Serum 25-hydroxyvitamin D concentration and its association with glucose intolerance in an indigenous population
Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consist...
Gespeichert in:
| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-03, Vol.40 (3), p.1318-1322 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1322 |
|---|---|
| container_issue | 3 |
| container_start_page | 1318 |
| container_title | Clinical nutrition (Edinburgh, Scotland) |
| container_volume | 40 |
| creator | Abrahão, Giovanna P. Santos, Marcia C. Vieira Filho, João Paulo B. Dal Fabbro, Amaury L. Franco, Laércio J. Moises, Regina S. |
| description | Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians.
The study population consisted of 819 full Xavante Indians (410 women), aged ≥18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30–100 ng/mL), vitamin D insufficiency (25(OH)D: 20- |
| doi_str_mv | 10.1016/j.clnu.2020.08.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000628912900027CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0261561420304301</els_id><sourcerecordid>2441262037</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-e1d7b539714b132cfccb069c47d98eb176b273a54dfae46d3ef66e3dd2fa27463</originalsourceid><addsrcrecordid>eNqNkV1v1SAYgIlxccfpH_DC9NLEtOOjhTbxxpz5lSzZhXpNKLzdOGmhAt08_37UHndpvAFCnofAA0JvCK4IJvzyUOnRLRXFFFe4rTBpnqEdaRgtSdey52iHKSdlw0l9jl7GeMAYN0y0L9A5o11eE7FD83cIy1TQprw7muB_H-9tUpN1xVWhvdPgUlDJelcoZwqbYqFi9Npuew823RW346J9hMK65EcIKkt5nfk8GnsLzi-xmP28jH-kV-hsUGOE16f5Av38_OnH_mt5ffPl2_7jdalZw1MJxIi-YZ0gdU8Y1YPWPeadroXpWuiJ4D0VTDW1GRTU3DAYOAdmDB0UFTVnF-jddu4c_K8FYpKTjRrGUTnIN5K0rgnlFDORUbqhOvgYAwxyDnZS4SgJlmtpeZBrabmWlriVuXSW3p7OX_oJzJPyN20G2g14gN4PUVvIZZ6w_Becth1ZaUzFPldf6-z94lJW3_-_mukPGw05572FIE-GsQF0ksbbfz3kEZZ3sqI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2441262037</pqid></control><display><type>article</type><title>Serum 25-hydroxyvitamin D concentration and its association with glucose intolerance in an indigenous population</title><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Access via ScienceDirect (Elsevier)</source><creator>Abrahão, Giovanna P. ; Santos, Marcia C. ; Vieira Filho, João Paulo B. ; Dal Fabbro, Amaury L. ; Franco, Laércio J. ; Moises, Regina S.</creator><creatorcontrib>Abrahão, Giovanna P. ; Santos, Marcia C. ; Vieira Filho, João Paulo B. ; Dal Fabbro, Amaury L. ; Franco, Laércio J. ; Moises, Regina S.</creatorcontrib><description>Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians.
The study population consisted of 819 full Xavante Indians (410 women), aged ≥18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30–100 ng/mL), vitamin D insufficiency (25(OH)D: 20- <30 ng/mL) and vitamin D deficiency (25(OH)D: < 20 ng/mL). Multiple logistic regression was performed to identify independent associations between 25(OH)D levels and impaired glucose tolerance or diabetes mellitus.
Analyses stratified by 25(OH)D levels shows that 65.5% of the population had vitamin D deficiency/insufficiency (25(OH)D < 30 ng/mL). 25(OH)D concentrations were lower in individuals with impaired glucose tolerance or diabetes mellitus than in normal glucose tolerant individuals. Multiple logistic regression analysis showed an inverse association between increments of 25(OH)D and presence of diabetes mellitus (OR per 1 ng/mL increase in 25(OH)D: 0.97; 95% confidence interval: 0.95–0.99), or impaired glucose tolerance (OR per 1 ng/mL increase in 25(OH)D: 0.87; 95% confidence interval: 0.85–0.89), in an age, sex, BMI and season of sampling-adjusted model.
