Effect of residual insomnia and use of hypnotics on relapse of depression: a retrospective cohort study using a health insurance claims database
•Residual insomnia was associated with the highest risk of depression recurrence.•This retrospective cohort study used the largest health claims database in Japan.•Ending antidepressant treatment above the recommended maximum dose was also a risk.•Prior use of neurological/psychotropic medication an...
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| Veröffentlicht in: | Journal of affective disorders 2021-02, Vol.281, p.539-546 |
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| creator | Inada, Ken Enomoto, Minori Yamato, Kentaro Marumoto, Tatsuro Takeshima, Masahiro Mishima, Kazuo |
| description | •Residual insomnia was associated with the highest risk of depression recurrence.•This retrospective cohort study used the largest health claims database in Japan.•Ending antidepressant treatment above the recommended maximum dose was also a risk.•Prior use of neurological/psychotropic medication and anxiolytics was also a risk.
Residual insomnia is associated with a risk of depression recurrence.
In this retrospective, longitudinal cohort study, the recurrence pattern of depression in patients with or without residual insomnia was assessed using a health insurance claims database. Patients who were diagnosed with major depressive disorder and prescribed antidepressants, between January 2006 and June 2017 in Japan, were enrolled in the study. Residual insomnia was defined by a prescription of hypnotics, and recurrence of depression by prescription of antidepressants. Main outcomes included time to recurrence and the 1-year recurrence rate. Factors associated with recurrence of depression were assessed by multivariate analyses. The effect of residual insomnia on the frequency of recurrence was assessed by Chi-square test.
Of the 30,381 patients analyzed, there were 4,166 and 26,215 patients with or without residual insomnia, respectively. Time to recurrence in patients with residual insomnia was significantly shorter compared with those without residual insomnia (p |
| doi_str_mv | 10.1016/j.jad.2020.12.040 |
| format | Article |
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Residual insomnia is associated with a risk of depression recurrence.
In this retrospective, longitudinal cohort study, the recurrence pattern of depression in patients with or without residual insomnia was assessed using a health insurance claims database. Patients who were diagnosed with major depressive disorder and prescribed antidepressants, between January 2006 and June 2017 in Japan, were enrolled in the study. Residual insomnia was defined by a prescription of hypnotics, and recurrence of depression by prescription of antidepressants. Main outcomes included time to recurrence and the 1-year recurrence rate. Factors associated with recurrence of depression were assessed by multivariate analyses. The effect of residual insomnia on the frequency of recurrence was assessed by Chi-square test.
Of the 30,381 patients analyzed, there were 4,166 and 26,215 patients with or without residual insomnia, respectively. Time to recurrence in patients with residual insomnia was significantly shorter compared with those without residual insomnia (p <0.001), with a 1-year recurrence rate (95% CI) of 43.4% (41.9–45.0) and 7.4% (7.1–7.7), respectively. The frequency of recurrence was significantly higher in patients with residual insomnia than in those without (p <0.0001). A higher risk of depression recurrence (odds ratio 9.98, 95% CI 9.22–10.81) was found for residual insomnia compared with other significant factors.
The diagnosis stated in the receipt data may not accurately reflect the patient's condition, and medication adherence was unknown but assumed.
Residual insomnia is a significant risk factor for depression recurrence in Japanese patients.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2020.12.040</identifier><identifier>PMID: 33401142</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Claims database ; Clinical Neurology ; Cohort Studies ; Depression - drug therapy ; Depression - epidemiology ; Depression recurrence ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - epidemiology ; Humans ; Hypnotics ; Hypnotics and Sedatives - therapeutic use ; Insurance, Health ; Japan - epidemiology ; Japanese patients ; Life Sciences & Biomedicine ; Longitudinal Studies ; Major depressive disorder ; Neurosciences & Neurology ; Psychiatry ; Recurrence ; Residual insomnia ; Retrospective Studies ; Science & Technology ; Sleep Initiation and Maintenance Disorders - drug therapy ; Sleep Initiation and Maintenance Disorders - epidemiology</subject><ispartof>Journal of affective disorders, 2021-02, Vol.281, p.539-546</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000612525800020</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c462t-96f7f727f5791fce5115e549df6e46a8a5d3c07aa144a4d30655b52b2cff76cb3</citedby><cites>FETCH-LOGICAL-c462t-96f7f727f5791fce5115e549df6e46a8a5d3c07aa144a4d30655b52b2cff76cb3</cites><orcidid>0000-0002-5027-6289 ; 0000-0003-0614-7524</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2020.12.040$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33401142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inada, Ken</creatorcontrib><creatorcontrib>Enomoto, Minori</creatorcontrib><creatorcontrib>Yamato, Kentaro</creatorcontrib><creatorcontrib>Marumoto, Tatsuro</creatorcontrib><creatorcontrib>Takeshima, Masahiro</creatorcontrib><creatorcontrib>Mishima, Kazuo</creatorcontrib><title>Effect of residual insomnia and use of hypnotics on relapse of depression: a retrospective cohort study using a health insurance claims database</title><title>Journal of affective disorders</title><addtitle>J AFFECT DISORDERS</addtitle><addtitle>J Affect Disord</addtitle><description>•Residual insomnia was associated with the highest risk of depression recurrence.•This retrospective cohort study used the largest health claims database in Japan.•Ending antidepressant treatment above the recommended maximum dose was also a risk.•Prior use of neurological/psychotropic medication and anxiolytics was also a risk.
