Prenatal exposure to barium and the occurrence of neural tube defects in offspring
Neural tube defects (NTDs) have a complex etiology. Few studies have assessed alkaline earth metals exposures and occurrence of NTDs. We examined the association between prenatal exposure to magnesium (Mg), calcium (Ca), strontium (Sr) and barium (Ba) and risk for NTDs in a case-control study, and a...
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| creator | Wang, Chengrong Pi, Xin Chen, Yongyan Wang, Di Yin, Shengju Jin, Lei Li, Zhiwen Ren, Aiguo Wang, Linlin Yin, Chenghong |
| description | Neural tube defects (NTDs) have a complex etiology. Few studies have assessed alkaline earth metals exposures and occurrence of NTDs. We examined the association between prenatal exposure to magnesium (Mg), calcium (Ca), strontium (Sr) and barium (Ba) and risk for NTDs in a case-control study, and assessed the teratogenic effects of Ba on mice. Placentas were collected from 408 women with NTD-affected pregnancies and 593 women who delivered healthy infants, and concentrations of these metals were determined as prenatal exposure markers. The single effect of individual exposure and joint effect of coexposure to these metals were evaluated with logistic regression and Bayesian kernel machine regression (BKMR), respectively. Barium chloride (BaCl2) was intragastrically administered to pregnant ICR mice and fetal mice were examined for NTDs. Median concentrations of Mg and Ba were higher in NTD cases than in controls (Pall |
| doi_str_mv | 10.1016/j.scitotenv.2020.144245 |
| format | Article |
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[Display omitted]
•Concentrations of Mg, Ca, Sr and Ba in placental tissue were used as prenatal exposure markers.•Higher levels of Ba were associated with elevated NTD risk in both logistic regression and BKMR.•Higher levels of Ca were associated with reduced NTD risk when the other metals were considered.•NTD risk increased with levels of all metals when they were treated as a coexposure mixture.•Prenatal administration of Ba by gavage may induce fetal NTDs in ICR mice.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2020.144245</identifier><identifier>PMID: 33385660</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Alkaline earth metal ; Animals ; Barium ; Barium - toxicity ; Bayes Theorem ; Bayesian kernel machine regression ; Case-Control Studies ; Environmental Sciences ; Environmental Sciences & Ecology ; Female ; ICR mice ; Life Sciences & Biomedicine ; Mice ; Mice, Inbred ICR ; Mixture effect ; Neural tube defects ; Neural Tube Defects - chemically induced ; Neural Tube Defects - epidemiology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Science & Technology</subject><ispartof>The Science of the total environment, 2021-04, Vol.764, p.144245, Article 144245</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>16</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000614249600124</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c338t-5259b5f15a1e71486f9018f86ba7888030411a4c403a2774f5eaf77da71f9fc63</citedby><cites>FETCH-LOGICAL-c338t-5259b5f15a1e71486f9018f86ba7888030411a4c403a2774f5eaf77da71f9fc63</cites><orcidid>0000-0001-9115-5638 ; 0000-0002-5709-6643</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2020.144245$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33385660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chengrong</creatorcontrib><creatorcontrib>Pi, Xin</creatorcontrib><creatorcontrib>Chen, Yongyan</creatorcontrib><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Yin, Shengju</creatorcontrib><creatorcontrib>Jin, Lei</creatorcontrib><creatorcontrib>Li, Zhiwen</creatorcontrib><creatorcontrib>Ren, Aiguo</creatorcontrib><creatorcontrib>Wang, Linlin</creatorcontrib><creatorcontrib>Yin, Chenghong</creatorcontrib><title>Prenatal exposure to barium and the occurrence of neural tube defects in offspring</title><title>The Science of the total environment</title><addtitle>SCI TOTAL ENVIRON</addtitle><addtitle>Sci Total Environ</addtitle><description>Neural tube defects (NTDs) have a complex etiology. Few studies have assessed alkaline earth metals exposures and occurrence of NTDs. We examined the association between prenatal exposure to magnesium (Mg), calcium (Ca), strontium (Sr) and barium (Ba) and risk for NTDs in a case-control study, and assessed the teratogenic effects of Ba on mice. Placentas were collected from 408 women with NTD-affected pregnancies and 593 women who delivered healthy infants, and concentrations of these metals were determined as prenatal exposure markers. The single effect of individual exposure and joint effect of coexposure to these metals were evaluated with logistic regression and Bayesian kernel machine regression (BKMR), respectively. Barium chloride (BaCl2) was intragastrically administered to pregnant ICR mice and fetal mice were examined for NTDs. Median concentrations of Mg and Ba were higher in NTD cases than in controls (Pall < 0.001). In logistic regression, higher levels of Ba were associated with 1.6-fold increased risk for NTDs (95% confidence interval: 1.06–2.43). In BKMR, the joint effect of the four-metal mixture on NTD risk increased steadily with the levels of the mixture. A change in Ba concentration from the 25th to 75th percentile displayed a risk effect when the other three metals were fixed at the 25th, 50th or 75th percentile, while such a change in Ca concentration showed a protective effect when the other metals were held at the 25th or 50th percentile. No interactions among metals were found. In the mouse experiment, dams treated with 200 mg/kg BaCl2 showed 16.8% of NTDs in fetal mice, compared to 2.6% in the untreated control group (P < 0.01). Taken together, higher mixture levels of the four alkaline earth metals were associated with increased risk for NTDs, with Ba being the major contributor for the joint effect. Intragastric administration of Ba can induce NTDs in mice.