The present population-based study found a high prevalence of hypovitaminosis D among Xavante Indians. In this at-risk population of type 2 diabetes, a significant association of higher serum 25(OH)D with a decreased prevalence of diabetes mellitus and impaired glucose tolerance was observed.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2020.08.015</identifier><identifier>PMID: 32900517</identifier><language>eng</language><publisher>EDINBURGH: Elsevier Ltd</publisher><subject>25-Hydroxyvitamin D ; Glucose intolerance ; Indigenous population ; Life Sciences & Biomedicine ; Nutrition & Dietetics ; Science & Technology ; Type 2 diabetes mellitus ; Vitamin D</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2021-03, Vol.40 (3), p.1318-1322</ispartof><rights>2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000628912900027</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c356t-e1d7b539714b132cfccb069c47d98eb176b273a54dfae46d3ef66e3dd2fa27463</citedby><cites>FETCH-LOGICAL-c356t-e1d7b539714b132cfccb069c47d98eb176b273a54dfae46d3ef66e3dd2fa27463</cites><orcidid>0000-0002-9048-068X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2020.08.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32900517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abrahão, Giovanna P.</creatorcontrib><creatorcontrib>Santos, Marcia C.</creatorcontrib><creatorcontrib>Vieira Filho, João Paulo B.</creatorcontrib><creatorcontrib>Dal Fabbro, Amaury L.</creatorcontrib><creatorcontrib>Franco, Laércio J.</creatorcontrib><creatorcontrib>Moises, Regina S.</creatorcontrib><title>Serum 25-hydroxyvitamin D concentration and its association with glucose intolerance in an indigenous population</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>CLIN NUTR</addtitle><addtitle>Clin Nutr</addtitle><description>Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians.
The study population consisted of 819 full Xavante Indians (410 women), aged ≥18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30–100 ng/mL), vitamin D insufficiency (25(OH)D: 20- <30 ng/mL) and vitamin D deficiency (25(OH)D: < 20 ng/mL). Multiple logistic regression was performed to identify independent associations between 25(OH)D levels and impaired glucose tolerance or diabetes mellitus.
Analyses stratified by 25(OH)D levels shows that 65.5% of the population had vitamin D deficiency/insufficiency (25(OH)D < 30 ng/mL). 25(OH)D concentrations were lower in individuals with impaired glucose tolerance or diabetes mellitus than in normal glucose tolerant individuals. Multiple logistic regression analysis showed an inverse association between increments of 25(OH)D and presence of diabetes mellitus (OR per 1 ng/mL increase in 25(OH)D: 0.97; 95% confidence interval: 0.95–0.99), or impaired glucose tolerance (OR per 1 ng/mL increase in 25(OH)D: 0.87; 95% confidence interval: 0.85–0.89), in an age, sex, BMI and season of sampling-adjusted model.
The present population-based study found a high prevalence of hypovitaminosis D among Xavante Indians. In this at-risk population of type 2 diabetes, a significant association of higher serum 25(OH)D with a decreased prevalence of diabetes mellitus and impaired glucose tolerance was observed.</description><subject>25-Hydroxyvitamin D</subject><subject>Glucose intolerance</subject><subject>Indigenous population</subject><subject>Life Sciences & Biomedicine</subject><subject>Nutrition & Dietetics</subject><subject>Science & Technology</subject><subject>Type 2 diabetes mellitus</subject><subject>Vitamin D</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkV1v1SAYgIlxccfpH_DC9NLEtOOjhTbxxpz5lSzZhXpNKLzdOGmhAt08_37UHndpvAFCnofAA0JvCK4IJvzyUOnRLRXFFFe4rTBpnqEdaRgtSdey52iHKSdlw0l9jl7GeMAYN0y0L9A5o11eE7FD83cIy1TQprw7muB_H-9tUpN1xVWhvdPgUlDJelcoZwqbYqFi9Npuew823RW346J9hMK65EcIKkt5nfk8GnsLzi-xmP28jH-kV-hsUGOE16f5Av38_OnH_mt5ffPl2_7jdalZw1MJxIi-YZ0gdU8Y1YPWPeadroXpWuiJ4D0VTDW1GRTU3DAYOAdmDB0UFTVnF-jddu4c_K8FYpKTjRrGUTnIN5K0rgnlFDORUbqhOvgYAwxyDnZS4SgJlmtpeZBrabmWlriVuXSW3p7OX_oJzJPyN20G2g14gN4PUVvIZZ6w_Becth1ZaUzFPldf6-z94lJW3_-_mukPGw05572FIE-GsQF0ksbbfz3kEZZ3sqI</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Abrahão, Giovanna P.</creator><creator>Santos, Marcia C.</creator><creator>Vieira Filho, João Paulo B.</creator><creator>Dal Fabbro, Amaury L.</creator><creator>Franco, Laércio J.</creator><creator>Moises, Regina S.