Differential proteomic analysis of children infected with respiratory syncytial virus
Respiratory syncytial virus (RSV) infection is the main cause of lower respiratory tract infection in children. However, there is no effective treatment for RSV infection. Here, we aimed to identify potential biomarkers to aid in the treatment of RSV infection. Children in the acute and convalescenc...
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| Veröffentlicht in: | Brazilian journal of medical and biological research 2021-01, Vol.54 (4), p.e9850-e9850, Article 9850 |
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| creator | Yin, Gen-Quan Zeng, Hui-Xuan Li, Zi-Long Chen, Chen Zhong, Jia-Yong Xiao, Mi-Si Zeng, Qiang Jiang, Wen-Hui Wu, Pei-Qiong Zeng, Jie-Min Hu, Xiao-Yin Chen, Huan-Hui Ruo-Hu Zhao, Hai-Jin Gao, Lin Liu, Cong Cai, Shao-Xi |
| description | Respiratory syncytial virus (RSV) infection is the main cause of lower respiratory tract infection in children. However, there is no effective treatment for RSV infection. Here, we aimed to identify potential biomarkers to aid in the treatment of RSV infection. Children in the acute and convalescence phases of RSV infection were recruited and proteomic analysis was performed to identify differentially expressed proteins (DEPs). Subsequently, promising candidate proteins were determined by functional enrichment and protein-protein interaction network analysis, and underwent further validation by western blot both in clinical and mouse model samples. Among the 79 DEPs identified in RSV patient samples, 4 proteins (BPGM, TPI1, PRDX2, and CFL1) were confirmed to be significantly upregulated during RSV infection. Functional analysis showed that BPGM and TPI1 were mainly involved in glycolysis, indicating an association between RSV infection and the glycolysis metabolic pathway. Our findings provide insights into the proteomic profile during RSV infection and indicated that BPGM, TPI1, PRDX2, and CFL1 may be potential therapeutic biomarkers or targets for the treatment of RSV infection. |
| doi_str_mv | 10.1590/1414-431X20209850 |
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However, there is no effective treatment for RSV infection. Here, we aimed to identify potential biomarkers to aid in the treatment of RSV infection. Children in the acute and convalescence phases of RSV infection were recruited and proteomic analysis was performed to identify differentially expressed proteins (DEPs). Subsequently, promising candidate proteins were determined by functional enrichment and protein-protein interaction network analysis, and underwent further validation by western blot both in clinical and mouse model samples. Among the 79 DEPs identified in RSV patient samples, 4 proteins (BPGM, TPI1, PRDX2, and CFL1) were confirmed to be significantly upregulated during RSV infection. Functional analysis showed that BPGM and TPI1 were mainly involved in glycolysis, indicating an association between RSV infection and the glycolysis metabolic pathway. 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However, there is no effective treatment for RSV infection. Here, we aimed to identify potential biomarkers to aid in the treatment of RSV infection. Children in the acute and convalescence phases of RSV infection were recruited and proteomic analysis was performed to identify differentially expressed proteins (DEPs). Subsequently, promising candidate proteins were determined by functional enrichment and protein-protein interaction network analysis, and underwent further validation by western blot both in clinical and mouse model samples. Among the 79 DEPs identified in RSV patient samples, 4 proteins (BPGM, TPI1, PRDX2, and CFL1) were confirmed to be significantly upregulated during RSV infection. Functional analysis showed that BPGM and TPI1 were mainly involved in glycolysis, indicating an association between RSV infection and the glycolysis metabolic pathway. Our findings provide insights into the proteomic profile during RSV infection and indicated that BPGM, TPI1, PRDX2, and CFL1 may be potential therapeutic biomarkers or targets for the treatment of RSV infection.