Controlling antimicrobial activity and drug loading capacity of chitosan-based layer-by-layer films
We report on layer-by-layer (LbL) films of chitosans (CHI) and hyaluronic acid (HA) whose properties could be controlled by employing chitosans with different degrees of deacetylation (DD¯ ≈ 85%; 65%; 40%) and high average molecular weight (ca. 106 g/mol). In spite of their high molecular weight, th...
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| Veröffentlicht in: | International journal of biological macromolecules 2021-03, Vol.172, p.154-161 |
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| creator | Rocha Neto, J.B.M. Lima, G.G. Fiamingo, A. Germiniani, L.G.L. Taketa, T.B. Bataglioli, R.A. da Silveira, G.A.T. da Silva, J.V.L. Campana-Filho, S.P. Oliveira, O.N. Beppu, M.M. |
| description | We report on layer-by-layer (LbL) films of chitosans (CHI) and hyaluronic acid (HA) whose properties could be controlled by employing chitosans with different degrees of deacetylation (DD¯ ≈ 85%; 65%; 40%) and high average molecular weight (ca. 106 g/mol). In spite of their high molecular weight, these chitosans are soluble within a wide pH range, including physiological pH. HA/CHI LbL films produced from polymer solutions at pH 4.5 were thinner, smoother, more hydrophilic than those prepared at pH 7.2. This is attributed to the more extended conformation adopted by chitosan due to its very high charge density at low pH, favoring a compact chain packing during the film formation and resulting in lower film thickness and roughness. The smoother HA/CHI LbL films obtained at pH 4.5 were effective against Escherichia coli, while the thicker, rougher LbL films fabricated at pH 7.2 could be used in the controlled released of Rose Bengal dye. In summary, the tuning of only two parameters, i.e. solution pH and DD¯ of chitosans, provides access to a library of HA/CHI LbL films for tailored, diversified applications.
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| doi_str_mv | 10.1016/j.ijbiomac.2020.12.218 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2020.12.218</identifier><identifier>PMID: 33428951</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antimicrobial activity ; Biochemistry & Molecular Biology ; Chemistry ; Chemistry, Applied ; Chitosan ; Chitosan - chemistry ; Drug delivery ; Escherichia coli - drug effects ; Hyaluronic Acid - chemistry ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Life Sciences & Biomedicine ; Physical Sciences ; Polymer Science ; Polymers - chemistry ; Science & Technology</subject><ispartof>International journal of biological macromolecules, 2021-03, Vol.172, p.154-161</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>21</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000619184100016</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c434t-894c82a249917e08b326273c01a930828ece6077f3c2fa2fb5caf0b923a4cfc63</citedby><cites>FETCH-LOGICAL-c434t-894c82a249917e08b326273c01a930828ece6077f3c2fa2fb5caf0b923a4cfc63</cites><orcidid>0000-0002-5131-3184 ; 0000-0002-3629-6419 ; 0000-0003-4861-1006 ; 0000-0003-4987-1168 ; 0000-0002-0980-0085</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2020.12.218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33428951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocha Neto, J.B.M.</creatorcontrib><creatorcontrib>Lima, G.G.</creatorcontrib><creatorcontrib>Fiamingo, A.</creatorcontrib><creatorcontrib>Germiniani, L.G.L.</creatorcontrib><creatorcontrib>Taketa, T.B.</creatorcontrib><creatorcontrib>Bataglioli, R.A.</creatorcontrib><creatorcontrib>da Silveira, G.A.T.</creatorcontrib><creatorcontrib>da Silva, J.V.L.</creatorcontrib><creatorcontrib>Campana-Filho, S.P.</creatorcontrib><creatorcontrib>Oliveira, O.N.</creatorcontrib><creatorcontrib>Beppu, M.M.</creatorcontrib><title>Controlling antimicrobial activity and drug loading capacity of chitosan-based layer-by-layer films</title><title>International journal of biological macromolecules</title><addtitle>INT J BIOL MACROMOL</addtitle><addtitle>Int J Biol Macromol</addtitle><description>We report on layer-by-layer (LbL) films of chitosans (CHI) and hyaluronic acid (HA) whose properties could be controlled by employing chitosans with different degrees of deacetylation (DD¯ ≈ 85%; 65%; 40%) and high average molecular weight (ca. 106 g/mol). In spite of their high molecular weight, these chitosans are soluble within a wide pH range, including physiological pH. HA/CHI LbL films produced from polymer solutions at pH 4.5 were thinner, smoother, more hydrophilic than those prepared at pH 7.2. This is attributed to the more extended conformation adopted by chitosan due to its very high charge density at low pH, favoring a compact chain packing during the film formation and resulting in lower film thickness and roughness. The smoother HA/CHI LbL films obtained at pH 4.5 were effective against Escherichia coli, while the thicker, rougher LbL films fabricated at pH 7.2 could be used in the controlled released of Rose Bengal dye. In summary, the tuning of only two parameters, i.e. solution pH and DD¯ of chitosans, provides access to a library of HA/CHI LbL films for tailored, diversified applications.