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9048-068X</orcidid></search><sort><creationdate>202103</creationdate><title>Serum 25-hydroxyvitamin D concentration and its association with glucose intolerance in an indigenous population</title><author>Abrahão, Giovanna P. ; Santos, Marcia C. ; Vieira Filho, João Paulo B. ; Dal Fabbro, Amaury L. ; Franco, Laércio J. ; Moises, Regina S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e1d7b539714b132cfccb069c47d98eb176b273a54dfae46d3ef66e3dd2fa27463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Glucose intolerance</topic><topic>Indigenous population</topic><topic>Life Sciences & Biomedicine</topic><topic>Nutrition & Dietetics</topic><topic>Science & Technology</topic><topic>Type 2 diabetes mellitus</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abrahão, Giovanna P.</creatorcontrib><creatorcontrib>Santos, Marcia C.</creatorcontrib><creatorcontrib>Vieira Filho, João Paulo B.</creatorcontrib><creatorcontrib>Dal Fabbro, Amaury L.</creatorcontrib><creatorcontrib>Franco, Laércio J.</creatorcontrib><creatorcontrib>Moises, Regina S.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abrahão, Giovanna P.</au><au>Santos, Marcia C.</au><au>Vieira Filho, João Paulo B.</au><au>Dal Fabbro, Amaury L.</au><au>Franco, Laércio J.</au><au>Moises, Regina S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum 25-hydroxyvitamin D concentration and its association with glucose intolerance in an indigenous population</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><stitle>CLIN NUTR</stitle><addtitle>Clin Nutr</addtitle><date>2021-03</date><risdate>2021</risdate><volume>40</volume><issue>3</issue><spage>1318</spage><epage>1322</epage><pages>1318-1322</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians.
The study population consisted of 819 full Xavante Indians (410 women), aged ≥18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30–100 ng/mL), vitamin D insufficiency (25(OH)D: 20- <30 ng/mL) and vitamin D deficiency (25(OH)D: < 20 ng/mL). Multiple logistic regression was performed to identify independent associations between 25(OH)D levels and impaired glucose tolerance or diabetes mellitus.
Analyses stratified by 25(OH)D levels shows that 65.5% of the population had vitamin D deficiency/insufficiency (25(OH)D < 30 ng/mL). 25(OH)D concentrations were lower in individuals with impaired glucose tolerance or diabetes mellitus than in normal glucose tolerant individuals. Multiple logistic regression analysis showed an inverse association between increments of 25(OH)D and presence of diabetes mellitus (OR per 1 ng/mL increase in 25(OH)D: 0.97; 95% confidence interval: 0.95–0.99), or impaired glucose tolerance (OR per 1 ng/mL increase in 25(OH)D: 0.87; 95% confidence interval: 0.85–0.89), in an age, sex, BMI and season of sampling-adjusted model.
The present population-based study found a high prevalence of hypovitaminosis D among Xavante Indians. In this at-risk population of type 2 diabetes, a significant association of higher serum 25(OH)D with a decreased prevalence of diabetes mellitus and impaired glucose tolerance was observed.</abstract><cop>EDINBURGH</cop><pub>Elsevier Ltd</pub><pmid>32900517</pmid><doi>10.1016/j.clnu.2020.08.015</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9048-068X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2021-03, Vol.40 (3), p.1318-1322 |
| issn | 0261-5614 1532-1983 |
| language | eng |
| recordid | cdi_webofscience_primary_000628912900027CitationCount |
| source | Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Access via ScienceDirect (Elsevier) |
| subjects | 25-Hydroxyvitamin D Glucose intolerance Indigenous population Life Sciences & Biomedicine Nutrition & Dietetics Science & Technology Type 2 diabetes mellitus Vitamin D |
| title | Serum 25-hydroxyvitamin D concentration and its association with glucose intolerance in an indigenous population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-09T21%3A12%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%2025-hydroxyvitamin%20D%20concentration%20and%20its%20association%20with%20glucose%20intolerance%20in%20an%20indigenous%20population&rft.jtitle=Clinical%20nutrition%20(Edinburgh,%20Scotland)&rft.au=Abrah%C3%A3o,%20Giovanna%20P.&rft.date=2021-03&rft.volume=40&rft.issue=3&rft.spage=1318&rft.epage=1322&rft.pages=1318-1322&rft.issn=0261-5614&rft.eissn=1532-1983&rft_id=info:doi/10.1016/j.clnu.2020.08.015&rft_dat=%3Cproquest_webof%3E2441262037%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2441262037&rft_id=info:pmid/32900517&rft_els_id=S0261561420304301&rfr_iscdi=true |