The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk
Introduction Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis. Aim We assessed the prognostic role of SUA in patients with and without MS. Methods We used data from the multicentre Uric Acid Right for H...
Gespeichert in:
| Veröffentlicht in: | Clinical research in cardiology 2021-07, Vol.110 (7), p.1073-1082 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1082 |
|---|---|
| container_issue | 7 |
| container_start_page | 1073 |
| container_title | Clinical research in cardiology |
| container_volume | 110 |
| creator | Pugliese, Nicola Riccardo Mengozzi, Alessandro Virdis, Agostino Casiglia, Edoardo Tikhonoff, Valerie Cicero, Arrigo F. G. Ungar, Andrea Rivasi, Giulia Salvetti, Massimo Barbagallo, Carlo M. Bombelli, Michele Dell’Oro, Raffaella Bruno, Berardino Lippa, Luciano D’Elia, Lanfranco Verdecchia, Paolo Mallamaci, Francesca Cirillo, Massimo Rattazzi, Marcello Cirillo, Pietro Gesualdo, Loreto Mazza, Alberto Giannattasio, Cristina Maloberti, Alessandro Volpe, Massimo Tocci, Giuliano Georgiopoulos, Georgios Iaccarino, Guido Nazzaro, Pietro Parati, Gianfranco Palatini, Paolo Galletti, Ferruccio Ferri, Claudio Desideri, Giovambattista Viazzi, Francesca Pontremoli, Roberto Muiesan, Maria Lorenza Grassi, Guido Masi, Stefano Borghi, Claudio |
| description | Introduction
Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis.
Aim
We assessed the prognostic role of SUA in patients with and without MS.
Methods
We used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure.
Results
A total of 9589 subjects (median age 58.5 years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median follow-up of 142 months, we observed 558 events. Using a previously validated cardiovascular SUA cut-off to predict CVM (> 5.1 mg/dL in women and 5.6 mg/dL in men), elevated SUA levels were significantly associated to a worse outcome in patients with and without MS (all
p
|
| doi_str_mv | 10.1007/s00392-021-01815-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000619380100001CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2545795738</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-d96423c50ea75a25cfc847820c68d6e78b61520a4f293c0c3957db184aadbf083</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhSNERZ9_gAWKxBIFrp9xNkhoBAWpEpt2bTm2M-OS2IPttJp_j0PKABvEyq_vnHOtU1UvEbxFAO27BEA63ABGDSCBWAPPqjMkeDnyDj8_7gU9rc5TugdgCAh9UZ0SwoG2GJ9V4XZnazftQ8zKa1uHoXZej7NxflvP0elaaWfKXZ0LaOzgvMsu-AWcbFZ9GAuTDt7EMNn6cWd9rVKyKS0Gi2ZarEeXD3V06dtldTKoMdmrp_Wiuvv08Xbzubn5ev1l8-Gm0YxCbkzHKSaagVUtU5jpQQvaCgyaC8NtK3qOGAZFB9wRDZp0rDU9ElQp0w8gyEX1fvXdz_1kjbY-RzXKfXSTigcZlJN_v3i3k9vwIAUmgndtMXj9ZBDD99mmLO_DHH2ZWWJGWVsCyRKDV0rHkFK0wzEBgVxKkmtJspQkf5YkoYhe_TnbUfKrlQKIFXi0fRiSdrZUc8QAgKOOCCj-AGjjsloa2YTZ5yJ98__SQpOVToXwWxt_f_If8_8A_I6_3A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545795738</pqid></control><display><type>article</type><title>The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk</title><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>SpringerLink Journals - AutoHoldings</source><creator>Pugliese, Nicola