SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon
SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolution...
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| Veröffentlicht in: | Scientific reports 2021-02, Vol.11 (1), p.3770-3770, Article 3770 |
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| creator | Botelho-Souza, Luan Felipo Nogueira-Lima, Felipe Souza Roca, Tárcio Peixoto Naveca, Felipe Gomes de Oliveria dos Santos, Alcione Maia, Adriana Cristina Salvador da Silva, Cicileia Correia de Melo Mendonça, Aline Linhares Ferreira Lugtenburg, Celina Aparecida Bertoni Azzi, Camila Flávia Gomes Fontes, Juliana Loca Furtado Cavalcante, Suelen de Cássia Pontello Rampazzo, Rita Santos, Caio Henrique Nemeth Di Sabatino Guimarães, Alice Paula Máximo, Fernando Rodrigues Villalobos-Salcedo, Juan Miguel Vieira, Deusilene Souza |
| description | SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolutionary history of epidemic spread and genetic aspects of strains isolated on the Western Amazon, in the State of Rondônia, Brazil. It was possible to detect a total of 22 mutations. Some of these alterations may possibly be related to effects on transmissibility, the fidelity of RNA replication, the ability of cancer patients to respond to infection, beyond a mutation that emerged after the introduction of SARS-CoV-2 in Rondônia. At least two events of introduction were detected, corresponding to the B.1 and B.1.1 European lineages. An introduction was observed possibly through Argentina, where strains originated that circulated in the Minas Gerais and Ceará Brazilian states, prior to Rondônia (B.1.), as well as through the Minas Gerais state and the Federal District, which gave rise to strains that spread to Rondônia, from the capital to more rural parts of the state (B.1.1.). The findings show the need to monitor the genetic epidemiology of COVID-19, in order to surveil the virus’s evolution, dispersion and diversity. |
| doi_str_mv | 10.1038/s41598-021-83203-2 |
| format | Article |
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The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolutionary history of epidemic spread and genetic aspects of strains isolated on the Western Amazon, in the State of Rondônia, Brazil. It was possible to detect a total of 22 mutations. Some of these alterations may possibly be related to effects on transmissibility, the fidelity of RNA replication, the ability of cancer patients to respond to infection, beyond a mutation that emerged after the introduction of SARS-CoV-2 in Rondônia. At least two events of introduction were detected, corresponding to the B.1 and B.1.1 European lineages. An introduction was observed possibly through Argentina, where strains originated that circulated in the Minas Gerais and Ceará Brazilian states, prior to Rondônia (B.1.), as well as through the Minas Gerais state and the Federal District, which gave rise to strains that spread to Rondônia, from the capital to more rural parts of the state (B.1.1.). 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| recordid | cdi_webofscience_primary_000620252500012 |
| source | Nature Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central; Springer Nature OA/Free Journals; Free Full-Text Journals in Chemistry |
| subjects | 631/114 631/337 Brazil COVID-19 COVID-19 - epidemiology COVID-19 - virology Epidemiology Humanities and Social Sciences Humans multidisciplinary Multidisciplinary Sciences Mutation Mutation Rate Pandemics Phylogeny Ribonucleic acid RNA SARS-CoV-2 - classification SARS-CoV-2 - genetics SARS-CoV-2 - isolation & purification Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Strains (organisms) Viral Proteins - genetics |
| title | SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T02%3A35%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SARS-CoV-2%20genomic%20surveillance%20in%20Rond%C3%B4nia,%20Brazilian%20Western%20Amazon&rft.jtitle=Scientific%20reports&rft.au=Botelho-Souza,%20Luan%20Felipo&rft.date=2021-02-12&rft.volume=11&rft.issue=1&rft.spage=3770&rft.epage=3770&rft.pages=3770-3770&rft.artnum=3770&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-021-83203-2&rft_dat=%3Cproquest_webof%3E2489265506%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2488776274&rft_id=info:pmid/33580111&rft_doaj_id=oai_doaj_org_article_a8ca82f53cbf4ece8e4ab7ebb1c7a612&rfr_iscdi=true |