Structurally modified glycyrrhetinic acid derivatives as anti-inflammatory agents

[Display omitted] •34 glycyrrhetinic acid derivatives were obtained by four structural modification methods.•The anti-inflammatory activity of compound 5b was significantly higher than glycyrrhetinic acid.•MAPK and NF-κB signaling pathways were involved in the anti-inflammatory process of compound 5...

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Veröffentlicht in:	Bioorganic chemistry 2021-02, Vol.107, p.104598-104598, Article 104598
Hauptverfasser:	Bian, Ming, Zhen, Dong, Shen, Qing-Kun, Du, Huan-Huan, Ma, Qian-Qian, Quan, Zhe-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory Biochemistry & Molecular Biology Chemistry Chemistry, Organic Glycyrrhetinic acid Life Sciences & Biomedicine Physical Sciences Science & Technology Structural modification Synthesis
Online-Zugang:	Volltext
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