Riccardo ; Mengozzi, Alessandro ; Virdis, Agostino ; Casiglia, Edoardo ; Tikhonoff, Valerie ; Cicero, Arrigo F. G. ; Ungar, Andrea ; Rivasi, Giulia ; Salvetti, Massimo ; Barbagallo, Carlo M. ; Bombelli, Michele ; Dell’Oro, Raffaella ; Bruno, Berardino ; Lippa, Luciano ; D’Elia, Lanfranco ; Verdecchia, Paolo ; Mallamaci, Francesca ; Cirillo, Massimo ; Rattazzi, Marcello ; Cirillo, Pietro ; Gesualdo, Loreto ; Mazza, Alberto ; Giannattasio, Cristina ; Maloberti, Alessandro ; Volpe, Massimo ; Tocci, Giuliano ; Georgiopoulos, Georgios ; Iaccarino, Guido ; Nazzaro, Pietro ; Parati, Gianfranco ; Palatini, Paolo ; Galletti, Ferruccio ; Ferri, Claudio ; Desideri, Giovambattista ; Viazzi, Francesca ; Pontremoli, Roberto ; Muiesan, Maria Lorenza ; Grassi, Guido ; Masi, Stefano ; Borghi, Claudio</creator><creatorcontrib>Pugliese, Nicola Riccardo ; Mengozzi, Alessandro ; Virdis, Agostino ; Casiglia, Edoardo ; Tikhonoff, Valerie ; Cicero, Arrigo F. G. ; Ungar, Andrea ; Rivasi, Giulia ; Salvetti, Massimo ; Barbagallo, Carlo M. ; Bombelli, Michele ; Dell’Oro, Raffaella ; Bruno, Berardino ; Lippa, Luciano ; D’Elia, Lanfranco ; Verdecchia, Paolo ; Mallamaci, Francesca ; Cirillo, Massimo ; Rattazzi, Marcello ; Cirillo, Pietro ; Gesualdo, Loreto ; Mazza, Alberto ; Giannattasio, Cristina ; Maloberti, Alessandro ; Volpe, Massimo ; Tocci, Giuliano ; Georgiopoulos, Georgios ; Iaccarino, Guido ; Nazzaro, Pietro ; Parati, Gianfranco ; Palatini, Paolo ; Galletti, Ferruccio ; Ferri, Claudio ; Desideri, Giovambattista ; Viazzi, Francesca ; Pontremoli, Roberto ; Muiesan, Maria Lorenza ; Grassi, Guido ; Masi, Stefano ; Borghi, Claudio ; Working Grp Uri ; Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension ; The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension</creatorcontrib><description>Introduction
Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis.
Aim
We assessed the prognostic role of SUA in patients with and without MS.
Methods
We used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure.
Results
A total of 9589 subjects (median age 58.5 years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median follow-up of 142 months, we observed 558 events. Using a previously validated cardiovascular SUA cut-off to predict CVM (> 5.1 mg/dL in women and 5.6 mg/dL in men), elevated SUA levels were significantly associated to a worse outcome in patients with and without MS (all
p
< 0.0001) and provided a significant net reclassification improvement of 7.1% over the diagnosis of MS for CVM (
p
= 0.004). Cox regression analyses identified an independent association between SUA and CVM (Hazard Ratio: 1.79 [95% CI, 1.15–2.79];
p
< 0.0001) after the adjustment for MS, its single components and renal function. Three specific combinations of the MS components were associated with higher CVM when increasing SUA levels were reported, and systemic hypertension was the only individual component ever-present (all
p
< 0.0001).
Conclusion
Increasing SUA levels are associated with a higher CVM risk irrespective of the presence of MS: a cardiovascular SUA threshold may improve risk stratification.
