Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors
The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription factors integrates nutritional and growth signals to the regulation of metabolism and cell growth in the liver, and deregula...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2021-03, Vol.70 (3), p.653-664 |
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| container_title | Diabetes (New York, N.Y.) |
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| creator | Cui, Aoyuan Ding, Dong Li, Yu |
| description | The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription factors integrates nutritional and growth signals to the regulation of metabolism and cell growth in the liver, and deregulated ATF/CREB family signaling is implicated in the progression of type 2 diabetes, nonalcoholic fatty liver disease, and cancer. This article focuses on the roles of the ATF/CREB family in the regulation of glucose and lipid metabolism and cell growth and its importance in liver physiology. We also highlight how the disrupted ATF/CREB network contributes to human diseases and discuss the perspectives of therapeutically targeting ATF/CREB members in the clinic. |
| doi_str_mv | 10.2337/dbi20-0006 |
| format | Article |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Cell growth Cyclic AMP response element-binding protein Diabetes Diabetes mellitus (non-insulin dependent) Fatty liver Glucose metabolism Hepatocytes Homeostasis Lipid metabolism Liver Liver cancer Liver diseases Metabolism s in Diabetes Transcription factors |
| title | Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors |
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