Vascular endothelial S1pr1 ameliorates adverse cardiac remodelling via stimulating reparative macrophage proliferation after myocardial infarction

Abstract Aims Endothelial cell (EC) homoeostasis plays an important role in normal physiological cardiac functions, and its dysfunction significantly influences pathological cardiac remodelling after myocardial infarction (MI). It has been shown that the sphingosine 1-phosphate receptor 1 (S1pr1) w...

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Veröffentlicht in:	Cardiovascular research 2021-01, Vol.117 (2), p.585-599
Hauptverfasser:	Kuang, Yashu, Li, Xiaolin, Liu, Xiuxiang, Wei, Lu, Chen, Xiaoli, Liu, Jie, Zhuang, Tao, Pi, Jingjiang, Wang, Yanfang, Zhu, Chenying, Gong, Xin, Hu, Hao, Yu, Zuoren, Li, Jiming, Yu, Ping, Fan, Huimin, Zhang, Yuzhen, Liu, Zhongmin, Zhang, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - metabolism Calcium-Binding Proteins - metabolism Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Cell Communication Cell Proliferation Cells, Cultured Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Extracellular Signal-Regulated MAP Kinases Female Humans Life Sciences & Biomedicine Lysophospholipids - metabolism Macrophage Colony-Stimulating Factor - metabolism Macrophages - metabolism Macrophages - pathology Mice Mice, Knockout Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Parabiosis Receptors, G-Protein-Coupled - metabolism Regeneration Science & Technology Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine-1-Phosphate Receptors - genetics Sphingosine-1-Phosphate Receptors - metabolism Ventricular Function, Left Ventricular Remodeling
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