Graphic abstract</description><identifier>ISSN: 1861-0684</identifier><identifier>EISSN: 1861-0692</identifier><identifier>DOI: 10.1007/s00392-021-01815-0</identifier><identifier>PMID: 33604722</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cardiac & Cardiovascular Systems ; Cardiology ; Cardiovascular diseases ; Cardiovascular System & Cardiology ; Cerebral infarction ; Congestive heart failure ; Diagnosis ; Hypertension ; Life Sciences & Biomedicine ; Medicine ; Medicine & Public Health ; Men ; Metabolic disorders ; Metabolic syndrome ; Mortality ; Myocardial infarction ; Original Paper ; Reclassification ; Renal function ; Risk ; Science & Technology ; Uric acid</subject><ispartof>Clinical research in cardiology, 2021-07, Vol.110 (7), p.1073-1082</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>33</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000619380100001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c540t-d96423c50ea75a25cfc847820c68d6e78b61520a4f293c0c3957db184aadbf083</citedby><cites>FETCH-LOGICAL-c540t-d96423c50ea75a25cfc847820c68d6e78b61520a4f293c0c3957db184aadbf083</cites><orcidid>0000-0002-5473-227X ; 0000-0003-2834-9725 ; 0000-0002-4367-3884 ; 0000-0002-4007-9441 ; 0000-0002-0635-4921 ; 0000-0002-4274-8709 ; 0000-0001-7846-0101 ; 0000-0003-4164-6978 ; 0000-0003-4219-7043 ; 0000-0001-9402-7439</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00392-021-01815-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00392-021-01815-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,782,786,887,27931,27932,39265,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33604722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pugliese, Nicola Riccardo</creatorcontrib><creatorcontrib>Mengozzi, Alessandro</creatorcontrib><creatorcontrib>Virdis, Agostino</creatorcontrib><creatorcontrib>Casiglia, Edoardo</creatorcontrib><creatorcontrib>Tikhonoff, Valerie</creatorcontrib><creatorcontrib>Cicero, Arrigo F. G.</creatorcontrib><creatorcontrib>Ungar, Andrea</creatorcontrib><creatorcontrib>Rivasi, Giulia</creatorcontrib><creatorcontrib>Salvetti, Massimo</creatorcontrib><creatorcontrib>Barbagallo, Carlo M.</creatorcontrib><creatorcontrib>Bombelli, Michele</creatorcontrib><creatorcontrib>Dell’Oro, Raffaella</creatorcontrib><creatorcontrib>Bruno, Berardino</creatorcontrib><creatorcontrib>Lippa, Luciano</creatorcontrib><creatorcontrib>D’Elia, Lanfranco</creatorcontrib><creatorcontrib>Verdecchia, Paolo</creatorcontrib><creatorcontrib>Mallamaci, Francesca</creatorcontrib><creatorcontrib>Cirillo, Massimo</creatorcontrib><creatorcontrib>Rattazzi, Marcello</creatorcontrib><creatorcontrib>Cirillo, Pietro</creatorcontrib><creatorcontrib>Gesualdo, Loreto</creatorcontrib><creatorcontrib>Mazza, Alberto</creatorcontrib><creatorcontrib>Giannattasio, Cristina</creatorcontrib><creatorcontrib>Maloberti, Alessandro</creatorcontrib><creatorcontrib>Volpe, Massimo</creatorcontrib><creatorcontrib>Tocci, Giuliano</creatorcontrib><creatorcontrib>Georgiopoulos, Georgios</creatorcontrib><creatorcontrib>Iaccarino, Guido</creatorcontrib><creatorcontrib>Nazzaro, Pietro</creatorcontrib><creatorcontrib>Parati, Gianfranco</creatorcontrib><creatorcontrib>Palatini, Paolo</creatorcontrib><creatorcontrib>Galletti, Ferruccio</creatorcontrib><creatorcontrib>Ferri, Claudio</creatorcontrib><creatorcontrib>Desideri, Giovambattista</creatorcontrib><creatorcontrib>Viazzi, Francesca</creatorcontrib><creatorcontrib>Pontremoli, Roberto</creatorcontrib><creatorcontrib>Muiesan, Maria Lorenza</creatorcontrib><creatorcontrib>Grassi, Guido</creatorcontrib><creatorcontrib>Masi, Stefano</creatorcontrib><creatorcontrib>Borghi, Claudio</creatorcontrib><creatorcontrib>Working Grp Uri</creatorcontrib><creatorcontrib>Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension</creatorcontrib><creatorcontrib>The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension</creatorcontrib><title>The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk</title><title>Clinical research in cardiology</title><addtitle>Clin Res Cardiol</addtitle><addtitle>CLIN RES CARDIOL</addtitle><addtitle>Clin Res Cardiol</addtitle><description>Introduction
Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis.
