Sex-specific Associations of Sex Hormone Binding Globulin with CKD and Kidney Function: A Univariable and Multivariable Mendelian Randomization Study in the UK Biobank

Background Kidney function declines faster in men. Testosterone levels may mediate the sex disparity. Correspondingly, levels of sex hormone binding globulin (SHBG), which modulates sex hormones, might also be relevant to the lower kidney function in men. The sex-specific role of SHBG is unclear. Me...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2021-03, Vol.32 (3), p.686-694
Hauptverfasser:	Zhao, Jie, Schooling, C. Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - blood Albuminuria - etiology Albuminuria - genetics Biological Specimen Banks Clinical Research Female Genome-Wide Association Study Glomerular Filtration Rate - genetics Humans Life Sciences & Biomedicine Male Mendelian Randomization Analysis Multivariate Analysis Polymorphism, Single Nucleotide Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - genetics Risk Factors Science & Technology Sex Factors Sex Hormone-Binding Globulin - genetics Sex Hormone-Binding Globulin - metabolism Testosterone - blood United Kingdom Urology & Nephrology
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Zusammenfassung:	Background Kidney function declines faster in men. Testosterone levels may mediate the sex disparity. Correspondingly, levels of sex hormone binding globulin (SHBG), which modulates sex hormones, might also be relevant to the lower kidney function in men. The sex-specific role of SHBG is unclear. Methods A sex-specific, Mendelian randomization (MR) study provided unconfounded estimates of SHBG levels among the United Kingdom Biobank population. Univariable MR applied 357 single nucleotide polymorphisms (SNPs) in men and 359 SNPs in women. These published SNPs strongly (P
ISSN:	1046-6673 1533-3450
DOI:	10.1681/ASN.2020050659