Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance

Triple-negative breast cancer (TNBCs) account for 15–20% of all breast cancers and represent the most aggressive subtype of this malignancy. Early tumor relapse and progression are linked to the enrichment of a sub-fraction of cancer cells, termed breast tumor-initiating cells (BTICs), that undergo...

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Veröffentlicht in:	Oncogene 2021-04, Vol.40 (14), p.2509-2523
Hauptverfasser:	Jalalirad, Mohammad, Haddad, Tufia C., Salisbury, Jeffrey L., Radisky, Derek, Zhang, Minzhi, Schroeder, Mark, Tuma, Ann, Leof, Eduard, Carter, Jodi M., Degnim, Amy C., Boughey, Judy C., Sarkaria, Jann, Yu, Jia, Wang, Liewei, Liu, Minetta C., Zammataro, Luca, Malatino, Lorenzo, Galanis, Evanthia, Ingle, James N., Goetz, Matthew P., D’Assoro, Antonino B.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/31 14/19 42/41 631/67/1347 631/80/86/2363 82/80 96/100 Apoptosis Aurora Kinase A - metabolism Biochemistry & Molecular Biology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - mortality Cell Biology Cell Plasticity - genetics Chemoresistance Chemotherapy Drug resistance Female Genetics & Heredity Human Genetics Humans Internal Medicine Kinases Life Sciences & Biomedicine Malignancy Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Oncology Phenotypes Plasticity Science & Technology Signal Transduction Snail protein Survival Analysis
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