H2FPEF Score Reflects the Left Atrial Strain and Predicts Prognosis in Patients With Heart Failure With Preserved Ejection Fraction
The H2FPEF score is a validated algorithm for the diagnosis of heart failure with preserved ejection fraction (HFpEF). We investigated the associations of the H2FPEF score with echocardiographic parameters and prognosis in patients with HFpEF admitted for acute heart failure. In total, 4312 patients...
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| Veröffentlicht in: | Journal of cardiac failure 2021-02, Vol.27 (2), p.198-207 |
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| container_title | Journal of cardiac failure |
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| creator | Hwang, In-Chang Cho, Goo-Yeong Choi, Hong-Mi Yoon, Yeonyee E. Park, Jin Joo Park, Jun-Bean Park, Jae-Hyeong Lee, Seung-Pyo Kim, Hyung-Kwan Kim, Yong-Jin |
| description | The H2FPEF score is a validated algorithm for the diagnosis of heart failure with preserved ejection fraction (HFpEF). We investigated the associations of the H2FPEF score with echocardiographic parameters and prognosis in patients with HFpEF admitted for acute heart failure.
In total, 4312 patients at 3 tertiary centers were identified. Among 1335 patients with HFpEF, the H2FPEF score was available in 1105 patients (39% male) with a median age of 77 years (interquartile range 69–82). The median H2FPEF score was 4 (interquartile range 3–6). Patients with higher H2FPEF scores had worse left atrial (LA) size, peak atrial longitudinal strain of the left atrium, mitral E/e’ ratio, and peak tricuspid regurgitation velocity. Peak atrial longitudinal strain of the left atrium demonstrated a significant association with the H2FPEF score, in patients without atrial fibrillation and those without atrial fibrillation. After adjustment for clinical factors and echocardiographic parameters, patients with higher H2FPEF scores had a higher risk of mortality and hospitalization for heart failure, regardless of the presence of atrial fibrillation.
The H2FPEF score reflects left atrial function in patients with HFpEF admitted for acute heart failure. This association supports the clinical usefulness of the H2FPEF score as an indicator of diastolic dysfunction, a diagnostic algorithm for HFpEF, and a prognostic factor in patients with HFpEF. |
| doi_str_mv | 10.1016/j.cardfail.2020.09.474 |
| format | Article |
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In total, 4312 patients at 3 tertiary centers were identified. Among 1335 patients with HFpEF, the H2FPEF score was available in 1105 patients (39% male) with a median age of 77 years (interquartile range 69–82). The median H2FPEF score was 4 (interquartile range 3–6). Patients with higher H2FPEF scores had worse left atrial (LA) size, peak atrial longitudinal strain of the left atrium, mitral E/e’ ratio, and peak tricuspid regurgitation velocity. Peak atrial longitudinal strain of the left atrium demonstrated a significant association with the H2FPEF score, in patients without atrial fibrillation and those without atrial fibrillation. After adjustment for clinical factors and echocardiographic parameters, patients with higher H2FPEF scores had a higher risk of mortality and hospitalization for heart failure, regardless of the presence of atrial fibrillation.
