Association of pericardial adipose tissue with left ventricular structure and function: a region-specific effect?
Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general...
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| Veröffentlicht in: | Cardiovascular Diabetology 2021-01, Vol.20 (1), p.26-26, Article 26 |
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| creator | Kim, Jin-Seok Kim, Seon Won Lee, Jong Seok Lee, Seung Ku Abbott, Robert Lee, Ki Yeol Lim, Hong Euy Sung, Ki-Chul Cho, Goo-Yeong Koh, Kwang Kon Kim, Sun H. Shin, Chol Kim, Seong Hwan |
| description | Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography with tissue Doppler imaging (TDI) and computed tomography measurement for PAT. Results Study participants with more PAT were more likely to be men and had higher cardiometabolic indices, including blood pressure, glucose, and cholesterol levels (all P < 0.001). Greater pericardial fat levels across quartiles of PAT were associated with increased LV mass index and left atrial volume index (all P < 0.001) and decreased systolic (P = 0.015) and early diastolic (P < 0.001) TDI velocities, except for LV ejection fraction. These associations remained after a multivariable-adjusted model for traditional CV risk factors and persisted even after additional adjustment for general adiposity measures, such as waist circumference and body mass index. PAT was also the only obesity index independently associated with systolic TDI velocity (P < 0.001). Conclusions PAT was associated with subclinical LV structural and functional deterioration, and these associations were independent of and stronger than with general and abdominal obesity measures. |
| doi_str_mv | 10.1186/s12933-021-01219-4 |
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This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography with tissue Doppler imaging (TDI) and computed tomography measurement for PAT. Results Study participants with more PAT were more likely to be men and had higher cardiometabolic indices, including blood pressure, glucose, and cholesterol levels (all P < 0.001). Greater pericardial fat levels across quartiles of PAT were associated with increased LV mass index and left atrial volume index (all P < 0.001) and decreased systolic (P = 0.015) and early diastolic (P < 0.001) TDI velocities, except for LV ejection fraction. These associations remained after a multivariable-adjusted model for traditional CV risk factors and persisted even after additional adjustment for general adiposity measures, such as waist circumference and body mass index. PAT was also the only obesity index independently associated with systolic TDI velocity (P < 0.001). Conclusions PAT was associated with subclinical LV structural and functional deterioration, and these associations were independent of and stronger than with general and abdominal obesity measures.</description><identifier>ISSN: 1475-2840</identifier><identifier>EISSN: 1475-2840</identifier><identifier>DOI: 10.1186/s12933-021-01219-4</identifier><identifier>PMID: 33494780</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject><![CDATA[Adipose tissue ; Adipose tissues ; Blood pressure ; Body fat ; Body mass index ; Cardiac & Cardiovascular Systems ; Cardiac arrhythmia ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular System & Cardiology ; Cholesterol ; Computed tomography ; Creatinine ; CT imaging ; Diabetes ; Doppler effect ; Echocardiography ; Ejection fraction ; Endocrinology & Metabolism ; Epidemiology ; Fasting ; Genomes ; Genomics ; Glucose ; Heart ; Hypertension ; Left ventricular function ; Left ventricular hypertrophy ; Life Sciences & Biomedicine ; Obesity ; Original Investigation ; Pericardium ; Population ; Pulmonary arteries ; Regression analysis ; Risk factors ; Science & Technology ; Software ; Structure-function relationships ; Tissue doppler echocardiography ; Type 2 diabetes ; Variables ; Variance analysis ; Veins & arteries ; Ventricle]]></subject><ispartof>Cardiovascular Diabetology, 2021-01, Vol.20 (1), p.26-26, Article 26</ispartof><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>19</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000613098400002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c612t-5345af92e501b187251c9885e1b54f1758e6a50a1a3e62174fc60ddaf71b204c3</citedby><cites>FETCH-LOGICAL-c612t-5345af92e501b187251c9885e1b54f1758e6a50a1a3e62174fc60ddaf71b204c3</cites><orcidid>0000-0001-8102-8352 ; 0000-0001-7735-1763 ; 0000-0002-8019-2713 ; 0000-0002-1854-9312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836147/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836147/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33494780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jin-Seok</creatorcontrib><creatorcontrib>Kim, Seon Won</creatorcontrib><creatorcontrib>Lee, Jong Seok</creatorcontrib><creatorcontrib>Lee, Seung Ku</creatorcontrib><creatorcontrib>Abbott, Robert</creatorcontrib><creatorcontrib>Lee, Ki Yeol</creatorcontrib><creatorcontrib>Lim, Hong Euy</creatorcontrib><creatorcontrib>Sung, Ki-Chul</creatorcontrib><creatorcontrib>Cho, Goo-Yeong</creatorcontrib><creatorcontrib>Koh, Kwang Kon</creatorcontrib><creatorcontrib>Kim, Sun H.