Residual insomnia is associated with a risk of depression recurrence.
In this retrospective, longitudinal cohort study, the recurrence pattern of depression in patients with or without residual insomnia was assessed using a health insurance claims database. Patients who were diagnosed with major depressive disorder and prescribed antidepressants, between January 2006 and June 2017 in Japan, were enrolled in the study. Residual insomnia was defined by a prescription of hypnotics, and recurrence of depression by prescription of antidepressants. Main outcomes included time to recurrence and the 1-year recurrence rate. Factors associated with recurrence of depression were assessed by multivariate analyses. The effect of residual insomnia on the frequency of recurrence was assessed by Chi-square test.
Of the 30,381 patients analyzed, there were 4,166 and 26,215 patients with or without residual insomnia, respectively. Time to recurrence in patients with residual insomnia was significantly shorter compared with those without residual insomnia (p <0.001), with a 1-year recurrence rate (95% CI) of 43.4% (41.9–45.0) and 7.4% (7.1–7.7), respectively. The frequency of recurrence was significantly higher in patients with residual insomnia than in those without (p <0.0001). A higher risk of depression recurrence (odds ratio 9.98, 95% CI 9.22–10.81) was found for residual insomnia compared with other significant factors.
The diagnosis stated in the receipt data may not accurately reflect the patient's condition, and medication adherence was unknown but assumed.
Residual insomnia is a significant risk factor for depression recurrence in Japanese patients.</description><subject>Claims database</subject><subject>Clinical Neurology</subject><subject>Cohort Studies</subject><subject>Depression - drug therapy</subject><subject>Depression - epidemiology</subject><subject>Depression recurrence</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Humans</subject><subject>Hypnotics</subject><subject>Hypnotics and Sedatives - therapeutic use</subject><subject>Insurance, Health</subject><subject>Japan - epidemiology</subject><subject>Japanese patients</subject><subject>Life Sciences & Biomedicine</subject><subject>Longitudinal Studies</subject><subject>Major depressive disorder</subject><subject>Neurosciences & Neurology</subject><subject>Psychiatry</subject><subject>Recurrence</subject><subject>Residual insomnia</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Sleep Initiation and Maintenance Disorders - drug therapy</subject><subject>Sleep Initiation and Maintenance Disorders - epidemiology</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhSMEYjoDD8AGeYmEUmwnjltYoWoGkEZiA2vrxj_UVWIH2xnUt-CRuVHKLBEr_33nWPecqnrF6JZR1r07bU9gtpxyPPMtbemTasOEbGoumHxabZARNW24vKqucz5RSru9pM-rq6ZpKWMt31S_b52zupDoSLLZmxkG4kOOY_BAIBgyZ7s8Hs9TiMXrTGJAcoBpvTd2Ql32MbwngA8lxTyhoX-wRMdjTIXkMpsz-vjwA5GjhaEclz_mBEEjNYAfMzFQoIdsX1TPHAzZvrysN9X3u9tvh8_1_ddPXw4f72vddrzU-85JJ7l0Qu6Z01YwJqxo98Z1tu1gB8I0mkoA1rbQmoZ2QvSC91w7JzvdNzfVm9V3SvHnbHNRo8_aDgMEG-eseCuFQJmUiLIV1ThcTtapKfkR0lkxqpYi1ElhEWopQjGusAjUvL7Yz_1ozaPib_II7Fbgl-2jy9pbDOMRW6piXHCxwx2nB1-gYMaHOIeC0rf_L0X6w0pbTPPB26QuCuMTFqVM9P-Y4w_T77v-</recordid><startdate>20210215</startdate><enddate>20210215</enddate><creator>Inada, Ken</creator><creator>Enomoto, Minori</creator><creator>Yamato, Kentaro</creator><creator>Marumoto, Tatsuro</creator><creator>Takeshima, Masahiro</creator><creator>Mishima, Kazuo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5027-6289</orcidid><orcidid>https://orcid.org/0000-0003-0614-7524</orcidid></search><sort><creationdate>20210215</creationdate><title>Effect of residual insomnia and use of hypnotics on relapse of depression: a retrospective cohort study using a health insurance claims database</title><author>Inada, Ken ; Enomoto, Minori ; Yamato, Kentaro ; Marumoto, Tatsuro ; Takeshima, Masahiro ; Mishima, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-96f7f727f5791fce5115e549df6e46a8a5d3c07aa144a4d30655b52b2cff76cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Claims database</topic><topic>Clinical Neurology</topic><topic>Cohort Studies</topic><topic>Depression - drug therapy</topic><topic>Depression - epidemiology</topic><topic>Depression recurrence</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Humans</topic><topic>Hypnotics</topic><topic>Hypnotics and Sedatives - therapeutic use</topic><topic>Insurance, Health</topic><topic>Japan - epidemiology</topic><topic>Japanese patients</topic><topic>Life Sciences & Biomedicine</topic><topic>Longitudinal