The H2FPEF score reflects left atrial function in patients with HFpEF admitted for acute heart failure. This association supports the clinical usefulness of the H2FPEF score as an indicator of diastolic dysfunction, a diagnostic algorithm for HFpEF, and a prognostic factor in patients with HFpEF.</description><identifier>ISSN: 1071-9164</identifier><identifier>EISSN: 1532-8414</identifier><identifier>DOI: 10.1016/j.cardfail.2020.09.474</identifier><identifier>PMID: 33035685</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>H2FPEF score ; Heart failure ; heart failure with preserved ejection fraction ; left atrial strain ; strain</subject><ispartof>Journal of cardiac failure, 2021-02, Vol.27 (2), p.198-207</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-712263f18f388fa70bb03f84090fd15b0812bc40a66ac41a2c0e930e2f6bc4133</citedby><cites>FETCH-LOGICAL-c368t-712263f18f388fa70bb03f84090fd15b0812bc40a66ac41a2c0e930e2f6bc4133</cites><orcidid>0000-0001-7035-286X ; 0000-0002-5502-3977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cardfail.2020.09.474$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33035685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, In-Chang</creatorcontrib><creatorcontrib>Cho, Goo-Yeong</creatorcontrib><creatorcontrib>Choi, Hong-Mi</creatorcontrib><creatorcontrib>Yoon, Yeonyee E.</creatorcontrib><creatorcontrib>Park, Jin Joo</creatorcontrib><creatorcontrib>Park, Jun-Bean</creatorcontrib><creatorcontrib>Park, Jae-Hyeong</creatorcontrib><creatorcontrib>Lee, Seung-Pyo</creatorcontrib><creatorcontrib>Kim, Hyung-Kwan</creatorcontrib><creatorcontrib>Kim, Yong-Jin</creatorcontrib><title>H2FPEF Score Reflects the Left Atrial Strain and Predicts Prognosis in Patients With Heart Failure With Preserved Ejection Fraction</title><title>Journal of cardiac failure</title><addtitle>J Card Fail</addtitle><description>The H2FPEF score is a validated algorithm for the diagnosis of heart failure with preserved ejection fraction (HFpEF). We investigated the associations of the H2FPEF score with echocardiographic parameters and prognosis in patients with HFpEF admitted for acute heart failure.
In total, 4312 patients at 3 tertiary centers were identified. Among 1335 patients with HFpEF, the H2FPEF score was available in 1105 patients (39% male) with a median age of 77 years (interquartile range 69–82). The median H2FPEF score was 4 (interquartile range 3–6). Patients with higher H2FPEF scores had worse left atrial (LA) size, peak atrial longitudinal strain of the left atrium, mitral E/e’ ratio, and peak tricuspid regurgitation velocity. Peak atrial longitudinal strain of the left atrium demonstrated a significant association with the H2FPEF score, in patients without atrial fibrillation and those without atrial fibrillation. After adjustment for clinical factors and echocardiographic parameters, patients with higher H2FPEF scores had a higher risk of mortality and hospitalization for heart failure, regardless of the presence of atrial fibrillation.
The H2FPEF score reflects left atrial function in patients with HFpEF admitted for acute heart failure. This association supports the clinical usefulness of the H2FPEF score as an indicator of diastolic dysfunction, a diagnostic algorithm for HFpEF, and a prognostic factor in patients with HFpEF.</description><subject>H2FPEF score</subject><subject>Heart failure</subject><subject>heart failure with preserved ejection fraction</subject><subject>left atrial strain</subject><subject>strain</subject><issn>1071-9164</issn><issn>1532-8414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFUU1P3DAQtSqqQmn_AvKRS8L4I05yA6FNF2mlrkqrHi3HGRevsgnY3pU488frZaHXnjwavzdv5j1CLhiUDJi62pTWhMEZP5YcOJTQlrKWH8gZqwQvGsnkSa6hZkXLlDwln2PcAEAjof5EToUAUammOiMvS96tFx29t3NA-gPdiDZFmh6QrtAlepOCNyO9T8H4iZppoOuAgz9g1mH-M83RR5p_1iZ5nHL3t08PdIkmJNrl7XZ56msr0yKGPQ50sckSfp5oF8xr8YV8dGaM-PXtPSe_usXP22Wx-v7t7vZmVVihmlTUjHMlHGucaBpnauh7EC5f1IIbWNVDw3hvJRiljJXMcAvYCkDuVG4zIc7J5XHuY5ifdhiT3vpocRzNhPMuai5l21aVAp6h6gi1YY4xoNOPwW9NeNYM9CEAvdHvAehDABpanQPIxIs3jV2_xeEf7d3xDLg-AjBfuvcYdLTZOZtNDdkXPcz-fxp_AS4fmjQ</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Hwang, In-Chang</creator><creator>Cho, Goo-Yeong</creator><creator>Choi, Hong-Mi</creator><creator>Yoon, Yeonyee E.