</creatorcontrib><creatorcontrib>Shin, Chol</creatorcontrib><creatorcontrib>Kim, Seong Hwan</creatorcontrib><title>Association of pericardial adipose tissue with left ventricular structure and function: a region-specific effect?</title><title>Cardiovascular Diabetology</title><addtitle>CARDIOVASC DIABETOL</addtitle><addtitle>Cardiovasc Diabetol</addtitle><description>Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography with tissue Doppler imaging (TDI) and computed tomography measurement for PAT. Results Study participants with more PAT were more likely to be men and had higher cardiometabolic indices, including blood pressure, glucose, and cholesterol levels (all P < 0.001). Greater pericardial fat levels across quartiles of PAT were associated with increased LV mass index and left atrial volume index (all P < 0.001) and decreased systolic (P = 0.015) and early diastolic (P < 0.001) TDI velocities, except for LV ejection fraction. These associations remained after a multivariable-adjusted model for traditional CV risk factors and persisted even after additional adjustment for general adiposity measures, such as waist circumference and body mass index. PAT was also the only obesity index independently associated with systolic TDI velocity (P < 0.001). Conclusions PAT was associated with subclinical LV structural and functional deterioration, and these associations were independent of and stronger than with general and abdominal obesity measures.</description><subject>Adipose tissue</subject><subject>Adipose tissues</subject><subject>Blood pressure</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular System & Cardiology</subject><subject>Cholesterol</subject><subject>Computed tomography</subject><subject>Creatinine</subject><subject>CT imaging</subject><subject>Diabetes</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Ejection fraction</subject><subject>Endocrinology & Metabolism</subject><subject>Epidemiology</subject><subject>Fasting</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Glucose</subject><subject>Heart</subject><subject>Hypertension</subject><subject>Left ventricular function</subject><subject>Left ventricular hypertrophy</subject><subject>Life Sciences & Biomedicine</subject><subject>Obesity</subject><subject>Original Investigation</subject><subject>Pericardium</subject><subject>Population</subject><subject>Pulmonary arteries</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>Software</subject><subject>Structure-function relationships</subject><subject>Tissue doppler echocardiography</subject><subject>Type 2 diabetes</subject><subject>Variables</subject><subject>Variance analysis</subject><subject>Veins & arteries</subject><subject>Ventricle</subject><issn>1475-2840</issn><issn>1475-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktv1DAUhSMEoqXwB1ggS2yQUIqvH4nDAjQa8ahUiQ2sLce5nrrKxFPbacW_xzMpo5YVzsJXzjmfc29OVb0Geg6gmg8JWMd5TRnUFBh0tXhSnYJoZc2UoE8f1CfVi5SuKYVWNfC8OuFcdKJV9LS6WaUUrDfZh4kER3YYvTVx8GYkZvC7kJBkn9KM5M7nKzKiy-QWp1xk82giSTnONs8RiZkG4ubJ7lEfiSERN6Wq0w6td94SdA5t_vyyeubMmPDV_X5W_fr65ef6e33549vFenVZ2wZYriUX0riOoaTQg2qZBNspJRF6KRy0UmFjJDVgODYMWuFsQ4fBuBZ6RoXlZ9XFwh2Cuda76Lcm_tbBeH04CHGjTczejqgFSmMGg7blZVjSKmgaU3hc9W1XiIX1aWHt5n6Lg933b8ZH0MdvJn-lN-FWt4o35S8UwLt7QAw3M6astz5ZHEczYZiTZkIBMCnlXvr2H-l1mONURlVUHe2Aq7YpqvNFtTGlAT-5UO615Rlw622Y0PlyvmokFVJAx4qBLQYbQ0oR3fHrgep9nPQSJ13ipA9x0qKY3jzs-2j5m58iUIvgDvvgkvU4WTzKKKUNcNqVoZbF1j4fcrYO85SL9f3_W_kfJajnjA</recordid><startdate>20210125</startdate><enddate>20210125</enddate><creator>Kim, Jin-Seok</creator><creator>Kim, Seon Won</creator><creator>Lee, Jong Seok</creator><creator>Lee, Seung Ku</creator><creator>Abbott, Robert</creator><creator>Lee, Ki Yeol</creator><creator>Lim, Hong Euy</creator><creator>Sung, Ki-Chul</creator><creator>Cho, Goo-Yeong</creator><creator>Koh, Kwang Kon</creator><creator>Kim, Sun H.</creator><creator>Shin, Chol</creator><creator>Kim, Seong Hwan</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed 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of pericardial adipose tissue with left ventricular structure and function: a region-specific effect?