lobe residue was detected in 10.4% of the patients who underwent TT. Evidence of the pyramidal lobe was present on preoperative ultrasonography in 1.6% of the patients with residual pyramidal lobe. Stimulated Tg in patients with pyramidal lobe residue was significantly higher than that in patients without residue (P = .01). Endogenous stimulated TSH in patients with residual pyramidal lobe was significantly lower than that in patients without residue (P = .036). In 5.7% of patients with pyramidal lobe residue, a TSH level of >30 mIU/L was not achieved, which was a significantly higher rate than that in patients without pyramidal lobe residue (P = .034) and is the level required for maximum radioiodine uptake.
Pyramidal lobe residue was found in almost 10% of DTC patients. The pyramidal lobe is often missed on preoperative ultrasonography. Residual pyramidal lobe increased stimulated Tg and decreased endogenous stimulated TSH. Residual pyramidal lobe may complicate the follow-up of DTC patients.</abstract><cop>SAN DIEGO</cop><pub>Elsevier Inc</pub><pmid>33645511</pmid><doi>10.1016/j.eprac.2020.10.006</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-7756-3210</orcidid><orcidid>https://orcid.org/0000-0001-5581-4886</orcidid><orcidid>https://orcid.org/0000-0002-8375-7409</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-891X |
| ispartof | Endocrine practice, 2021-03, Vol.27 (3), p.212-215 |
| issn | 1530-891X 1934-2403 |
| language | eng |
| recordid | cdi_webofscience_primary_000631885700007 |
| source | MEDLINE; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Alma/SFX Local Collection |
| subjects | differentiated thyroid cancer Endocrinology & Metabolism endogenous stimulated TSH Humans Iodine Radioisotopes Life Sciences & Biomedicine pyramidal lobe Science & Technology stimulated thyroglobulin Thyroglobulin Thyroid Neoplasms - diagnostic imaging Thyroid Neoplasms - surgery thyroid scintigraphy Thyroidectomy Thyrotropin |
| title | Residual Pyramidal Lobe Increases Stimulated Thyroglobulin and Decreases Endogenous Thyroid Stimulating Hormone Stimulation in Differentiated Thyroid Cancer Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T18%3A40%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Residual%20Pyramidal%20Lobe%20Increases%20Stimulated%20Thyroglobulin%20and%20Decreases%20Endogenous%20Thyroid%20Stimulating%20Hormone%20Stimulation%20in%20Differentiated%20Thyroid%20Cancer%20Patients&rft.jtitle=Endocrine%20practice&rft.au=Sencar,%20Muhammed%20Erkam&rft.date=2021-03&rft.volume=27&rft.issue=3&rft.spage=212&rft.epage=215&rft.pages=212-215&rft.issn=1530-891X&rft.eissn=1934-2403&rft_id=info:doi/10.1016/j.eprac.2020.10.006&rft_dat=%3Cproquest_webof%3E2494877666%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2494877666&rft_id=info:pmid/33645511&rft_els_id=S1530891X2048365X&rfr_iscdi=true |