</description><subject>BIOLOGY</subject><subject>Biomarkers</subject><subject>Child</subject><subject>Children</subject><subject>Differentially expressed protein</subject><subject>Humans</subject><subject>Infection</subject><subject>Life Sciences & Biomedicine</subject><subject>Life Sciences & Biomedicine - Other Topics</subject><subject>MEDICINE, RESEARCH & EXPERIMENTAL</subject><subject>Mouse model</subject><subject>Protein-protein interactions</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Research & Experimental Medicine</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections</subject><subject>Respiratory Syncytial Virus, Human</subject><subject>Science & Technology</subject><issn>0100-879X</issn><issn>1414-431X</issn><issn>1414-431X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl9rFDEUxQdRbK1-AF9kQBBBtt5kkszOi1DWf4WCD1roW8hkbnazZCdrkmndb29mp127b5KHhJvfOeSe3KJ4TeCc8AY-EkbYjFXkhgKFZs7hSXF6qD0tToEAzOZ1c3NSvIhxDUA5MPK8OKkqwQVwcVpcf7bGYMA-WeXKbfAJ_cbqUvXK7aKNpTelXlnXZaS0vUGdsCvvbFqVAePWBpV82JVx1-vd3uLWhiG-LJ4Z5SK-ut_PiuuvX34tvs-ufny7XFxczbQAmmZtYyrOKe3yUzpTmYZC3ljNGK1AIaMGkGNrmooIpo0ignStMMSYFiradtVZcTn5dl6t5TbYjQo76ZWV-4IPS6lCstqhBFIjEI6cdMhy94oACoC2ZkQhCJW9zievqC06L9d-CDmEKH-OMcoxxhxzPgIDENBkwadJsB3aDXY6ZxiUO3rF8U1vV3Lpb2XdkLreG7y_Nwj-94AxyY2NGp1TPfohSsoaQRklFcno2wldqtxL_gefHfWIywvBOcznvBH_Wjii8uow_6nv0dhcPxK8eyRYoXJpFb0bkvV9PAbJBOrgYwxoDm0SkOMsynHuZJ67Pw-zmDVvHudzUDwMXwY-TMAdtt6MsfcaD1gOWlBBm5rmE4wRzP-fXtikxiYWfuhT9RdNsfd4</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Yin, Gen-Quan</creator><creator>Zeng, Hui-Xuan</creator><creator>Li, Zi-Long</creator><creator>Chen, Chen</creator><creator>Zhong, Jia-Yong</creator><creator>Xiao, Mi-Si</creator><creator>Zeng, Qiang</creator><creator>Jiang, Wen-Hui</creator><creator>Wu, Pei-Qiong</creator><creator>Zeng, Jie-Min</creator><creator>Hu, Xiao-Yin</creator><creator>Chen, Huan-Hui</creator><creator>Ruo-Hu</creator><creator>Zhao, Hai-Jin</creator><creator>Gao, Lin</creator><creator>Liu, Cong</creator><creator>Cai, Shao-Xi</creator><general>Assoc Bras Divulg Cientifica</general><general>Associacao Brasileira de Divulgacao Cientifica (ABDC)</general><general>Associação Brasileira de Divulgação Científica</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>INF</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2533-9778</orcidid><orcidid>https://orcid.org/0000-0002-5656-9525</orcidid><orcidid>https://orcid.org/0000-0002-3515-4312</orcidid><orcidid>https://orcid.org/0000-0001-6492-3187</orcidid><orcidid>https://orcid.org/0000-0003-2812-8914</orcidid><orcidid>https://orcid.org/0000-0003-0859-4790</orcidid><orcidid>https://orcid.org/0000-0003-2425-5334</orcidid><orcidid>https://orcid.org/0000-0003-3302-6912</orcidid><orcidid>https://orcid.org/0000-0002-1786-3617</orcidid><orcidid>https://orcid.org/0000-0001-6258-7888</orcidid><orcidid>https://orcid.org/0000-0003-1632-3595</orcidid><orcidid>https://orcid.org/0000-0002-7636-0999</orcidid><orcidid>https://orcid.org/0000-0001-7176-2238</orcidid><orcidid>https://orcid.org/0000-0002-4831-3327</orcidid><orcidid>https://orcid.org/0000-0001-7191-6110</orcidid><orcidid>https://orcid.org/0000-0001-9357-1117</orcidid><orcidid>https://orcid.org/0000-0001-9939-7893</orcidid></search><sort><creationdate>20210101</creationdate><title>Differential