</title><author>Kim, Jin-Seok ; Kim, Seon Won ; Lee, Jong Seok ; Lee, Seung Ku ; Abbott, Robert ; Lee, Ki Yeol ; Lim, Hong Euy ; Sung, Ki-Chul ; Cho, Goo-Yeong ; Koh, Kwang Kon ; Kim, Sun H. ; Shin, Chol ; Kim, Seong Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c612t-5345af92e501b187251c9885e1b54f1758e6a50a1a3e62174fc60ddaf71b204c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissue</topic><topic>Adipose tissues</topic><topic>Blood pressure</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular System & Cardiology</topic><topic>Cholesterol</topic><topic>Computed tomography</topic><topic>Creatinine</topic><topic>CT imaging</topic><topic>Diabetes</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Ejection fraction</topic><topic>Endocrinology & Metabolism</topic><topic>Epidemiology</topic><topic>Fasting</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Glucose</topic><topic>Heart</topic><topic>Hypertension</topic><topic>Left ventricular function</topic><topic>Left ventricular hypertrophy</topic><topic>Life Sciences & Biomedicine</topic><topic>Obesity</topic><topic>Original Investigation</topic><topic>Pericardium</topic><topic>Population</topic><topic>Pulmonary arteries</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>Software</topic><topic>Structure-function relationships</topic><topic>Tissue doppler echocardiography</topic><topic>Type 2 diabetes</topic><topic>Variables</topic><topic>Variance analysis</topic><topic>Veins & arteries</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jin-Seok</creatorcontrib><creatorcontrib>Kim, Seon Won</creatorcontrib><creatorcontrib>Lee, Jong Seok</creatorcontrib><creatorcontrib>Lee, Seung Ku</creatorcontrib><creatorcontrib>Abbott, Robert</creatorcontrib><creatorcontrib>Lee, Ki Yeol</creatorcontrib><creatorcontrib>Lim, Hong Euy</creatorcontrib><creatorcontrib>Sung, Ki-Chul</creatorcontrib><creatorcontrib>Cho, Goo-Yeong</creatorcontrib><creatorcontrib>Koh, Kwang Kon</creatorcontrib><creatorcontrib>Kim, Sun H.</creatorcontrib><creatorcontrib>Shin, Chol</creatorcontrib><creatorcontrib>Kim, Seong Hwan</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic 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Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cardiovascular Diabetology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jin-Seok</au><au>Kim, Seon Won</au><au>Lee, Jong Seok</au><au>Lee, Seung Ku</au><au>Abbott, Robert</au><au>Lee, Ki Yeol</au><au>Lim, Hong Euy</au><au>Sung, Ki-Chul</au><au>Cho, Goo-Yeong</au><au>Koh, Kwang Kon</au><au>Kim, Sun H.</au><au>Shin, Chol</au><au>Kim, Seong Hwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of pericardial adipose tissue with left ventricular structure and function: a region-specific effect?</atitle><jtitle>Cardiovascular Diabetology</jtitle><stitle>CARDIOVASC DIABETOL</stitle><addtitle>Cardiovasc Diabetol</addtitle><date>2021-01-25</date><risdate>2021</risdate><volume>20</volume><issue>1</issue><spage>26</spage><epage>26</epage><pages>26-26</pages><artnum>26</artnum><issn>1475-2840</issn><eissn>1475-2840</eissn><abstract>Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography with tissue Doppler imaging (TDI) and computed tomography measurement for PAT. Results Study participants with more PAT were more likely to be men and had higher cardiometabolic indices, including blood pressure, glucose, and cholesterol levels (all P < 0.001). Greater pericardial fat levels across quartiles of PAT were associated with increased LV mass index and left atrial volume index (all P < 0.001) and decreased systolic (P = 0.015) and early diastolic (P < 0.001) TDI velocities, except for LV ejection fraction. These associations remained after a multivariable-adjusted model for traditional CV risk factors and persisted even after additional adjustment for general adiposity measures, such as waist circumference and body mass index. PAT was also the only obesity index independently associated with systolic TDI velocity (P < 0.001). Conclusions PAT was associated with subclinical LV structural and functional deterioration, and these associations were independent of and stronger than with general and abdominal obesity measures.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>33494780</pmid><doi>10.1186/s12933-021-01219-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8102-8352</orcidid><orcidid>https://orcid.org/0000-0001-7735-1763</orcidid><orcidid>https://orcid.org/0000-0002-8019-2713</orcidid><orcidid>https://orcid.org/0000-0002-1854-9312</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose tissue Adipose tissues Blood pressure Body fat Body mass index Cardiac & Cardiovascular Systems Cardiac arrhythmia Cardiovascular disease Cardiovascular diseases Cardiovascular System & Cardiology Cholesterol Computed tomography Creatinine CT imaging Diabetes Doppler effect Echocardiography Ejection fraction Endocrinology & Metabolism Epidemiology Fasting Genomes Genomics Glucose Heart Hypertension Left ventricular function Left ventricular hypertrophy Life Sciences & Biomedicine Obesity Original Investigation Pericardium Population Pulmonary arteries Regression analysis Risk factors Science & Technology Software Structure-function relationships Tissue doppler echocardiography Type 2 diabetes Variables Variance analysis Veins & arteries Ventricle |
| title | Association of pericardial adipose tissue with left ventricular structure and function: a region-specific effect? |
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