Aim
We assessed the prognostic role of SUA in patients with and without MS.
Methods
We used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure.
Results
A total of 9589 subjects (median age 58.5 years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median follow-up of 142 months, we observed 558 events. Using a previously validated cardiovascular SUA cut-off to predict CVM (> 5.1 mg/dL in women and 5.6 mg/dL in men), elevated SUA levels were significantly associated to a worse outcome in patients with and without MS (all
p
< 0.0001) and provided a significant net reclassification improvement of 7.1% over the diagnosis of MS for CVM (
p
= 0.004). Cox regression analyses identified an independent association between SUA and CVM (Hazard Ratio: 1.79 [95% CI, 1.15–2.79];
p
< 0.0001) after the adjustment for MS, its single components and renal function. Three specific combinations of the MS components were associated with higher CVM when increasing SUA levels were reported, and systemic hypertension was the only individual component ever-present (all
p
< 0.0001).
Conclusion
Increasing SUA levels are associated with a higher CVM risk irrespective of the presence of MS: a cardiovascular SUA threshold may improve risk stratification.
Graphic abstract</description><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular System & Cardiology</subject><subject>Cerebral infarction</subject><subject>Congestive heart failure</subject><subject>Diagnosis</subject><subject>Hypertension</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Men</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Original Paper</subject><subject>Reclassification</subject><subject>Renal function</subject><subject>Risk</subject><subject>Science & Technology</subject><subject>Uric acid</subject><issn>1861-0684</issn><issn>1861-0692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUtv1DAUhSNERZ9_gAWKxBIFrp9xNkhoBAWpEpt2bTm2M-OS2IPttJp_j0PKABvEyq_vnHOtU1UvEbxFAO27BEA63ABGDSCBWAPPqjMkeDnyDj8_7gU9rc5TugdgCAh9UZ0SwoG2GJ9V4XZnazftQ8zKa1uHoXZej7NxflvP0elaaWfKXZ0LaOzgvMsu-AWcbFZ9GAuTDt7EMNn6cWd9rVKyKS0Gi2ZarEeXD3V06dtldTKoMdmrp_Wiuvv08Xbzubn5ev1l8-Gm0YxCbkzHKSaagVUtU5jpQQvaCgyaC8NtK3qOGAZFB9wRDZp0rDU9ElQp0w8gyEX1fvXdz_1kjbY-RzXKfXSTigcZlJN_v3i3k9vwIAUmgndtMXj9ZBDD99mmLO_DHH2ZWWJGWVsCyRKDV0rHkFK0wzEBgVxKkmtJspQkf5YkoYhe_TnbUfKrlQKIFXi0fRiSdrZUc8QAgKOOCCj-AGjjsloa2YTZ5yJ98__SQpOVToXwWxt_f_If8_8A_I6_3A</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Pugliese, Nicola Riccardo</creator><creator>Mengozzi, Alessandro</creator><creator>Virdis, Agostino</creator><creator>Casiglia, Edoardo</creator><creator>Tikhonoff, Valerie</creator><creator>Cicero, Arrigo F. G.</creator><creator>Ungar, Andrea</creator><creator>Rivasi, Giulia</creator><creator>Salvetti, Massimo</creator><creator>Barbagallo, Carlo M.