[Display omitted]</description><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antimicrobial activity</subject><subject>Biochemistry & Molecular Biology</subject><subject>Chemistry</subject><subject>Chemistry, Applied</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Drug delivery</subject><subject>Escherichia coli - drug effects</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Life Sciences & Biomedicine</subject><subject>Physical Sciences</subject><subject>Polymer Science</subject><subject>Polymers - chemistry</subject><subject>Science & Technology</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi1E1S5tX6HKHWXx2NnEuYEiCkiVuMDZGk_s4lUSr2xv0b49Dtv2CieP_vk_S_Mxdgd8CxzaD_ut3xsfZqSt4KKEYitAvWEbUF1fc87lW7bh0ECtQPIr9i6lfUnbHahLdiVlI1S_gw2jISw5hmnyy2OFS_azpxiMx6lCyv7J51OJx2qMx8dqCjiuPcID0roJrqJfPoeES20w2bGa8GRjbU7136FyfprTDbtwOCV7-_xes5_3n38MX-uH71--DZ8eampkk2vVN6QEiqbvobNcGSla0UnigL3kSihLtuVd5yQJh8KZHaHjphcSG3LUymvWnv8tF6QUrdOH6GeMJw1cr9b0Xr9Y06s1DUIXawW8O4OHo5nt-Iq9aCoFdS78tia4RN4uZF9rq1foQTVQJmgHnzH7sAzhuOSCvv9_tLQ_ntu2eHryNupnYvTRUtZj8P865g9DIqOw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Rocha Neto, J.B.M.</creator><creator>Lima, G.G.</creator><creator>Fiamingo, A.</creator><creator>Germiniani, L.G.L.</creator><creator>Taketa, T.B.</creator><creator>Bataglioli, R.A.</creator><creator>da Silveira, G.A.T.</creator><creator>da Silva, J.V.L.</creator><creator>Campana-Filho, S.P.</creator><creator>Oliveira, O.N.</creator><creator>Beppu, M.M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5131-3184</orcidid><orcidid>https://orcid.org/0000-0002-3629-6419</orcidid><orcidid>https://orcid.org/0000-0003-4861-1006</orcidid><orcidid>https://orcid.org/0000-0003-4987-1168</orcidid><orcidid>https://orcid.org/0000-0002-0980-0085</orcidid></search><sort><creationdate>20210301</creationdate><title>Controlling antimicrobial activity and drug loading capacity of chitosan-based layer-by-layer films</title><author>Rocha Neto, J.B.M. ; Lima, G.G. ; Fiamingo, A. ; Germiniani, L.G.L. ; Taketa, T.B. ; Bataglioli, R.A. ; da Silveira, G.A.T. ; da Silva, J.V.L. ; Campana-Filho, S.P. ; Oliveira, O.N. ; Beppu, M.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-894c82a249917e08b326273c01a930828ece6077f3c2fa2fb5caf0b923a4cfc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antimicrobial activity</topic><topic>Biochemistry & Molecular Biology</topic><topic>Chemistry</topic><topic>Chemistry, Applied</topic><topic>Chitosan</topic><topic>Chitosan - chemistry</topic><topic>Drug delivery</topic><topic>Escherichia coli - drug effects</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Life Sciences & Biomedicine</topic><topic>Physical Sciences</topic><topic>Polymer Science</topic><topic>Polymers - chemistry</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocha Neto, J.B.M.</creatorcontrib><creatorcontrib>Lima, G.G.</creatorcontrib><creatorcontrib>Fiamingo, A.</creatorcontrib><creatorcontrib>Germiniani, L.G.L.</creatorcontrib><creatorcontrib>Taketa, T.B.</creatorcontrib><creatorcontrib>Bataglioli, R.A.</creatorcontrib><creatorcontrib>da Silveira, G.A.T.</creatorcontrib><creatorcontrib>da Silva, J.V.L.</creatorcontrib><creatorcontrib>Campana-Filho, S.P.</creatorcontrib><creatorcontrib>Oliveira, O.N.</creatorcontrib><creatorcontrib>Beppu, M.M.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocha Neto, J.B.M.</au><au>Lima, G.G.</au><au>Fiamingo, A.</au><au>Germiniani, L.G.L.</au><au>Taketa, T.B.</au><au>Bataglioli, R.A.</au><au>da Silveira, G.A.T.</au><au>da Silva, J.V.L.</au><au>Campana-Filho, S.P.</au><au>Oliveira, O.N.</au><au>Beppu, M.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlling antimicrobial activity and drug loading capacity of chitosan-based layer-by-layer films</atitle><jtitle>International journal of biological macromolecules</jtitle><stitle>INT J BIOL MACROMOL</stitle><addtitle>Int J Biol Macromol</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>172</volume><spage>154</spage><epage>161</epage><pages>154-161</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>We report on layer-by-layer (LbL) films of chitosans (CHI) and hyaluronic acid (HA) whose properties could be controlled by employing chitosans with different degrees of deacetylation (DD¯ ≈ 85%; 65%; 40%) and high average molecular weight (ca. 106 g/mol). In spite of their high molecular weight, these chitosans are soluble within a wide pH range, including physiological pH. HA/CHI LbL films produced from polymer solutions at pH 4.5 were thinner, smoother, more hydrophilic than those prepared at pH 7.2. This is attributed to the more extended conformation adopted by chitosan due to its very high charge density at low pH, favoring a compact chain packing during the film formation and resulting in lower film thickness and roughness. The smoother HA/CHI LbL films obtained at pH 4.5 were effective against Escherichia coli, while the thicker, rougher LbL films fabricated at pH 7.2 could be used in the controlled released of Rose Bengal dye. In summary, the tuning of only two parameters, i.e. solution pH and DD¯ of chitosans, provides access to a library of HA/CHI LbL films for tailored, diversified applications.
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| subjects | Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antimicrobial activity Biochemistry & Molecular Biology Chemistry Chemistry, Applied Chitosan Chitosan - chemistry Drug delivery Escherichia coli - drug effects Hyaluronic Acid - chemistry Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Life Sciences & Biomedicine Physical Sciences Polymer Science Polymers - chemistry Science & Technology |
| title | Controlling antimicrobial activity and drug loading capacity of chitosan-based layer-by-layer films |
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