Is GDF-15 level associated with gestational diabetes mellitus and adverse perinatal outcomes?
Growth differentiation factor-15 (GDF-15), the new member of transforming growth factor (TGF)-beta family, is released as a response of oxidative stress, inflammation and tissue injury. We aimed to determine GDF-15 levels in patients with Gestational Diabetes Mellitus (GDM) and the relation between...
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| Veröffentlicht in: | Taiwanese journal of obstetrics & gynecology 2021-03, Vol.60 (2), p.221-224 |
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| container_title | Taiwanese journal of obstetrics & gynecology |
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| creator | Yakut, Kadriye Öcal, Doğa Fatma Öztürk, Filiz Halıcı Öztürk, Merve Oğuz, Yüksel Sınacı, Selcan Çağlar, Turhan |
| description | Growth differentiation factor-15 (GDF-15), the new member of transforming growth factor (TGF)-beta family, is released as a response of oxidative stress, inflammation and tissue injury. We aimed to determine GDF-15 levels in patients with Gestational Diabetes Mellitus (GDM) and the relation between GDF-15 and adverse perinatal outcomes.
Forty pregnant women with GDM (receiving diet and insulin therapy) and forty healthy pregnant women as control group participated in this current study. GDF- 15 levels were analyzed by enzyme-linked immunosorbent assess kit.
The median serum GDF-15 level was measured higher in patients with GDM, and it was statistically meaningful (p: 0.000). Logistic regression analysis indicated that with the increase of GDF-15 level, the risk of GDM diseases increases as well. (P: 0.001, OR = 1.009; 95% CI = 1.003–1.014). There were no differences between GDF-15 levels and perinatal outcomes.
We concluded that higher GDF-15 levels are related to GDM in the third trimester. The optimal GDF-15 cut-off value was measured as 326 pg/ml for the diagnosis of GDM with 70% sensitivity and 60% specificity in our study. Further studies are needed to show the significance of GDF-15 as a biomarker for the disease. |
| doi_str_mv | 10.1016/j.tjog.2020.12.004 |
| format | Article |
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Forty pregnant women with GDM (receiving diet and insulin therapy) and forty healthy pregnant women as control group participated in this current study. GDF- 15 levels were analyzed by enzyme-linked immunosorbent assess kit.
The median serum GDF-15 level was measured higher in patients with GDM, and it was statistically meaningful (p: 0.000). Logistic regression analysis indicated that with the increase of GDF-15 level, the risk of GDM diseases increases as well. (P: 0.001, OR = 1.009; 95% CI = 1.003–1.014). There were no differences between GDF-15 levels and perinatal outcomes.
We concluded that higher GDF-15 levels are related to GDM in the third trimester. The optimal GDF-15 cut-off value was measured as 326 pg/ml for the diagnosis of GDM with 70% sensitivity and 60% specificity in our study. Further studies are needed to show the significance of GDF-15 as a biomarker for the disease.</description><identifier>ISSN: 1028-4559</identifier><identifier>EISSN: 1875-6263</identifier><identifier>DOI: 10.1016/j.tjog.2020.12.004</identifier><identifier>PMID: 33678319</identifier><language>eng</language><publisher>China (Republic : 1949- ): Elsevier B.V</publisher><subject>GDM ; Growth differentiation factor-15 ; Oxidative stress ; Perinatal outcome</subject><ispartof>Taiwanese journal of obstetrics & gynecology, 2021-03, Vol.60 (2), p.221-224</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-b8c69a942a95d0e719a040eb54e59f7d7afba7fa57596a5d44033b5b9e66ce373</citedby><cites>FETCH-LOGICAL-c466t-b8c69a942a95d0e719a040eb54e59f7d7afba7fa57596a5d44033b5b9e66ce373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tjog.2020.12.004$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,2102,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33678319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yakut, Kadriye</creatorcontrib><creatorcontrib>Öcal, Doğa Fatma</creatorcontrib><creatorcontrib>Öztürk, Filiz Halıcı</creatorcontrib><creatorcontrib>Öztürk, Merve</creatorcontrib><creatorcontrib>Oğuz, Yüksel</creatorcontrib><creatorcontrib>Sınacı, Selcan</creatorcontrib><creatorcontrib>Çağlar, Turhan</creatorcontrib><title>Is GDF-15 level associated with gestational diabetes mellitus and adverse perinatal outcomes?</title><title>Taiwanese journal of obstetrics & gynecology</title><addtitle>Taiwan J Obstet Gynecol</addtitle><description>Growth differentiation factor-15 (GDF-15), the new member of transforming growth factor (TGF)-beta family, is released as a response of oxidative stress, inflammation and tissue injury. We aimed to determine GDF-15 levels in patients with Gestational Diabetes Mellitus (GDM) and the relation between GDF-15 and adverse perinatal outcomes.
Forty pregnant women with GDM (receiving diet and insulin therapy) and forty healthy pregnant women as control group participated in this current study. GDF- 15 levels were analyzed by enzyme-linked immunosorbent assess kit.
The median serum GDF-15 level was measured higher in patients with GDM, and it was statistically meaningful (p: 0.000). Logistic regression analysis indicated that with the increase of GDF-15 level, the risk of GDM diseases increases as well. (P: 0.001, OR = 1.009; 95% CI = 1.003–1.014). There were no differences between GDF-15 levels and perinatal outcomes.
