Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor
Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, the development of reliable and rapid techno...
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| Veröffentlicht in: | Scientific reports 2021-01, Vol.11 (1), p.1338-14, Article 1338 |
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| description | Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, the development of reliable and rapid technologies for TMAO detection may augment our understanding of pathogenesis and diagnosis of diseases that TMAO has implicated. The present work is the first report on the development of a molecularly imprinted polymer (MIP) based electrochemical sensor for sensitive and selective detection of TMAO in body fluids. The MIP developed was based on the polypyrrole (PPy), which was synthesized via chemical oxidation polymerization method, with and without the presence of TMAO. The MIP, NIP and the non-sonicated polymer (PPy-TMAO) were separately deposited electrophoretically onto the hydrolyzed indium tin oxide (ITO) coated glasses. The chemical, morphological, and electrochemical behavior of MIP, non-imprinted polymer (NIP), and PPy-TMAO were characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and electrochemical techniques. The detection response was recorded using differential pulse voltammetry (DPV), which revealed a decrease in the peak current with the increase in concentration of TMAO. The MIP sensor showed a dynamic detection range of 1–15 ppm with a sensitivity of 2.47 µA mL ppm
−1
cm
−2
. The developed sensor is easy to construct and operate and is also highly selective to detect TMAO in body fluids such as urine. The present research provides a basis for innovative strategies to develop sensors based on MIP to detect other metabolites derived from gut microbiota that are implicated in human health and diseases. |
| doi_str_mv | 10.1038/s41598-020-80122-6 |
| format | Article |
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−1
cm
−2
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−1
cm
−2
. The developed sensor is easy to construct and operate and is also highly selective to detect TMAO in body fluids such as urine. 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B. V. S.</creatorcontrib><creatorcontrib>Yadav, Amit K.</creatorcontrib><creatorcontrib>Mehlawat, Neha</creatorcontrib><creatorcontrib>Jalandra, Rekha</creatorcontrib><creatorcontrib>Solanki, Pratima R.</creatorcontrib><creatorcontrib>Kumar, Anil</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakshmi, G. B. V. S.</au><au>Yadav, Amit K.</au><au>Mehlawat, Neha</au><au>Jalandra, Rekha</au><au>Solanki, Pratima R.</au><au>Kumar, Anil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2021-01-14</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>1338</spage><epage>14</epage><pages>1338-14</pages><artnum>1338</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, the development of reliable and rapid technologies for TMAO detection may augment our understanding of pathogenesis and diagnosis of diseases that TMAO has implicated. The present work is the first report on the development of a molecularly imprinted polymer (MIP) based electrochemical sensor for sensitive and selective detection of TMAO in body fluids. The MIP developed was based on the polypyrrole (PPy), which was synthesized via chemical oxidation polymerization method, with and without the presence of TMAO. The MIP, NIP and the non-sonicated polymer (PPy-TMAO) were separately deposited electrophoretically onto the hydrolyzed indium tin oxide (ITO) coated glasses. The chemical, morphological, and electrochemical behavior of MIP, non-imprinted polymer (NIP), and PPy-TMAO were characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and electrochemical techniques. The detection response was recorded using differential pulse voltammetry (DPV), which revealed a decrease in the peak current with the increase in concentration of TMAO. The MIP sensor showed a dynamic detection range of 1–15 ppm with a sensitivity of 2.47 µA mL ppm
−1
cm
−2
. The developed sensor is easy to construct and operate and is also highly selective to detect TMAO in body fluids such as urine. The present research provides a basis for innovative strategies to develop sensors based on MIP to detect other metabolites derived from gut microbiota that are implicated in human health and diseases.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33446682</pmid><doi>10.1038/s41598-020-80122-6</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8785-6033</orcidid><orcidid>https://orcid.org/0000-0003-1876-0908</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/61 631/67 639/166 639/301 639/925 692/1537 692/308 692/53 692/699 Body fluids Electrochemistry Fourier transforms Gastrointestinal Microbiome Humanities and Social Sciences Humans Infrared spectroscopy Intestinal microflora Limit of Detection Metabolites Methylamines - analysis Microbiota Molecularly Imprinted Polymers - chemistry multidisciplinary Multidisciplinary Sciences Oxidation Pathogenesis Polymers Polymers - chemistry Polypyrroles Scanning electron microscopy Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Sensors Tin Tin oxide Trimethylamine |
| title | Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor |
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