</creator><creator>Bombelli, Michele</creator><creator>Dell’Oro, Raffaella</creator><creator>Bruno, Berardino</creator><creator>Lippa, Luciano</creator><creator>D’Elia, Lanfranco</creator><creator>Verdecchia, Paolo</creator><creator>Mallamaci, Francesca</creator><creator>Cirillo, Massimo</creator><creator>Rattazzi, Marcello</creator><creator>Cirillo, Pietro</creator><creator>Gesualdo, Loreto</creator><creator>Mazza, Alberto</creator><creator>Giannattasio, Cristina</creator><creator>Maloberti, Alessandro</creator><creator>Volpe, Massimo</creator><creator>Tocci, Giuliano</creator><creator>Georgiopoulos, Georgios</creator><creator>Iaccarino, Guido</creator><creator>Nazzaro, Pietro</creator><creator>Parati, Gianfranco</creator><creator>Palatini, Paolo</creator><creator>Galletti, Ferruccio</creator><creator>Ferri, Claudio</creator><creator>Desideri, Giovambattista</creator><creator>Viazzi, Francesca</creator><creator>Pontremoli, Roberto</creator><creator>Muiesan, Maria Lorenza</creator><creator>Grassi, Guido</creator><creator>Masi, Stefano</creator><creator>Borghi, Claudio</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5473-227X</orcidid><orcidid>https://orcid.org/0000-0003-2834-9725</orcidid><orcidid>https://orcid.org/0000-0002-4367-3884</orcidid><orcidid>https://orcid.org/0000-0002-4007-9441</orcidid><orcidid>https://orcid.org/0000-0002-0635-4921</orcidid><orcidid>https://orcid.org/0000-0002-4274-8709</orcidid><orcidid>https://orcid.org/0000-0001-7846-0101</orcidid><orcidid>https://orcid.org/0000-0003-4164-6978</orcidid><orcidid>https://orcid.org/0000-0003-4219-7043</orcidid><orcidid>https://orcid.org/0000-0001-9402-7439</orcidid></search><sort><creationdate>20210701</creationdate><title>The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk</title><author>Pugliese, Nicola Riccardo ; Mengozzi, Alessandro ; Virdis, Agostino ; Casiglia, Edoardo ; Tikhonoff, Valerie ; Cicero, Arrigo F. G. ; Ungar, Andrea ; Rivasi, Giulia ; Salvetti, Massimo ; Barbagallo, Carlo M. ; Bombelli, Michele ; Dell’Oro, Raffaella ; Bruno, Berardino ; Lippa, Luciano ; D’Elia, Lanfranco ; Verdecchia, Paolo ; Mallamaci, Francesca ; Cirillo, Massimo ; Rattazzi, Marcello ; Cirillo, Pietro ; Gesualdo, Loreto ; Mazza, Alberto ; Giannattasio, Cristina ; Maloberti, Alessandro ; Volpe, Massimo ; Tocci, Giuliano ; Georgiopoulos, Georgios ; Iaccarino, Guido ; Nazzaro, Pietro ; Parati, Gianfranco ; Palatini, Paolo ; Galletti, Ferruccio ; Ferri, Claudio ; Desideri, Giovambattista ; Viazzi, Francesca ; Pontremoli, Roberto ; Muiesan, Maria Lorenza ; Grassi, Guido ; Masi, Stefano ; Borghi, Claudio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-d96423c50ea75a25cfc847820c68d6e78b61520a4f293c0c3957db184aadbf083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular System & Cardiology</topic><topic>Cerebral infarction</topic><topic>Congestive heart failure</topic><topic>Diagnosis</topic><topic>Hypertension</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Men</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Original Paper</topic><topic>Reclassification</topic><topic>Renal function</topic><topic>Risk</topic><topic>Science & Technology</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pugliese, Nicola Riccardo</creatorcontrib><creatorcontrib>Mengozzi, Alessandro</creatorcontrib><creatorcontrib>Virdis, Agostino</creatorcontrib><creatorcontrib>Casiglia, Edoardo</creatorcontrib><creatorcontrib>Tikhonoff, Valerie</creatorcontrib><creatorcontrib>Cicero, Arrigo F. G.</creatorcontrib><creatorcontrib>Ungar, Andrea</creatorcontrib><creatorcontrib>Rivasi, Giulia</creatorcontrib><creatorcontrib>Salvetti, Massimo</creatorcontrib><creatorcontrib>Barbagallo, Carlo M.