We concluded that higher GDF-15 levels are related to GDM in the third trimester. The optimal GDF-15 cut-off value was measured as 326 pg/ml for the diagnosis of GDM with 70% sensitivity and 60% specificity in our study. Further studies are needed to show the significance of GDF-15 as a biomarker for the disease.</description><subject>GDM</subject><subject>Growth differentiation factor-15</subject><subject>Oxidative stress</subject><subject>Perinatal outcome</subject><issn>1028-4559</issn><issn>1875-6263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kF1rFDEUhgex2Fr9A15I_sCs-c4EBJFq60LBm_ayhDPJmTXD7GZJsiv-e7Ou9tKrEw7v-5zwdN07RleMMv1hXtU5bVac8rbgK0rli-6KDUb1mmvxsr0pH3qplL3sXpcyt4ChlL7qLoXQZhDMXnVP60Luvtz2TJEFj7gQKCX5CBUD-RnrD7LBUqHGtIOFhAgjVixki8sS66EQ2AUC4Yi5INljjjuoLZcO1actlk9vuosJloJv_87r7vH268PNt_7--9365vN976XWtR8Hry1YycGqQNEwC1RSHJVEZScTDEwjmAmUUVaDClJSIUY1WtTaozDiulufuSHB7PY5biH_cgmi-7NIeeMg1-gXdAOXw9AOGD4xqQUHwQ2oiQUerODj2Fj8zPI5lZJxeuYx6k7e3exO3t3Ju2PcNa2t9P5c2h_GLYbnyj_RLfDxHMCm4Rgxu-Ij7jyGmNHX9s_4P_5vm6qT1A</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Yakut, Kadriye</creator><creator>Öcal, Doğa Fatma</creator><creator>Öztürk, Filiz Halıcı</creator><creator>Öztürk, Merve</creator><creator>Oğuz, Yüksel</creator><creator>Sınacı, Selcan</creator><creator>Çağlar, Turhan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>202103</creationdate><title>Is GDF-15 level associated with gestational diabetes mellitus and adverse perinatal outcomes?</title><author>Yakut, Kadriye ; Öcal, Doğa Fatma ; Öztürk, Filiz Halıcı ; Öztürk, Merve ; Oğuz, Yüksel ; Sınacı, Selcan ; Çağlar, Turhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-b8c69a942a95d0e719a040eb54e59f7d7afba7fa57596a5d44033b5b9e66ce373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>GDM</topic><topic>Growth differentiation factor-15</topic><topic>Oxidative stress</topic><topic>Perinatal outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yakut, Kadriye</creatorcontrib><creatorcontrib>Öcal, Doğa Fatma</creatorcontrib><creatorcontrib>Öztürk, Filiz Halıcı</creatorcontrib><creatorcontrib>Öztürk, Merve</creatorcontrib><creatorcontrib>Oğuz, Yüksel</creatorcontrib><creatorcontrib>Sınacı, Selcan</creatorcontrib><creatorcontrib>Çağlar, Turhan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Taiwanese journal of obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yakut, Kadriye</au><au>Öcal, Doğa Fatma</au><au>Öztürk, Filiz Halıcı</au><au>Öztürk, Merve</au><au>Oğuz, Yüksel</au><au>Sınacı, Selcan</au><au>Çağlar, Turhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is GDF-15 level associated with gestational diabetes mellitus and adverse perinatal outcomes?</atitle><jtitle>Taiwanese journal of obstetrics & gynecology</jtitle><addtitle>Taiwan J Obstet Gynecol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>60</volume><issue>2</issue><spage>221</spage><epage>224</epage><pages>221-224</pages><issn>1028-4559</issn><eissn>1875-6263</eissn><abstract>Growth differentiation factor-15 (GDF-15), the new member of transforming growth factor (TGF)-beta family, is released as a response of oxidative stress, inflammation and tissue injury. We aimed to determine GDF-15 levels in patients with Gestational Diabetes Mellitus (GDM) and the relation between GDF-15 and adverse perinatal outcomes.
Forty pregnant women with GDM (receiving diet and insulin therapy) and forty healthy pregnant women as control group participated in this current study. GDF- 15 levels were analyzed by enzyme-linked immunosorbent assess kit.
The median serum GDF-15 level was measured higher in patients with GDM, and it was statistically meaningful (p: 0.000). Logistic regression analysis indicated that with the increase of GDF-15 level, the risk of GDM diseases increases as well. (P: 0.001, OR = 1.009; 95% CI = 1.003–1.014). There were no differences between GDF-15 levels and perinatal outcomes.
We concluded that higher GDF-15 levels are related to GDM in the third trimester. The optimal GDF-15 cut-off value was measured as 326 pg/ml for the diagnosis of GDM with 70% sensitivity and 60% specificity in our study. Further studies are needed to show the significance of GDF-15 as a biomarker for the disease.</abstract><cop>China (Republic : 1949- )</cop><pub>Elsevier B.V</pub><pmid>33678319</pmid><doi>10.1016/j.tjog.2020.12.004</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | GDM Growth differentiation factor-15 Oxidative stress Perinatal outcome |
| title | Is GDF-15 level associated with gestational diabetes mellitus and adverse perinatal outcomes? |
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