Studies</topic><topic>Major depressive disorder</topic><topic>Neurosciences & Neurology</topic><topic>Psychiatry</topic><topic>Recurrence</topic><topic>Residual insomnia</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Sleep Initiation and Maintenance Disorders - drug therapy</topic><topic>Sleep Initiation and Maintenance Disorders - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inada, Ken</creatorcontrib><creatorcontrib>Enomoto, Minori</creatorcontrib><creatorcontrib>Yamato, Kentaro</creatorcontrib><creatorcontrib>Marumoto, Tatsuro</creatorcontrib><creatorcontrib>Takeshima, Masahiro</creatorcontrib><creatorcontrib>Mishima, Kazuo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Knowledge</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Web of Science - Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inada, Ken</au><au>Enomoto, Minori</au><au>Yamato, Kentaro</au><au>Marumoto, Tatsuro</au><au>Takeshima, Masahiro</au><au>Mishima, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of residual insomnia and use of hypnotics on relapse of depression: a retrospective cohort study using a health insurance claims database</atitle><jtitle>Journal of affective disorders</jtitle><stitle>J AFFECT DISORDERS</stitle><addtitle>J Affect Disord</addtitle><date>2021-02-15</date><risdate>2021</risdate><volume>281</volume><spage>539</spage><epage>546</epage><pages>539-546</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•Residual insomnia was associated with the highest risk of depression recurrence.•This retrospective cohort study used the largest health claims database in Japan.•Ending antidepressant treatment above the recommended maximum dose was also a risk.•Prior use of neurological/psychotropic medication and anxiolytics was also a risk.
Residual insomnia is associated with a risk of depression recurrence.
In this retrospective, longitudinal cohort study, the recurrence pattern of depression in patients with or without residual insomnia was assessed using a health insurance claims database. Patients who were diagnosed with major depressive disorder and prescribed antidepressants, between January 2006 and June 2017 in Japan, were enrolled in the study. Residual insomnia was defined by a prescription of hypnotics, and recurrence of depression by prescription of antidepressants. Main outcomes included time to recurrence and the 1-year recurrence rate. Factors associated with recurrence of depression were assessed by multivariate analyses. The effect of residual insomnia on the frequency of recurrence was assessed by Chi-square test.
Of the 30,381 patients analyzed, there were 4,166 and 26,215 patients with or without residual insomnia, respectively. Time to recurrence in patients with residual insomnia was significantly shorter compared with those without residual insomnia (p <0.001), with a 1-year recurrence rate (95% CI) of 43.4% (41.9–45.0) and 7.4% (7.1–7.7), respectively. The frequency of recurrence was significantly higher in patients with residual insomnia than in those without (p <0.0001). A higher risk of depression recurrence (odds ratio 9.98, 95% CI 9.22–10.81) was found for residual insomnia compared with other significant factors.
The diagnosis stated in the receipt data may not accurately reflect the patient's condition, and medication adherence was unknown but assumed.
Residual insomnia is a significant risk factor for depression recurrence in Japanese patients.</abstract><cop>AMSTERDAM</cop><pub>Elsevier B.V</pub><pmid>33401142</pmid><doi>10.1016/j.jad.2020.12.040</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5027-6289</orcidid><orcidid>https://orcid.org/0000-0003-0614-7524</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Claims database Clinical Neurology Cohort Studies Depression - drug therapy Depression - epidemiology Depression recurrence Depressive Disorder, Major - drug therapy Depressive Disorder, Major - epidemiology Humans Hypnotics Hypnotics and Sedatives - therapeutic use Insurance, Health Japan - epidemiology Japanese patients Life Sciences & Biomedicine Longitudinal Studies Major depressive disorder Neurosciences & Neurology Psychiatry Recurrence Residual insomnia Retrospective Studies Science & Technology Sleep Initiation and Maintenance Disorders - drug therapy Sleep Initiation and Maintenance Disorders - epidemiology |
| title | Effect of residual insomnia and use of hypnotics on relapse of depression: a retrospective cohort study using a health insurance claims database |
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