</creatorcontrib><creatorcontrib>Bombelli, Michele</creatorcontrib><creatorcontrib>Dell’Oro, Raffaella</creatorcontrib><creatorcontrib>Bruno, Berardino</creatorcontrib><creatorcontrib>Lippa, Luciano</creatorcontrib><creatorcontrib>D’Elia, Lanfranco</creatorcontrib><creatorcontrib>Verdecchia, Paolo</creatorcontrib><creatorcontrib>Mallamaci, Francesca</creatorcontrib><creatorcontrib>Cirillo, Massimo</creatorcontrib><creatorcontrib>Rattazzi, Marcello</creatorcontrib><creatorcontrib>Cirillo, Pietro</creatorcontrib><creatorcontrib>Gesualdo, Loreto</creatorcontrib><creatorcontrib>Mazza, Alberto</creatorcontrib><creatorcontrib>Giannattasio, Cristina</creatorcontrib><creatorcontrib>Maloberti, Alessandro</creatorcontrib><creatorcontrib>Volpe, Massimo</creatorcontrib><creatorcontrib>Tocci, Giuliano</creatorcontrib><creatorcontrib>Georgiopoulos, Georgios</creatorcontrib><creatorcontrib>Iaccarino, Guido</creatorcontrib><creatorcontrib>Nazzaro, Pietro</creatorcontrib><creatorcontrib>Parati, Gianfranco</creatorcontrib><creatorcontrib>Palatini, Paolo</creatorcontrib><creatorcontrib>Galletti, Ferruccio</creatorcontrib><creatorcontrib>Ferri, Claudio</creatorcontrib><creatorcontrib>Desideri, Giovambattista</creatorcontrib><creatorcontrib>Viazzi, Francesca</creatorcontrib><creatorcontrib>Pontremoli, Roberto</creatorcontrib><creatorcontrib>Muiesan, Maria Lorenza</creatorcontrib><creatorcontrib>Grassi, Guido</creatorcontrib><creatorcontrib>Masi, Stefano</creatorcontrib><creatorcontrib>Borghi, Claudio</creatorcontrib><creatorcontrib>Working Grp Uri</creatorcontrib><creatorcontrib>Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension</creatorcontrib><creatorcontrib>The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pugliese, Nicola Riccardo</au><au>Mengozzi, Alessandro</au><au>Virdis, Agostino</au><au>Casiglia, Edoardo</au><au>Tikhonoff, Valerie</au><au>Cicero, Arrigo F. G.</au><au>Ungar, Andrea</au><au>Rivasi, Giulia</au><au>Salvetti, Massimo</au><au>Barbagallo, Carlo M.</au><au>Bombelli, Michele</au><au>Dell’Oro, Raffaella</au><au>Bruno, Berardino</au><au>Lippa, Luciano</au><au>D’Elia, Lanfranco</au><au>Verdecchia, Paolo</au><au>Mallamaci, Francesca</au><au>Cirillo, Massimo</au><au>Rattazzi, Marcello</au><au>Cirillo, Pietro</au><au>Gesualdo, Loreto</au><au>Mazza, Alberto</au><au>Giannattasio, Cristina</au><au>Maloberti, Alessandro</au><au>Volpe, Massimo</au><au>Tocci, Giuliano</au><au>Georgiopoulos, Georgios</au><au>Iaccarino, Guido</au><au>Nazzaro, Pietro</au><au>Parati, Gianfranco</au><au>Palatini, Paolo</au><au>Galletti, Ferruccio</au><au>Ferri, Claudio</au><au>Desideri, Giovambattista</au><au>Viazzi, Francesca</au><au>Pontremoli, Roberto</au><au>Muiesan, Maria Lorenza</au><au>Grassi, Guido</au><au>Masi, Stefano</au><au>Borghi, Claudio</au><aucorp>Working Grp Uri</aucorp><aucorp>Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension</aucorp><aucorp>The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk</atitle><jtitle>Clinical research in cardiology</jtitle><stitle>Clin Res Cardiol</stitle><stitle>CLIN RES CARDIOL</stitle><addtitle>Clin Res Cardiol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>110</volume><issue>7</issue><spage>1073</spage><epage>1082</epage><pages>1073-1082</pages><issn>1861-0684</issn><eissn>1861-0692</eissn><abstract>Introduction
Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis.
