Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration

We previously reported a model of progressive retinal degeneration resulting from the knockout of the retina-specific riboflavin binding protein, retbindin (Rtbdn −/−). We also demonstrated a reduction in neural retinal flavins as a result of the elimination of RTBDN. Given the role of flavins in me...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-02, Vol.118 (6), p.1-9
Hauptverfasser:	Sinha, Tirthankar, Du, Jianhai, Makia, Mustafa S., Hurley, James B., Naash, Muna I., Al-Ubaidi, Muayyad R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences
Online-Zugang:	Volltext
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