proteomic analysis of children infected with respiratory syncytial virus</title><author>Yin, Gen-Quan ; Zeng, Hui-Xuan ; Li, Zi-Long ; Chen, Chen ; Zhong, Jia-Yong ; Xiao, Mi-Si ; Zeng, Qiang ; Jiang, Wen-Hui ; Wu, Pei-Qiong ; Zeng, Jie-Min ; Hu, Xiao-Yin ; Chen, Huan-Hui ; Ruo-Hu ; Zhao, Hai-Jin ; Gao, Lin ; Liu, Cong ; Cai, Shao-Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-b9f35522d056df3f920df34744230ae42f0e5ebf93164cfa161db6f1ffb032bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>BIOLOGY</topic><topic>Biomarkers</topic><topic>Child</topic><topic>Children</topic><topic>Differentially expressed protein</topic><topic>Humans</topic><topic>Infection</topic><topic>Life Sciences & Biomedicine</topic><topic>Life Sciences & Biomedicine - Other Topics</topic><topic>MEDICINE, RESEARCH & EXPERIMENTAL</topic><topic>Mouse model</topic><topic>Protein-protein interactions</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Research & Experimental Medicine</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections</topic><topic>Respiratory Syncytial Virus, Human</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Gen-Quan</creatorcontrib><creatorcontrib>Zeng, Hui-Xuan</creatorcontrib><creatorcontrib>Li, Zi-Long</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Zhong, Jia-Yong</creatorcontrib><creatorcontrib>Xiao, Mi-Si</creatorcontrib><creatorcontrib>Zeng, Qiang</creatorcontrib><creatorcontrib>Jiang, Wen-Hui</creatorcontrib><creatorcontrib>Wu, Pei-Qiong</creatorcontrib><creatorcontrib>Zeng, Jie-Min</creatorcontrib><creatorcontrib>Hu, Xiao-Yin</creatorcontrib><creatorcontrib>Chen, Huan-Hui</creatorcontrib><creatorcontrib>Ruo-Hu</creatorcontrib><creatorcontrib>Zhao, Hai-Jin</creatorcontrib><creatorcontrib>Gao, Lin</creatorcontrib><creatorcontrib>Liu, Cong</creatorcontrib><creatorcontrib>Cai, Shao-Xi</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale OneFile: Informe Academico</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Brazilian journal of medical and biological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Gen-Quan</au><au>Zeng, Hui-Xuan</au><au>Li, Zi-Long</au><au>Chen, Chen</au><au>Zhong, Jia-Yong</au><au>Xiao, Mi-Si</au><au>Zeng, Qiang</au><au>Jiang, Wen-Hui</au><au>Wu, Pei-Qiong</au><au>Zeng, Jie-Min</au><au>Hu, Xiao-Yin</au><au>Chen, Huan-Hui</au><au>Ruo-Hu</au><au>Zhao, Hai-Jin</au><au>Gao, Lin</au><au>Liu, Cong</au><au>Cai, Shao-Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential proteomic analysis of children infected with respiratory syncytial virus</atitle><jtitle>Brazilian journal of medical and biological research</jtitle><stitle>BRAZ J MED BIOL RES</stitle><addtitle>Braz J Med Biol Res</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>54</volume><issue>4</issue><spage>e9850</spage><epage>e9850</epage><pages>e9850-e9850</pages><artnum>9850</artnum><issn>0100-879X</issn><issn>1414-431X</issn><eissn>1414-431X</eissn><abstract>Respiratory syncytial virus (RSV) infection is the main cause of lower respiratory tract infection in children. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | BIOLOGY Biomarkers Child Children Differentially expressed protein Humans Infection Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics MEDICINE, RESEARCH & EXPERIMENTAL Mouse model Protein-protein interactions Proteins Proteomics Research & Experimental Medicine Respiratory syncytial virus Respiratory Syncytial Virus Infections Respiratory Syncytial Virus, Human Science & Technology |
| title | Differential proteomic analysis of children infected with respiratory syncytial virus |
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