[Display omitted]
•Concentrations of Mg, Ca, Sr and Ba in placental tissue were used as prenatal exposure markers.•Higher levels of Ba were associated with elevated NTD risk in both logistic regression and BKMR.•Higher levels of Ca were associated with reduced NTD risk when the other metals were considered.•NTD risk increased with levels of all metals when they were treated as a coexposure mixture.•Prenatal administration of Ba by gavage may induce fetal NTDs in ICR mice.</description><subject>Alkaline earth metal</subject><subject>Animals</subject><subject>Barium</subject><subject>Barium - toxicity</subject><subject>Bayes Theorem</subject><subject>Bayesian kernel machine regression</subject><subject>Case-Control Studies</subject><subject>Environmental Sciences</subject><subject>Environmental Sciences & Ecology</subject><subject>Female</subject><subject>ICR mice</subject><subject>Life Sciences & Biomedicine</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mixture effect</subject><subject>Neural tube defects</subject><subject>Neural Tube Defects - chemically induced</subject><subject>Neural Tube Defects - epidemiology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Science & Technology</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkMFuGyEQhlHVqHGdvkLKvVoHdllgj5HVJpUiJYqSM2LZocGyFwvYNHn7jrWury0X0PD9M5qPkK-crTjj8mqzyi6UWGB8XdWsxqoQtWg_kAXXqqs4q-VHsmBM6KqTnTonn3PeMDxK80_kvGka3UrJFuTxIcFoi91SeNvHPCWgJdLepjDtqB0HWl6ARuemhJzDp6cjTAn5MvVAB_DgSqZhxB-f9ymMvy7ImbfbDF-O95I8__j-tL6t7u5vfq6v7yqH00vV1m3Xt563loPiQkvfMa69lr1VWmvWMMG5FU6wxtZKCd-C9UoNVnHfeSebJVFzX5dizgm8wfE7m94NZ-ZgyWzMyZI5WDKzJUxezsn91O9gOOX-akFAz8Bv6KPHJofdTxhqlBwbdZIxXot1KLaEOK7jNBaMfvv_KNLXMw0o6jVAMsfEEBKKNUMM_9zmD1_GnhM</recordid><startdate>20210410</startdate><enddate>20210410</enddate><creator>Wang, Chengrong</creator><creator>Pi, Xin</creator><creator>Chen, Yongyan</creator><creator>Wang, Di</creator><creator>Yin, Shengju</creator><creator>Jin, Lei</creator><creator>Li, Zhiwen</creator><creator>Ren, Aiguo</creator><creator>Wang, Linlin</creator><creator>Yin, Chenghong</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-9115-5638</orcidid><orcidid>https://orcid.org/0000-0002-5709-6643</orcidid></search><sort><creationdate>20210410</creationdate><title>Prenatal exposure to barium and the occurrence of neural tube defects in offspring</title><author>Wang, Chengrong ; Pi, Xin ; Chen, Yongyan ; Wang, Di ; Yin, Shengju ; Jin, Lei ; Li, Zhiwen ; Ren, Aiguo ; Wang, Linlin ; Yin, Chenghong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-5259b5f15a1e71486f9018f86ba7888030411a4c403a2774f5eaf77da71f9fc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alkaline earth metal</topic><topic>Animals</topic><topic>Barium</topic><topic>Barium - toxicity</topic><topic>Bayes Theorem</topic><topic>Bayesian kernel machine regression</topic><topic>Case-Control Studies</topic><topic>Environmental Sciences</topic><topic>Environmental Sciences & Ecology</topic><topic>Female</topic><topic>ICR mice</topic><topic>Life Sciences & Biomedicine</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mixture effect</topic><topic>Neural tube defects</topic><topic>Neural Tube Defects - chemically induced</topic><topic>Neural Tube Defects - epidemiology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Chengrong</creatorcontrib><creatorcontrib>Pi, Xin</creatorcontrib><creatorcontrib>Chen, Yongyan</creatorcontrib><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Yin, Shengju</creatorcontrib><creatorcontrib>Jin, Lei</creatorcontrib><creatorcontrib>Li, Zhiwen</creatorcontrib><creatorcontrib>Ren, Aiguo</creatorcontrib><creatorcontrib>Wang, Linlin</creatorcontrib><creatorcontrib>Yin, Chenghong</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Chengrong</au><au>Pi, Xin</au><au>Chen, Yongyan</au><au>Wang, Di</au><au>Yin, Shengju</au><au>Jin, Lei</au><au>Li, Zhiwen</au><au>Ren, Aiguo</au><au>Wang, Linlin</au><au>Yin, Chenghong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal exposure to barium and the occurrence of neural tube defects in offspring</atitle><jtitle>The Science of the total environment</jtitle><stitle>SCI TOTAL ENVIRON</stitle><addtitle>Sci Total Environ</addtitle><date>2021-04-10</date><risdate>2021</risdate><volume>764</volume><spage>144245</spage><pages>144245-</pages><artnum>144245</artnum><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>Neural tube defects (NTDs) have a complex etiology. Few studies have assessed alkaline earth metals exposures and occurrence of NTDs. We examined the association between prenatal exposure to magnesium (Mg), calcium (Ca), strontium (Sr) and barium (Ba) and risk for NTDs in a case-control study, and assessed the teratogenic effects of Ba on mice. Placentas were collected from 408 women with NTD-affected pregnancies and 593 women who delivered healthy infants, and concentrations of these metals were determined as prenatal exposure markers. The single effect of individual exposure and joint effect of coexposure to these metals were evaluated with logistic regression and Bayesian kernel machine regression (BKMR), respectively. Barium chloride (BaCl2) was intragastrically administered to pregnant ICR mice and fetal mice were examined for NTDs. Median concentrations of Mg and Ba were higher in NTD cases than in controls (Pall < 0.001). In logistic regression, higher levels of Ba were associated with 1.6-fold increased risk for NTDs (95% confidence interval: 1.06–2.43). In BKMR, the joint effect of the four-metal mixture on NTD risk increased steadily with the levels of the mixture. A change in Ba concentration from the 25th to 75th percentile displayed a risk effect when the other three metals were fixed at the 25th, 50th or 75th percentile, while such a change in Ca concentration showed a protective effect when the other metals were held at the 25th or 50th percentile. No interactions among metals were found. In the mouse experiment, dams treated with 200 mg/kg BaCl2 showed 16.8% of NTDs in fetal mice, compared to 2.6% in the untreated control group (P < 0.01). Taken together, higher mixture levels of the four alkaline earth metals were associated with increased risk for NTDs, with Ba being the major contributor for the joint effect. Intragastric administration of Ba can induce NTDs in mice.
[Display omitted]
•Concentrations of Mg, Ca, Sr and Ba in placental tissue were used as prenatal exposure markers.•Higher levels of Ba were associated with elevated NTD risk in both logistic regression and BKMR.•Higher levels of Ca were associated with reduced NTD risk when the other metals were considered.•NTD risk increased with levels of all metals when they were treated as a coexposure mixture.•Prenatal administration of Ba by gavage may induce fetal NTDs in ICR mice.</abstract><cop>AMSTERDAM</cop><pub>Elsevier B.V</pub><pmid>33385660</pmid><doi>10.1016/j.scitotenv.2020.144245</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9115-5638</orcidid><orcidid>https://orcid.org/0000-0002-5709-6643</orcidid></addata></record> |
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| subjects | Alkaline earth metal Animals Barium Barium - toxicity Bayes Theorem Bayesian kernel machine regression Case-Control Studies Environmental Sciences Environmental Sciences & Ecology Female ICR mice Life Sciences & Biomedicine Mice Mice, Inbred ICR Mixture effect Neural tube defects Neural Tube Defects - chemically induced Neural Tube Defects - epidemiology Pregnancy Prenatal Exposure Delayed Effects Science & Technology |
| title | Prenatal exposure to barium and the occurrence of neural tube defects in offspring |
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