Mechanism of Intestinal Flora and Proteomics on Regulating Immune Function of Durio zibethinus Rind Polysaccharide

Mechanism of Intestinal Flora and Proteomics on Regulating Immune Function of Durio zibethinus Rind Polysaccharide

In this study, cyclophosphamide was injected intraperitoneally to establish an immunosuppressive mouse model to study the immune regulating effects of Durio zibethinus Murr rind polysaccharide (DZMP) through proteomics and intestinal flora. The results showed that the thymus and spleen indexes of th...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1)
Hauptverfasser: Jiang, Huimin, Wang, Jinmei, Liang, Qiongxin, Jiang, Shengjun, Ma, Changyang, Zhang, Yan, Kang, Wenyi
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants
Bacteria
Cancer therapies
Chemotherapy
Drug dosages
Gene expression
Immune system
Laboratory animals
Metabolism
Metabolites
Pharmaceuticals
Protein expression
Proteins
Proteomics
Spleen
Thymus gland
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Zusammenfassung:In this study, cyclophosphamide was injected intraperitoneally to establish an immunosuppressive mouse model to study the immune regulating effects of Durio zibethinus Murr rind polysaccharide (DZMP) through proteomics and intestinal flora. The results showed that the thymus and spleen indexes of the high-dose DZMP (200 mg/kg) group were significantly increased, and the tissue structure of the spleen was improved compared with the model group (P
ISSN:1942-0900
1942-0994
DOI:10.1155/2021/6614028