</creator><creator>Park, Jin Joo</creator><creator>Park, Jun-Bean</creator><creator>Park, Jae-Hyeong</creator><creator>Lee, Seung-Pyo</creator><creator>Kim, Hyung-Kwan</creator><creator>Kim, Yong-Jin</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7035-286X</orcidid><orcidid>https://orcid.org/0000-0002-5502-3977</orcidid></search><sort><creationdate>202102</creationdate><title>H2FPEF Score Reflects the Left Atrial Strain and Predicts Prognosis in Patients With Heart Failure With Preserved Ejection Fraction</title><author>Hwang, In-Chang ; Cho, Goo-Yeong ; Choi, Hong-Mi ; Yoon, Yeonyee E. ; Park, Jin Joo ; Park, Jun-Bean ; Park, Jae-Hyeong ; Lee, Seung-Pyo ; Kim, Hyung-Kwan ; Kim, Yong-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-712263f18f388fa70bb03f84090fd15b0812bc40a66ac41a2c0e930e2f6bc4133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>H2FPEF score</topic><topic>Heart failure</topic><topic>heart failure with preserved ejection fraction</topic><topic>left atrial strain</topic><topic>strain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, In-Chang</creatorcontrib><creatorcontrib>Cho, Goo-Yeong</creatorcontrib><creatorcontrib>Choi, Hong-Mi</creatorcontrib><creatorcontrib>Yoon, Yeonyee E.</creatorcontrib><creatorcontrib>Park, Jin Joo</creatorcontrib><creatorcontrib>Park, Jun-Bean</creatorcontrib><creatorcontrib>Park, Jae-Hyeong</creatorcontrib><creatorcontrib>Lee, Seung-Pyo</creatorcontrib><creatorcontrib>Kim, Hyung-Kwan</creatorcontrib><creatorcontrib>Kim, Yong-Jin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiac failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, In-Chang</au><au>Cho, Goo-Yeong</au><au>Choi, Hong-Mi</au><au>Yoon, Yeonyee E.</au><au>Park, Jin Joo</au><au>Park, Jun-Bean</au><au>Park, Jae-Hyeong</au><au>Lee, Seung-Pyo</au><au>Kim, Hyung-Kwan</au><au>Kim, Yong-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>H2FPEF Score Reflects the Left Atrial Strain and Predicts Prognosis in Patients With Heart Failure With Preserved Ejection Fraction</atitle><jtitle>Journal of cardiac failure</jtitle><addtitle>J Card Fail</addtitle><date>2021-02</date><risdate>2021</risdate><volume>27</volume><issue>2</issue><spage>198</spage><epage>207</epage><pages>198-207</pages><issn>1071-9164</issn><eissn>1532-8414</eissn><abstract>The H2FPEF score is a validated algorithm for the diagnosis of heart failure with preserved ejection fraction (HFpEF). We investigated the associations of the H2FPEF score with echocardiographic parameters and prognosis in patients with HFpEF admitted for acute heart failure.
In total, 4312 patients at 3 tertiary centers were identified. Among 1335 patients with HFpEF, the H2FPEF score was available in 1105 patients (39% male) with a median age of 77 years (interquartile range 69–82). The median H2FPEF score was 4 (interquartile range 3–6). Patients with higher H2FPEF scores had worse left atrial (LA) size, peak atrial longitudinal strain of the left atrium, mitral E/e’ ratio, and peak tricuspid regurgitation velocity. Peak atrial longitudinal strain of the left atrium demonstrated a significant association with the H2FPEF score, in patients without atrial fibrillation and those without atrial fibrillation. After adjustment for clinical factors and echocardiographic parameters, patients with higher H2FPEF scores had a higher risk of mortality and hospitalization for heart failure, regardless of the presence of atrial fibrillation.
The H2FPEF score reflects left atrial function in patients with HFpEF admitted for acute heart failure. This association supports the clinical usefulness of the H2FPEF score as an indicator of diastolic dysfunction, a diagnostic algorithm for HFpEF, and a prognostic factor in patients with HFpEF.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33035685</pmid><doi>10.1016/j.cardfail.2020.09.474</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7035-286X</orcidid><orcidid>https://orcid.org/0000-0002-5502-3977</orcidid></addata></record> |
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| subjects | H2FPEF score Heart failure heart failure with preserved ejection fraction left atrial strain strain |
| title | H2FPEF Score Reflects the Left Atrial Strain and Predicts Prognosis in Patients With Heart Failure With Preserved Ejection Fraction |
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