Aim
We assessed the prognostic role of SUA in patients with and without MS.
Methods
We used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure.
Results
A total of 9589 subjects (median age 58.5 years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median follow-up of 142 months, we observed 558 events. Using a previously validated cardiovascular SUA cut-off to predict CVM (> 5.1 mg/dL in women and 5.6 mg/dL in men), elevated SUA levels were significantly associated to a worse outcome in patients with and without MS (all
p
< 0.0001) and provided a significant net reclassification improvement of 7.1% over the diagnosis of MS for CVM (
p
= 0.004). Cox regression analyses identified an independent association between SUA and CVM (Hazard Ratio: 1.79 [95% CI, 1.15–2.79];
p
< 0.0001) after the adjustment for MS, its single components and renal function. Three specific combinations of the MS components were associated with higher CVM when increasing SUA levels were reported, and systemic hypertension was the only individual component ever-present (all
p
< 0.0001).
Conclusion
Increasing SUA levels are associated with a higher CVM risk irrespective of the presence of MS: a cardiovascular SUA threshold may improve risk stratification.
Graphic abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33604722</pmid><doi>10.1007/s00392-021-01815-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5473-227X</orcidid><orcidid>https://orcid.org/0000-0003-2834-9725</orcidid><orcidid>https://orcid.org/0000-0002-4367-3884</orcidid><orcidid>https://orcid.org/0000-0002-4007-9441</orcidid><orcidid>https://orcid.org/0000-0002-0635-4921</orcidid><orcidid>https://orcid.org/0000-0002-4274-8709</orcidid><orcidid>https://orcid.org/0000-0001-7846-0101</orcidid><orcidid>https://orcid.org/0000-0003-4164-6978</orcidid><orcidid>https://orcid.org/0000-0003-4219-7043</orcidid><orcidid>https://orcid.org/0000-0001-9402-7439</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1861-0684 |
| ispartof | Clinical research in cardiology, 2021-07, Vol.110 (7), p.1073-1082 |
| issn | 1861-0684 1861-0692 |
| language | eng |
| recordid | cdi_webofscience_primary_000619380100001CitationCount |
| source | Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; SpringerLink Journals - AutoHoldings |
| subjects | Cardiac & Cardiovascular Systems Cardiology Cardiovascular diseases Cardiovascular System & Cardiology Cerebral infarction Congestive heart failure Diagnosis Hypertension Life Sciences & Biomedicine Medicine Medicine & Public Health Men Metabolic disorders Metabolic syndrome Mortality Myocardial infarction Original Paper Reclassification Renal function Risk Science & Technology Uric acid |
| title | The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T01%3A44%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20importance%20of%20including%20uric%20acid%20in%20the%20definition%20of%20metabolic%20syndrome%20when%20assessing%20the%20mortality%20risk&rft.jtitle=Clinical%20research%20in%20cardiology&rft.au=Pugliese,%20Nicola%20Riccardo&rft.aucorp=Working%20Grp%20Uri&rft.date=2021-07-01&rft.volume=110&rft.issue=7&rft.spage=1073&rft.epage=1082&rft.pages=1073-1082&rft.issn=1861-0684&rft.eissn=1861-0692&rft_id=info:doi/10.1007/s00392-021-01815-0&rft_dat=%3Cproquest_webof%3E2545795738%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2545795738&rft_id=info:pmid/33604722&rfr_iscdi=true |